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公开(公告)号：US20240239730A1
公开(公告)日：2024-07-18
申请号：US18618449
申请日：2024-03-27
发明人： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07B2200/07 , C07C2601/16
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
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公开(公告)号：US20230392107A1
公开(公告)日：2023-12-07
申请号：US17804948
申请日：2022-06-01
申请人： LanzaTech, Inc.
摘要： The disclosure is directed to a method and a system for recovering at least one organic product from fermentation broth. The disclosure relates to the use of liquid-liquid extraction and/or distillation to recover at least one organic product from a fermentation broth. In an embodiment, the recovery of the product is completed in a manner that minimizes stress on the microbial biomass, such that it remains viable, at least in part, and may be recycled and reused in the fermentation process, with minimal water extraction which results in increased efficiency in the fermentation process.
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公开(公告)号：US20230348348A1
公开(公告)日：2023-11-02
申请号：US18347432
申请日：2023-07-05
发明人： Markus NAHRWOLD
CPC分类号： C07C29/175 , C07C29/80 , C07C29/86
摘要： The present invention relates to a process for the manufacturing of 3-phenylpropan-1-ol, from nature derived starting material, wherein said nature derived starting material comprises not less than 80 wt.% of cinnamaldehyde. In another aspect, the present invention relates to the process, which further comprises the steps: a) conversion of cinnamaldehyde as starting material to 3-phenylpropan-1-ol by a catalytic hydrogenation; b) optional purification of the 3-phenylpropan-1-ol by alkaline water extraction; c) distillation of 3-phenylpropan-1-ol. In a third aspect the present invention relates to use of 3-phenylpropan-1-ol obtained by the process of the invention in perfumes and/or personal care and/or cleaning products.
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公开(公告)号：US11578024B2
公开(公告)日：2023-02-14
申请号：US17280595
申请日：2019-09-19
发明人： Yi Yuan
摘要： The invention provides a process for refining bio-based propylene glycol, wherein impurities having boiling points close to that of propylene glycol are separated. In this process, C5-C20 oleophilic alcohol compounds, C5-C20 alkanes and/or C4-C20 oleophilic ketone compounds are subjected to azeotropism as an azeotropic solvent together with the bio-based propylene glycol to obtain an azeotrope containing propylene glycol. Then the azeotropic solvent in the azeotrope is separated to obtain a crude propylene glycol which is further purified to obtain propylene glycol.
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公开(公告)号：US20220363619A1
公开(公告)日：2022-11-17
申请号：US17749293
申请日：2022-05-20
发明人： Thomas CHEN , Daniel LEVIN , Satish PUPPALI
IPC分类号： C07C29/92 , C07C67/14 , C07C201/12 , A61K31/045 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/86
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
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公开(公告)号：US11440863B2
公开(公告)日：2022-09-13
申请号：US16888920
申请日：2020-06-01
发明人： Peter Kucmierczyk , Robert Franke , Dirk Fridag , Johannes Knossalla , Marc Schäpertöns , Frederik Gluth
IPC分类号： C07C29/149 , C07C67/38 , C07C29/76 , C07C29/78 , C07C29/80 , C07C29/86 , B01J31/22 , C07C67/48 , C07C29/132 , C07C67/03
摘要： The invention provides a process for preparing an alcohol by hydrogenating an ester which is obtained by alkoxycarbonylating a C2 to C20 hydrocarbon having at least one multiple bond, preferably having at least one olefinic double bond, in which the homogeneous catalyst system used is separated from the product mixture by means of membrane separation. In a development of the present invention, the ester thus formed is converted to another ester by transesterification and then hydrogenated.
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公开(公告)号：US10457618B2
公开(公告)日：2019-10-29
申请号：US15220135
申请日：2016-07-26
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07C29/92 , A61K31/045 , C07C67/14 , C07C201/12 , C07C29/78 , C07C29/88 , C07C201/16 , A61K31/4188 , A61K45/06 , A61N5/10 , C07C29/86
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
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公开(公告)号：US20190161424A1
公开(公告)日：2019-05-30
申请号：US16091588
申请日：2017-04-07
申请人： A & C FREEMAN
发明人： Andrew FREEMAN
摘要： The present invention relates to a process for treating a glycerol solution comprising fatty acid soaps obtained in a biodiesel production process, to obtain a glycerol enriched phase.
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公开(公告)号：US09932284B2
公开(公告)日：2018-04-03
申请号：US14892436
申请日：2014-05-28
申请人： SHELL OIL COMPANY
发明人： Kai Jürgen Fischer , Wouter Koot , Sipke Hidde Wadman , Jean Paul Andre Marie Joseph Gishlain Lange
IPC分类号： C07C29/86 , C07D307/08 , C07D307/33
CPC分类号： C07C29/86 , C07D307/08 , C07D307/33 , C07C31/207 , C07C31/12
摘要： The present invention provides a process for the recovery of 1,4-butanediol and at least one co-product selected from γ-butyrolactone, n-butanol and tetrahydrofuran from an aqueous stream, said process comprising the steps of providing the aqueous stream, providing a first solvent stream, combining said aqueous stream with said first solvent stream and recovering at least a portion of the 1,4-butanediol and at least a portion of at least one of the co-products by liquid-liquid extraction.
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公开(公告)号：US20170313640A1
公开(公告)日：2017-11-02
申请号：US15524276
申请日：2015-11-04
申请人： SHELL OIL COMPANY
发明人： Pieter HUIZENGA , Kai Jürgen FISCHER , Waldo Eugene DE VILLIERS , Karin BUS , Dorien VELDHUIZEN
CPC分类号： C07C29/86 , B01D11/0426 , B01D11/0492 , B01D2011/002 , C07C31/202 , C07C31/207
摘要： The invention provides a process for the separation of MEG and 1,2-BDO from a first mixture comprising MEG and 1,2-BDO in a first solvent by the steps of: (i) combining said first mixture with a second solvent stream comprising a second solvent in a first extraction column; (ii) recovering (a) a second mixture of MEG and 1,2-BDO in the second solvent, wherein the molar ratio of MEG:1,2-BDO is lower in the second mixture than in the first mixture; and (b) a solution comprising MEG in the first solvent; (iii) combining said second mixture with a first washing stream, said first washing stream also comprising the first solvent in a second extraction column; (iv) recovering (c) a first extract stream comprising the second solvent and 1,2-BDO and (d) a third mixture comprising MEG and, optionally, 1,2-BDO in the first solvent.
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