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公开(公告)号：US20250066373A1
公开(公告)日：2025-02-27
申请号：US18946291
申请日：2024-11-13
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: C07D487/04 , A61P35/00 , C07D231/12
Abstract: A pharmaceutical composition is provided which includes monoterpene derivatives such as perillyl alcohol conjugated with a therapeutic agent and further includes and an aliphatic tail such as a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
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公开(公告)号：US20220133712A1
公开(公告)日：2022-05-05
申请号：US17573693
申请日：2022-01-12
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: A61K31/495 , A61K31/415 , A61K47/54 , A61K45/06 , A61N5/10 , C07D207/26 , C07D231/12 , C07D487/04 , A61K31/4188 , A61K31/045 , A61K31/4015 , C07B59/00 , C07C33/14 , A61K9/00
Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
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公开(公告)号：US20210130271A1
公开(公告)日：2021-05-06
申请号：US17123365
申请日：2020-12-16
Applicant: NEONC Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: C07C29/92 , A61K31/045 , C07C201/16 , C07C201/12 , C07C67/14 , C07C29/88 , C07C29/86 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/78
Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
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公开(公告)号：US20190241568A1
公开(公告)日：2019-08-08
申请号：US16126586
申请日：2018-09-10
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish Puppali
IPC: C07D487/04 , A61P35/00 , C07D231/12
Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
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公开(公告)号：US20230145207A1
公开(公告)日：2023-05-11
申请号：US18150933
申请日：2023-01-06
Applicant: NEONC TECHNOLOGIES, INC.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: A61K31/20 , A61K47/55 , A61K9/00 , A61K31/045 , A61K45/06
CPC classification number: A61K31/20 , A61K47/55 , A61K9/0043 , A61K31/045 , A61K45/06
Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
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Patent Agency Ranking
公开(公告)号：US20230043663A1
公开(公告)日：2023-02-09
申请号：US17943567
申请日：2022-09-13
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish Puppali
IPC: C07D487/04 , C07D231/12 , A61P35/00
Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
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公开(公告)号：US20210268108A1
公开(公告)日：2021-09-02
申请号：US17306167
申请日：2021-05-03
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: A61K45/06 , A61K31/4015 , A61K9/00 , A61K31/415 , C07D487/04 , C07D231/12 , C07D207/26 , A61K47/54 , A61K47/55
Abstract: The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.
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公开(公告)号：US20170369408A1
公开(公告)日：2017-12-28
申请号：US15482451
申请日：2017-04-07
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPALLI
IPC: C07C33/14 , C07D231/12 , A61K47/54 , C07D207/26 , C07B59/00 , A61K45/06 , A61K31/495 , A61K31/4188 , A61K31/415 , A61K31/4015 , A61K31/045 , C07D487/04 , A61N5/10 , C07C2601/16
CPC classification number: A61K31/495 , A61K9/0043 , A61K31/045 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61N5/10 , C07B59/00 , C07B2200/05 , C07C33/14 , C07C2601/16 , C07D207/26 , C07D231/12 , C07D487/04
Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
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公开(公告)号：US20210283127A1
公开(公告)日：2021-09-16
申请号：US17313258
申请日：2021-05-06
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC: A61K31/495 , A61K31/415 , A61K47/54 , A61K45/06 , A61N5/10 , C07D207/26 , C07D231/12 , C07D487/04 , A61K31/4188 , A61K31/045 , A61K31/4015 , C07B59/00 , C07C33/14 , A61K9/00
Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
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公开(公告)号：US20210244820A1
公开(公告)日：2021-08-12
申请号：US17251452
申请日：2019-06-17
Applicant: NeOnc Technologies, Inc.
Inventor： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
Abstract: The present invention provides a method for treating inflammation in a mammal. The method includes delivering to the mammal a therapeutically effective amount of a composition including a perillyl alcohol (POH) conjugated with linoleic acid.
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