公开(公告)号：US09999600B2

公开(公告)日：2018-06-19

申请号：US15362476

申请日：2016-11-28

申请人： N-Fold LLC

发明人： Howard B. Sosin ,  Michael J. Caplan

IPC分类号： A61K9/51 ,  A61K39/35 ,  A61K9/50 ,  A61K39/02 ,  A61K39/145 ,  A61K39/39 ,  C12N7/00 ,  A61K39/108 ,  A61K39/00

CPC分类号： A61K9/5153 ,  A61K9/5031 ,  A61K9/5176 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/145 ,  A61K39/35 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55594 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/394 ,  Y02A50/401 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/414 ,  Y02A50/416

摘要： The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.

公开(公告)号：US20210077617A1

公开(公告)日：2021-03-18

申请号：US16960869

申请日：2019-01-08

申请人： N-Fold LLC

发明人： Howard B. Sosin ,  Michael J. Caplan

IPC分类号： A61K39/35 ,  A61K39/39

摘要： The disclosure relates to compositions, methods of use and making, and kits for immunomodulation. In some embodiments, the present invention also provides compositions including at least one antigen substantially co-localized with at least one adjuvant agent in a format selected from patch, capsule, tablet, gel, matrix, paste, reservoir, adhesive, liquid, suspension, lyophilized solid, liquid contained within one or more lumenal units, and combinations thereof, wherein one or both of the antigen and the adjuvant agent is a crude preparation, and wherein the composition is characterized in that administration to a subject in need thereof results in an immune response in the subject to the antigen.