公开(公告)号：US12012432B2

公开(公告)日：2024-06-18

申请号：US16995477

申请日：2020-08-17

Applicant: National Institute of Advanced Industrial Science and Technology

Inventor： Yasuo Komatsu ,  Yu Hirano ,  Yasuhiro Mie

IPC: C07H21/04 ,  A61K31/7088 ,  A61K31/713 ,  A61K48/00 ,  C07H21/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/6832

CPC classification number: C07H21/04 ,  A61K31/7088 ,  A61K31/713 ,  A61K48/00 ,  C07H21/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/6832 ,  C12N2310/141 ,  C12N2310/321

Abstract: A nucleic acid complex includes a single-stranded nucleic acid and a cross-linked double-stranded nucleic acid including the first nucleic acid strand linked to at least one of the 5′ end and the 3′ end of the single-stranded nucleic acid and the second nucleic acid strand including a base sequence that is completely or sufficiently complementary to the first nucleic acid strand.

公开(公告)号：US20170349623A1

公开(公告)日：2017-12-07

申请号：US15532916

申请日：2015-12-08

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Yasuo Komatsu ,  Yu Hirano ,  Yasuhiro Mie

IPC: C07H21/04 ,  C12Q1/68 ,  C07H21/02 ,  C12N15/113

CPC classification number: C07H21/04 ,  A61K31/7088 ,  A61K31/713 ,  A61K48/00 ,  C07H21/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/113 ,  C12N2310/141 ,  C12N2310/321 ,  C12Q1/68 ,  C12Q1/6832

Abstract: A nucleic acid complex includes a single-stranded nucleic acid and a cross-linked double-stranded nucleic acid including the first nucleic acid strand linked to at least one of the 5′ end and the 3′ end of the single-stranded nucleic acid and the second nucleic acid strand including a base sequence that is completely or sufficiently complementary to the first nucleic acid strand.