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公开(公告)号：US11739154B2
公开(公告)日：2023-08-29
申请号：US16646823
申请日：2018-09-10
CPC分类号： C07K16/2863 , A61K47/6803 , A61K49/00 , A61P35/00 , C12N5/16 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.
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公开(公告)号：US20190352376A1
公开(公告)日：2019-11-21
申请号：US16480727
申请日：2018-01-26
发明人： Aziza Manceur , Anne Marcil , Wei Zou , Amine Kamen , Christine Gadoury
IPC分类号： C07K16/10 , G01N33/569 , A61P31/16
摘要： The present invention relates to hemagglutinin-specific antibodies, fragments thereof, and uses thereof. More specifically, these antibodies and fragments thereof are able to recognize antigen from multiple influenza strains.
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公开(公告)号：US20180186893A1
公开(公告)日：2018-07-05
申请号：US15580713
申请日：2016-06-10
IPC分类号： C07K16/40 , A61K47/68 , G01N33/573 , A61K51/10
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6871 , A61K51/1075 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/988
摘要： The present invention relates to isolated or purified antibodies or fragments thereof specific for Carbohydrate Anhydrase IX (CA-IX) and their use as therapeutic tools. Specifically, the present invention is directed to high-affinity Carbohydrate Anhydrase IX-specific antibodies and fragments thereof and their use as antibody-drug conjugates. Compositions for use in therapy as well as therapeutic methods are also described.
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公开(公告)号：US11945858B2
公开(公告)日：2024-04-02
申请号：US17056243
申请日：2019-05-17
发明人： Marzia Martina , Balu Chakravarthy , Yves Durocher , Mehdi Arbabi-Ghahroudi , Anne Marcil , Danica Stanimirovic , Traian Sulea , Maria Moreno , Umberto Banderali
CPC分类号： C07K16/18 , A61P29/00 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/92
摘要： The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.
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公开(公告)号：US11566064B2
公开(公告)日：2023-01-31
申请号：US16480727
申请日：2018-01-26
发明人： Aziza Manceur , Anne Marcil , Wei Zou , Amine Kamen , Christine Gadoury
IPC分类号： A61P31/16 , C07K16/10 , G01N33/569 , A61K39/00
摘要： The present invention relates to hemagglutinin-specific antibodies, fragments thereof, and uses thereof. More specifically, these antibodies and fragments thereof are able to recognize antigen from multiple influenza strains.
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公开(公告)号：US20200331988A9
公开(公告)日：2020-10-22
申请号：US16480727
申请日：2018-01-26
发明人： Aziza Manceur , Anne Marcil , Wei Zou , Amine Kamen , Christine Gadoury
IPC分类号： C07K16/10 , G01N33/569 , A61P31/16
摘要： The present invention relates to hemagglutinin-specific antibodies, fragments thereof, and uses thereof. More specifically, these antibodies and fragments thereof are able to recognize antigen from multiple influenza strains.
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