公开(公告)号：US20140309137A1

公开(公告)日：2014-10-16

申请号：US14314088

申请日：2014-06-25

Applicant: NESTEC SA

Inventor： Yuanlong Pan ,  Stephen S. Hannah ,  Rondo P. Middleton

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N2800/044

Abstract: Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

Abstract translation: 公开了与改善或维持的瘦体重或减少的身体脂肪相关的基因表达谱。 在经受瘦素促进方案的动物的脂肪，肝脏和肌肉组织中测定基因表达谱，例如消耗高蛋白饮食，摄入共轭亚麻酸和/或增加运动。 还公开了使用这种简档来鉴定在动物中调节或有助于期望的表型的药物，营养药物，膳食物质或治疗方案的方法