公开(公告)号：US20210318261A1

公开(公告)日：2021-10-14

申请号：US17268715

申请日：2019-08-06

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO ,  Wei-Peng LI

IPC: G01N27/406

Abstract: A measurement device according to one embodiment of the present invention, comprises: a voltage applying part for applying a voltage between electrodes of a biosensor, the biosensor comprising a solid electrolyte and at least two electrodes, and being configured such that the solid electrolyte and the electrodes are in contact with each other; a detection part for measuring a current value flowing between the electrodes when the voltage is applied; and a computing part for providing information resulting from the microorganisms by comparing the current value with a reference value stored in advance in which a current value and at least one type of factor selected from the group consisting of the presence or absence of the biological particles, a proliferative state of the microorganisms, and the presence or absence of expression of pathogenicity of the microorganisms are defined.

公开(公告)号：US20210255142A1

公开(公告)日：2021-08-19

申请号：US17256832

申请日：2019-07-05

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO ,  Divya NARADASU

IPC: G01N27/48 ,  G01N33/487 ,  G01N27/327

Abstract: [Object] An object of the present technology to provide a diagnosing apparatus capable of providing, more accurately and simply, information for determining at least one item selected from the group consisting of a type of an illness that has developed in a subject, and a state of progress of the illness that has developed in the subject. Another object of the present technology is to provide an analysis method.
[Solving Means] There is provided a diagnosing apparatus including: a cell into which a sample solution including collected body fluid is introduced; at least two electrodes that are disposed in the cell and come into contact with the sample solution; a voltage applying unit that applies a voltage between the electrodes; a measuring unit that measures an electrochemical response when the voltage is applied; a storage unit that stores a reference; and an analysis output unit that compares a numerical value obtained from the response with the reference, and provides information for determining at least one item selected from the group consisting of a type of an illness that has developed in a subject, and a state of progress of the illness that has developed in the subject.

公开(公告)号：US20220214302A1

公开(公告)日：2022-07-07

申请号：US17600313

申请日：2020-05-12

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO

IPC: G01N27/327 ,  A61C19/04

Abstract: A detection apparatus includes: an electrode formation unit that is brought into contact with an object to form an electrode; a detection unit that constitutes an electrode pair with the electrode; a measurement unit that measures a current flowing between the electrode and the detection unit; and a determination unit that determines presence or absence of an abnormality related to bacteria attached to the object according to the current measured by the measurement unit.

公开(公告)号：US20240268942A1

公开(公告)日：2024-08-15

申请号：US18569539

申请日：2022-06-08

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO ,  Waheed MIRAN

IPC: A61C19/06 ,  A61C8/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61C19/06 ,  A61C8/0012 ,  A61N1/0548 ,  A61N1/36031 ,  A61N1/36034

Abstract: A peri-implantitis treatment device (1) according to the present invention includes: an electrode (14) for applying a negative electric potential to a metal portion (7) of a dental implant (8); a potential controller for controlling the electric potential of the electrode (14); and a mouthpiece (2) that holds the electrode (14) and the potential controller and is attached to the dental implant (8). The peri-implantitis treatment device (1) according to the present invention makes it possible to effectively inactivate even bacteria (colonies) that have formed biofilms hard to inactivate by antibiotics in deep periodontal pockets where mechanical cleaning is difficult.

公开(公告)号：US20240385140A1

公开(公告)日：2024-11-21

申请号：US18569549

申请日：2022-06-21

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO ,  Divya NARADASU

IPC: G01N27/416 ,  G01N33/569

Abstract: The in vitro diagnostic method for periodontal disease of the present invention includes bringing a sample derived from an oral cavity of a subject into contact with an electrode to perform electrochemical measurement in the presence of a glucogenic amino acid and an electron mediator under an anaerobic environment and providing information for judging that periodontal disease is progressing in the oral cavity of the subject when current generation is detected as a result of the electrochemical measurement. According to the in vitro diagnostic method for periodontal disease of the present invention, it is possible to provide information for judging the progress of periodontal disease by simple operation.

公开(公告)号：US20240279635A1

公开(公告)日：2024-08-22

申请号：US18569545

申请日：2022-06-08

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO ,  Waheed MIRAN

IPC: C12N13/00 ,  A61L2/03 ,  C12N1/20 ,  C12Q1/02

CPC classification number: C12N13/00 ,  A61L2/03 ,  C12N1/20 ,  C12Q1/02 ,  A61L2202/24

Abstract: A biofilm activity adjusting method according to the present invention, includes: bringing a medium containing 2-hydroxy-1,4-naphthoquinone and water into contact with a conductor having a bacterium-derived biofilm; and adjusting the biofilm activity by applying, to the conductor, a first electric potential of higher than a lower limit value of an electric potential window and −0.4 V or lower with respect to a silver/silver chloride electrode reference. The biofilm activity adjusting method according to the present invention makes it possible to obtain an excellent activity adjusting effect on the biofilm.

公开(公告)号：US20220154243A1

公开(公告)日：2022-05-19

申请号：US17593987

申请日：2020-03-23

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Akihiro OKAMOTO

IPC: C12Q1/04 ,  B01L3/00 ,  G16B40/20 ,  G01N27/327 ,  G01N27/49 ,  G01N27/417

Abstract: [Object] To provide a measurement apparatus capable of easily acquiring microbiota information regarding a specimen, and also provide a measurement method and a program.
[Solving Means] A measurement apparatus includes: a voltage applying unit that applies a voltage between at least two electrodes disposed so as to come into contact with a complex in which a specimen including a microorganism and a medium including a substrate are in contact with each other; a measuring unit that measures a response when the voltage is applied; a storage unit in which a classifier is stored; and an analysis output unit that applies the substrate and the response to the classifier, and outputs microbiota information regarding the specimen, in which the classifier is a classifier which has been pre-learned by using learning data including known microbiota information regarding a learning specimen, a substrate, and a response to be obtained so as to output, when the substrate used for measurement and the obtained response are input, microbiota information regarding a specimen to be measured.