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公开(公告)号：US20190382765A1
公开(公告)日：2019-12-19
申请号：US16464057
申请日：2017-10-12
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115 , C12N15/10
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1). In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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公开(公告)号：US20190248826A1
公开(公告)日：2019-08-15
申请号：US16333325
申请日：2017-09-14
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , C07H19/073 , C07H21/00 , C07K16/00 , C12N15/115 , Y02P20/55
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule.The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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3.发明申请公开(公告)号：US20190241895A1
公开(公告)日：2019-08-08
申请号：US16333293
申请日：2017-04-20
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N15/09 , C12N2310/16 , C12N2310/333 , C12N2310/335 , C12N2310/336 , C12Q1/68 , G01N33/53
摘要： The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
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公开(公告)号：US20190211048A1
公开(公告)日：2019-07-11
申请号：US16333333
申请日：2017-09-14
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.
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公开(公告)号：US20180327746A1
公开(公告)日：2018-11-15
申请号：US15775797
申请日：2016-09-12
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Ikuo SHIRATORI , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115 , C12Q1/40 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/115 , C12N15/1048 , C12N2310/16 , C12N2310/335 , C12Q1/40 , C12Q1/68 , C12Y302/01001 , G01N33/53
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.
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公开(公告)号：US20200248181A1
公开(公告)日：2020-08-06
申请号：US15776142
申请日：2015-11-16
发明人： Tomoko SHIRATORI , Naoto KANEKO , Ikuo SHIRATORI , Katsunori HORII , Hirotaka MINAGAWA , Jou AKITOMI , Yoshihito YOSHIDA , Iwao WAGA
IPC分类号： C12N15/115 , C07K14/415 , C12Q1/6883
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of a wheat allergen. The wheat allergen-binding nucleic acid according to the present invention is characterized in that it binds to a wheat allergen with a dissociation constant of 20 nM or less, and preferably includes a polynucleotide consisting of either of base sequences of SEQ ID NOs: 1 and 2, for example.
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