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公开(公告)号：US20190382765A1
公开(公告)日：2019-12-19
申请号：US16464057
申请日：2017-10-12
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115 , C12N15/10
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1). In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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2.发明申请NUCLEOTIDE DERIVATIVE OR SALT THEREOF, NUCLEOTIDE-DERIVED 5'-PHOSPHATE ESTER OR SALT THEREOF, NUCLEOTIDE-DERIVED 3'-PHOSPHORAMIDITE COMPOUND OR SALT THEREOF, AND POLYNUCLEOTIDE 审中-公开核苷衍生物或其盐，核苷衍生的5'-磷酸酯或其盐，核苷衍生的3'-磷酰胺化合物或其盐，和多核苷酸公开(公告)号：US20160311845A1
公开(公告)日：2016-10-27
申请号：US15032623
申请日：2014-09-10
发明人： Masayasu KUWAHARA
IPC分类号： C07H19/20 , C12N15/115 , C12N15/10 , C07H19/16
CPC分类号： C07H19/20 , C07H19/073 , C07H19/10 , C07H19/16 , C07H19/173 , C12N15/1048 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2320/51 , C12N2330/31
摘要： A nucleoside derivative represented by any of the following formulae (I-1) to (I-6) or a salt thereof: in the formulae (I-1) to (I-6), R1 to R5, A1 to A3, B, X, Y, and k represent the meanings as described in claim 1.
摘要翻译： 在式（I-1）至（I-6）中，R1至R5，A1至A3，B，X，Y和k表示权利要求1中所述的含义。
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公开(公告)号：US20190248826A1
公开(公告)日：2019-08-15
申请号：US16333325
申请日：2017-09-14
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , C07H19/073 , C07H21/00 , C07K16/00 , C12N15/115 , Y02P20/55
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule.The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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4.发明申请公开(公告)号：US20190241895A1
公开(公告)日：2019-08-08
申请号：US16333293
申请日：2017-04-20
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N15/09 , C12N2310/16 , C12N2310/333 , C12N2310/335 , C12N2310/336 , C12Q1/68 , G01N33/53
摘要： The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
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公开(公告)号：US20190211048A1
公开(公告)日：2019-07-11
申请号：US16333333
申请日：2017-09-14
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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