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公开(公告)号：US11471391B2
公开(公告)日：2022-10-18
申请号：US16877578
申请日：2020-05-19
申请人： NeoPharm Co., Ltd.
发明人： Kyung Sook Yoo , Bu-Mahn Park , Min Hee Kim , Yu Ra Jung , Hye Seong Shin
摘要： Provided are a cosmetic composition for inhibiting sebum hypersecretion and a method of inhibiting sebum hypersecretion using the same. According to the present invention, there may be provided the cosmetic composition of inhibiting and adjusting sebum secretion which is harmless to the human body with excellent skin safety and decreases activity of peroxisome proliferator activated receptor gamma (PPAR-γ) to fundamentally decrease sebum overproduction, thereby providing the skin with an effective effect, and a method of using the same.
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公开(公告)号：US11285119B2
公开(公告)日：2022-03-29
申请号：US16342516
申请日：2017-08-25
申请人： NEOPHARM CO., LTD.
发明人： Ji Yeon Park , Minhee Kim , Bu-Mahn Park , Kyung Sook Yoo , Sung Woo Kim , Hye Seong Shin
IPC分类号： A61K31/16 , A61K8/42 , A61K31/164 , A61K31/198 , A61Q19/00 , A61Q19/08 , A61P17/00 , A61K9/00
摘要： An anti-inflammatory composition is disclosed. The anti-inflammatory composition is be useful for a pharmaceutical composition or a cosmetic composition by not only having excellent stability on the skin and therefore being harmless to the human body, but also by controlling the expression of an inflammatory skin disease-related mediating factor and thereby exhibiting an excellent anti-inflammatory effect.
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公开(公告)号：US11161822B2
公开(公告)日：2021-11-02
申请号：US16877593
申请日：2020-05-19
申请人： NeoPharm Co., Ltd.
发明人： Kyung Sook Yoo , Bu-Mahn Park , Min Hee Kim , Yu Ra Jung , Hye Seong Shin
IPC分类号： C07D233/64 , C07C235/80 , C07D209/20 , C07C279/14
摘要： Provided are a novel amide compound and a use thereof. According to the present invention, there may be provided a use of a novel amide compound which is harmless to the human body with excellent skin stability and decreases activity of peroxisome proliferator activated receptor gamma (PPAR-γ) to fundamentally inhibit sebum overproduction, thereby providing the skin with an effective effect, and a cosmetic composition including the same.
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公开(公告)号：US20210283031A1
公开(公告)日：2021-09-16
申请号：US17198703
申请日：2021-03-11
申请人： Neopharm Co., Ltd.
发明人： Yoon Kim , Kyung Sook Yoo , Bu-Mahn Park , Yu Ra Jung , Hye Seong Shin
摘要： Provided is a cosmetic composition for protection of the skin against reactive oxygen species, ultraviolet rays, or blue light, which includes an amide-based compound. The cosmetic composition according to the present invention can effectively inhibit cell damage caused by the reactive oxygen species, the ultraviolet rays, or the blue light and protect the skin without irritating the skin, and can simultaneously aid in recovering the damaged skin.
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公开(公告)号：US11744791B2
公开(公告)日：2023-09-05
申请号：US17198783
申请日：2021-03-11
申请人： Neopharm Co., Ltd.
发明人： Yoon Kim , Kyung Sook Yoo , Bu-Mahn Park , Yu Ra Jung , Hye Seong Shin
CPC分类号： A61K8/88 , C12N5/0653
摘要： Provided are a cosmetic composition for promoting lipid biosynthesis, a cosmetic composition for inducing differentiation of adipose precursor cells or stem cells into adipocytes, and a cosmetic composition for moisturizing the skin, all of which include an amide-based compound. The cosmetic composition according to the present invention can promote the lipid biosynthesis and can promote expression of PPAR-γ and cluster of differentiation 44, which are markers for labeling human adipose tissue-derived stem cells, to promote differentiation of the adipose tissue-derived stem cells into mature adipocytes, thereby improving a decreased volume and an impaired function of an adipose tissue caused due to the involution of the adipose tissue and giving a synergistic effect to the expression of a skin moisturizing factor.
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公开(公告)号：US11607378B2
公开(公告)日：2023-03-21
申请号：US17198703
申请日：2021-03-11
申请人： Neopharm Co., Ltd.
发明人： Yoon Kim , Kyung Sook Yoo , Bu-Mahn Park , Yu Ra Jung , Hye Seong Shin
摘要： Provided is a cosmetic composition for protection of the skin against reactive oxygen species, ultraviolet rays, or blue light, which includes an amide-based compound. The cosmetic composition according to the present invention can effectively inhibit cell damage caused by the reactive oxygen species, the ultraviolet rays, or the blue light and protect the skin without irritating the skin, and can simultaneously aid in recovering the damaged skin.
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公开(公告)号：US11351131B2
公开(公告)日：2022-06-07
申请号：US16342512
申请日：2017-08-25
申请人： NEOPHARM CO., LTD.
发明人： Ji Yeon Park , Minhee Kim , Bu-Mahn Park , Kyung Sook Yoo , Sung Woo Kim , Hye Seong Shin
IPC分类号： A61K31/195 , A61K9/00 , A61P29/00 , A61Q19/00 , A61Q19/08 , A61K31/164 , A61K8/42
摘要： An anti-inflammatory composition is disclosed. The anti-inflammatory composition is useful for a pharmaceutical composition or a cosmetic composition by not only having excellent stability on the skin and therefore being harmless to the human body, but also by controlling the expression of an inflammatory skin disease-related mediating factor and thereby exhibiting an excellent anti-inflammatory effect.
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公开(公告)号：US11446223B2
公开(公告)日：2022-09-20
申请号：US16095765
申请日：2017-04-07
申请人： NEOPHARM CO., LTD.
发明人： Se Kyoo Jeong , Bu-Mahn Park , Kyung Sook Yoo , Sung Woo Kim , Hye Seong Shin
IPC分类号： A61K8/42 , A61K31/164 , A61K31/165 , A61K31/404 , A61K31/4164 , A61K9/70 , A61K8/49 , A61K9/06 , A61Q19/00 , A61K8/02 , A61P17/00 , A61K8/44 , A61Q19/08 , A61K8/04 , A61K8/19 , A61K8/23 , A61K8/27 , A61K8/31 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/46 , A61K8/58 , A61K8/73 , A61K8/89 , A61K8/891 , A61Q5/00 , A61Q5/12
摘要： The present invention relates to an anti-aging composition. More specifically, the anti-aging composition according to the present invention is highly stable, harmless to the body, and effective in reducing wrinkles and improving elasticity of the skin due to the superb capability for stimulating collagen biosynthesis.
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公开(公告)号：US11345655B2
公开(公告)日：2022-05-31
申请号：US16653464
申请日：2019-10-15
申请人： NEOPHARM CO., LTD.
发明人： Bu-Mahn Park , Hye Seong Shin
IPC分类号： C07C233/18 , C07C233/20 , A61P17/08 , A61Q19/00 , A61K8/42
摘要： Provided are a novel pseudoceramide compound and a skin external composition comprising the same. The skin external composition comprising a pseudoceramide compound or a pharmaceutically acceptable salt or solvate thereof according to the present invention as an active ingredient has an excellent effect of improving a skin barrier function, thereby exhibiting an effect of improving inflammatory skin diseases, and also is excellent in the function of improving the skin barrier and the effect of enhancing skin moisture.
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公开(公告)号：US20210283041A1
公开(公告)日：2021-09-16
申请号：US17198783
申请日：2021-03-11
申请人： Neopharm Co., Ltd.
发明人： Yoon Kim , Kyung Sook Yoo , Bu-Mahn Park , Yu Ra Jung , Hye Seong Shin
摘要： Provided are a cosmetic composition for promoting lipid biosynthesis, a cosmetic composition for inducing differentiation of adipose precursor cells or stem cells into adipocytes, and a cosmetic composition for moisturizing the skin, all of which include an amide-based compound. The cosmetic composition according to the present invention can promote the lipid biosynthesis and can promote expression of PPAR-γ and cluster of differentiation 44, which are markers for labeling human adipose tissue-derived stem cells, to promote differentiation of the adipose tissue-derived stem cells into mature adipocytes, thereby improving a decreased volume and an impaired function of an adipose tissue caused due to the involution of the adipose tissue and giving a synergistic effect to the expression of a skin moisturizing factor.
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