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    METHODS AND FORMULATIONS FOR TREATMENT, REDUCTION, AND PREVENTION OF CANCER IN A COMPANION ANIMAL AND FOR THE REDUCTION OF POSTPRANDIAL BLOOD GLUCOSE IN A COMPANION ANIMAL
    4.
    发明申请
    METHODS AND FORMULATIONS FOR TREATMENT, REDUCTION, AND PREVENTION OF CANCER IN A COMPANION ANIMAL AND FOR THE REDUCTION OF POSTPRANDIAL BLOOD GLUCOSE IN A COMPANION ANIMAL 审中-公开
    用于公司动物治疗，减少和预防癌症的方法和制剂，以及在公司动物中减少血浆葡萄糖

    公开(公告)号：US20160082058A1

    公开(公告)日：2016-03-24

    申请号：US14857253

    申请日：2015-09-17

    Applicant: NESTEC SA

    Inventor： Yuanlong Pan

    IPC: A61K36/02 ,  A61K9/00 ,  A61K47/26 ,  A61K47/42 ,  A61K47/36 ,  A61K36/48 ,  A61K47/14

    CPC classification number: A61K36/02 ,  A23K50/40 ,  A23K50/42 ,  A61K9/0053 ,  A61K9/009 ,  A61K36/03 ,  A61K36/48 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42

    Abstract: The invention provides methods for the treatment of cancer, reduction of cancer risk, or prevention of cancer in a companion animal, comprising: identifying the companion animal having cancer or at risk for cancer and feeding a dietary formulation in a therapeutically effective amount to the animal. The dietary formulation can comprise 20% to 60% protein; 10% to 40% fat; 10% to 50% carbohydrates; and 0.01% to 5% alpha-amylase inhibitor, and optionally 1% to 50% resistant starch. The therapeutically effective amount can be effective for the treatment of cancer, the prevention of cancer, or the reduction of cancer risk in the companion animal by lowering the postprandial blood glucose of the companion animal as compared to the postprandial blood glucose of the companion animal ingesting a comparable dietary formulation that excludes the alpha-amylase inhibitor.

    Abstract translation: 本发明提供了用于治疗癌症，减少癌症风险或预防伴侣动物中的癌症的方法，其包括：鉴定具有癌症或有癌症风险的伴侣动物，并将治疗有效量的膳食制剂喂给动物 。 膳食制剂可以包含20％至60％的蛋白质; 10％至40％的脂肪; 10％至5​​0％碳水化合物; 和0.01％至5％的α-淀粉酶抑制剂和任选的1％至50％抗性淀粉。 与伴侣动物摄食的餐后血糖相比，通过降低伴侣动物的餐后血糖来治疗癌症，预防癌症或降低伴侣动物的癌症风险，治疗有效量是有效的 排除α-淀粉酶抑制剂的可比较的膳食制剂。

    Methods for managing weight loss and body mass
    5.
    发明授权
    Methods for managing weight loss and body mass 有权
    减肥和体重管理方法

    公开(公告)号：US09173426B2

    公开(公告)日：2015-11-03

    申请号：US14600761

    申请日：2015-01-20

    Applicant: Nestec SA

    Inventor： Yuanlong Pan

    IPC: A23L1/29 ,  G09B19/00 ,  A23K1/18

    CPC classification number: A23L1/293 ,  A23K50/40 ,  A23L33/30 ,  A23V2002/00 ,  G09B19/0092

    Abstract: The invention provides methods for promoting weight loss by an animal, promoting weight loss by an animal while preventing or minimizing loss of lean body mass by the animal, preventing a reduction in energy metabolism by an animal, reducing the risk of regaining weight by an animal after weight loss, and ameliorating undesirable animal behaviors associated with reduced caloric intake by intermittently feeding an animal a first diet containing calories that meet the animal's maintenance energy requirements and a second diet containing calories that do not meet the animal's maintenance energy requirements. In preferred embodiments, the described feeding pattern and diets are fed in conjunction with one or more weight loss agents.

    Abstract translation: 本发明提供了促进动物体重减轻的方法，促进了动物的体重减轻，同时防止或最小化动物的瘦体重的损失，防止了动物的能量代谢降低，降低了动物体重的风险 减肥后，通过间歇地给动物喂养含有满足动物维持能量需求的卡路里的第一饮食和含有不符合动物维持能量需求的卡路里的第二饮食来改善与减少热量摄入相关的不期望的动物行为。 在优选的实施方案中，所描述的进食模式和饮食与一种或多种减肥剂一起进料。

    METHODS FOR AMELIORATING SYMPTOMS OR CONDITIONS CAUSED BY STRESS
    6.
    发明申请
    METHODS FOR AMELIORATING SYMPTOMS OR CONDITIONS CAUSED BY STRESS 审中-公开
    用于缓解压力引起的症状或病症的方法

    公开(公告)号：US20140199267A1

    公开(公告)日：2014-07-17

    申请号：US14238237

    申请日：2012-08-07

    Applicant: Nestec SA

    Inventor： Delphine Tissot-Favre ,  Yuanlong Pan

    IPC: A61K31/164 ,  A23K1/18 ,  A23L1/30 ,  A23K1/16

    CPC classification number: A61K31/164 ,  A23K20/158 ,  A23K50/40 ,  A23L33/12 ,  A61K31/16

    Abstract: The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement.

    Abstract translation: 本发明提供了使用脂肪酸链烷醇酰胺改善由压力引起的一种或多种症状或病症的方法，例如食欲不振，或用于维持和增强动物在压力下或经历过压力的营养和热量摄入。 通常，脂肪酸链烷醇酰胺的量在压力之前，期间或之后为约0.1至约1500mg / kg /天，优选作为食物组合物的组分或作为膳食补充剂的常规或每日。

    METHODS AND COMPOSITIONS FOR PRESERVING LEAN BODY MASS AND PROMOTING FAT LOSS DURING WEIGHT LOSS
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR PRESERVING LEAN BODY MASS AND PROMOTING FAT LOSS DURING WEIGHT LOSS 审中-公开
    用于保持体重下降的身体质量和促进脂肪损失的方法和组合物

    公开(公告)号：US20160143324A1

    公开(公告)日：2016-05-26

    申请号：US14946185

    申请日：2015-11-19

    Applicant: Nestec SA

    Inventor： Yuanlong Pan ,  Xui Xu ,  Sandeep Bhatnagar

    IPC: A23K1/18 ,  A23K1/16

    CPC classification number: A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A23K50/40 ,  A23K50/42 ,  A23L33/30

    Abstract: The invention provides compositions and methods for preserving lean body mass and promoting fat loss during weight loss. The methods comprise identifying an animal that is obese or overweight and administering to the animal a food composition in an amount less than the animal's baseline maintenance energy requirement (MER), the food composition comprising from about 30% to about 65% protein, from about 10% to about 20% carbohydrate, and from about 10% to about 25% fat; where the protein and carbohydrate are in a ratio effective for preserving lean body mass and promoting fat loss during administration of the food composition to the animal.

    Abstract translation: 本发明提供了在体重减轻期间保持瘦体重并促进脂肪减少的组合物和方法。 所述方法包括鉴定肥胖或超重的动物，并且以小于动物的基线维持能量需求（MER）的量向动物施用食物组合物，所述食物组合物包含约30％至约65％的蛋白质，来自约 10％至约20％的碳水化合物和约10％至约25％的脂肪; 其中蛋白质和碳水化合物在对食物组合物施用于动物期间具有有效的保留瘦体重并促进脂肪减少的比例。

    COMPOSITIONS AND METHODS FOR ENHANCING MOBILITY OR ACTIVITY OR TREATING FRAILTY
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR ENHANCING MOBILITY OR ACTIVITY OR TREATING FRAILTY 审中-公开
    用于增强移动性或活动或处理FRAILTY的组合物和方法

    公开(公告)号：US20160101081A1

    公开(公告)日：2016-04-14

    申请号：US14879600

    申请日：2015-10-09

    Applicant: NESTEC SA

    Inventor： Yuanlong Pan ,  Janet R. Jackson

    IPC: A61K31/23 ,  A23K1/16 ,  A61K45/06

    CPC classification number: A61K31/23 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A23K20/174 ,  A23K50/42 ,  A23K50/45 ,  A23V2002/00 ,  A61K45/06 ,  A23V2200/302 ,  A23V2250/1944

    Abstract: The present invention provides a method for increasing mobility or activity in an animal or treating or preventing frailty in an animal, comprising identifying an animal with decreased mobility or activity or having frailty and administering a composition comprising one or more medium chain triglycerides (MCTs) to the animal in a therapeutically amount effective for increasing mobility or activity in the animal or treating frailty in the animal. Additionally, a food composition can comprise about 15% to about 50% protein, about 5% to about 40% fat, about 5% to about 50% carbohydrate, and about 1% to about 40% of one or more medium chain triglycerides (MCTs); wherein the composition has a moisture content of about 5% to about 20% and the MCTs are present in a therapeutically amount effective for increasing mobility or activity in the animal or treating frailty in the animal.

    Abstract translation: 本发明提供一种用于增加动物中的迁移率或活性或治疗或预防动物体内虚弱的方法，其包括鉴定具有降低的活动性或具有虚弱的动物，或将包含一种或多种中链甘油三酯（MCT）的组合物施用于 该动物治疗量对于增加动物的运动或活动或治疗动物体内的虚弱有效。 另外，食物组合物可以包含约15％至约50％的蛋白质，约5％至约40％的脂肪，约5％至约50％的碳水化合物和约1％至约40％的一种或多种中链甘油三酯（ MCT）; 其中所述组合物的水分含量为约5％至约20％，并且所述MCT以治疗量存在，所述治疗量对于增加动物中的迁移率或活性或治疗动物体内的虚弱有效。

    GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF
    9.
    发明申请
    GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF 审中-公开
    基因表达与瘦素相关的表型及其用途

    公开(公告)号：US20140309137A1

    公开(公告)日：2014-10-16

    申请号：US14314088

    申请日：2014-06-25

    Applicant: NESTEC SA

    Inventor： Yuanlong Pan ,  Stephen S. Hannah ,  Rondo P. Middleton

    IPC: C12Q1/68

    CPC classification number: C12Q1/6881 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N2800/044

    Abstract: Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

    Abstract translation: 公开了与改善或维持的瘦体重或减少的身体脂肪相关的基因表达谱。 在经受瘦素促进方案的动物的脂肪，肝脏和肌肉组织中测定基因表达谱，例如消耗高蛋白饮食，摄入共轭亚麻酸和/或增加运动。 还公开了使用这种简档来鉴定在动物中调节或有助于期望的表型的药物，营养药物，膳食物质或治疗方案的方法

    METHODS FOR DETERMINING IF AN ANIMAL'S METABOLISM IS KETOGENIC
    10.
    发明申请
    METHODS FOR DETERMINING IF AN ANIMAL'S METABOLISM IS KETOGENIC 审中-公开
    如果动物的代谢是发酵的决定方法

    公开(公告)号：US20140134747A1

    公开(公告)日：2014-05-15

    申请号：US14076364

    申请日：2013-11-11

    Applicant: NESTEC SA

    Inventor： Yuanlong Pan ,  Steven S. Hannah ,  Peichuan Sun ,  Janet R. Jackson

    IPC: G01N33/64

    CPC classification number: G01N33/64 ,  Y10T436/201666

    Abstract: The invention provides methods for determining if an animal's metabolism has been shifted to ketogenic status by collecting a first urine sample from the animal when the animal's metabolism is not in a ketogenic status; collecting a second urine sample from the animal when the animal's metabolism is possibly in a ketogenic status; analyzing the first urine sample and the second urine sample for beta-hydroxy butyrate; and determining that the animal's metabolism has been shifted to ketogenic status if the concentration of beta-hydroxy butyrate in the second urine sample exceeds the concentration of beta-hydroxy butyrate in the first urine sample by ten percent (10%) or more.

    Abstract translation: 本发明提供了当动物的代谢不是酮生成状态时，通过从动物收集第一尿液样品来确定动物的代谢是否已转移到致酮状态的方法; 当动物的代谢可能处于酮症状态时，从动物收集第二个尿样; 分析第一个尿液样品和第二个尿液样品的β-羟基丁酸盐; 如果第二次尿液样品中β-羟基丁酸盐的浓度超过第一个尿液样品中β-羟基丁酸的浓度10％（10％）以上，则确定动物的代谢已转移到酮症状态。

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