公开(公告)号：US10261304B2

公开(公告)日：2019-04-16

申请号：US14597495

申请日：2015-01-15

申请人： NIKON CORPORATION

发明人： Hiroshi Ohki ,  Tomoya Noda ,  Yosuke Okudaira

IPC分类号： H04N7/18 ,  G02B21/36 ,  G02B21/06 ,  G02B27/58

摘要： An acquiring unit of a structured illuminating microscopy apparatus acquires at least two modulated images having the same wave number vector and the different phases; and a calculating unit of the structured illuminating microscopy apparatus, in a spatial frequency spectrum of each of at least the two modulated images acquired by the acquiring unit, separates a 0th-order modulating component and ±first-order modulating components of observational light fluxes superimposed on arbitrary two observation points based on at least four observation values regarding the two observation points which are mutually displaced by an amount of the wave number vector.

公开(公告)号：US10026768B2

公开(公告)日：2018-07-17

申请号：US15270367

申请日：2016-09-20

申请人： NIKON CORPORATION

发明人： Osamu Saruwatari ,  Shigeru Aoki ,  Kazuya Okamoto ,  Isao Sugaya ,  Masashi Okada ,  Hiroshi Ohki

IPC分类号： H01L27/146 ,  H01L25/065 ,  H01L25/07 ,  H01L25/18 ,  H01L31/10 ,  H04N5/3745 ,  H01L25/00 ,  G01S17/89 ,  G01S7/486 ,  G01S7/487 ,  G01S7/491 ,  G01S7/493

摘要： A detector comprises a plurality of photoelectric converters to output an electrical signal corresponding to an incident light, and a plurality of filter circuits provided corresponding to each of the plurality of photoelectric converters or to each of a plurality of element groups respectively including a predetermined number of the photoelectric converters of the plurality of photoelectric converters, the plurality of filter circuits attenuating a signal having a predetermined frequency from the electrical signal output from the plurality of photoelectric converters,In the above-described detector, the plurality of photoelectric converters may be provided in a first substrate, and the plurality of filter circuits may be provided in a second substrate laminated on the first substrate.

公开(公告)号：US11187883B2

公开(公告)日：2021-11-30

申请号：US16290149

申请日：2019-03-01

申请人： NIKON CORPORATION

发明人： Hiroshi Ohki ,  Tomoya Noda ,  Yosuke Okudaira

IPC分类号： G02B27/58 ,  G02B21/06 ,  G02B21/36

摘要： An acquiring unit of a structured illuminating microscopy apparatus acquires at least two modulated images having the same wave number vector and the different phases; and a calculating unit of the structured illuminating microscopy apparatus, in a spatial frequency spectrum of each of at least the two modulated images acquired by the acquiring unit, separates a 0th-order modulating component and ±first-order modulating components of observational light fluxes superimposed on arbitrary two observation points based on at least four observation values regarding the two observation points which are mutually displaced by an amount of the wave number vector.

公开(公告)号：US10451860B2

公开(公告)日：2019-10-22

申请号：US15296442

申请日：2016-10-18

申请人： NIKON CORPORATION

发明人： Hiroshi Ohki

IPC分类号： G02B21/08 ,  G02B21/12 ,  G02B21/14 ,  G02B21/26 ,  G02B21/36 ,  G02F1/1335 ,  G02F1/137

摘要： A microscope system as an optical microscope system for observing a specimen includes: an imaging optical system that forms an image of transmitted light or reflected light from the specimen; an illumination light source that illuminates illumination light on the specimen; an illumination optical system that has a first spatial light modulation element, which changes intensity distribution of the illumination light at a conjugate position of a pupil of the imaging optical system, and illuminates light, which is originated from the illumination light source, on the specimen; an image sensor that detects light through the imaging optical system; and a calculation section that calculates the intensity distribution of the illumination light appropriate for observation of the specimen on the basis of the intensity distribution of the illumination light formed by the first spatial light modulation element and output data detected by the image sensor.

公开(公告)号：US10291831B2

公开(公告)日：2019-05-14

申请号：US15717048

申请日：2017-09-27

申请人： NIKON CORPORATION

发明人： Wataru Funamizu ,  Hiroshi Ohki ,  Shigeru Aoki ,  Naoki Ohkouchi ,  Toru Takagi ,  Yojiro Tezuka ,  Sota Nakanishi

IPC分类号： H04N5/225 ,  G06T1/00 ,  H04N5/232 ,  H04N5/238 ,  H04N9/07 ,  A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  A61B1/313 ,  H04N5/235 ,  H04N5/341 ,  H04N5/351 ,  H04N9/04 ,  H04N1/48

摘要： Provided is an image processing apparatus including as image acquiring section that acquires a plurality of images obtained by imaging, at different times, a subject irradiated with lights intensity-modulated with a plurality of modulation frequencies or modulation frequency bands; and a demodulating section that demodulates pixel values of the plurality of images with a plurality of demodulation frequencies or demodulation frequency bands based on the plurality of modulation frequencies or modulation frequency bands, for each pixel, thereby generating a plurality of pieces of pixel information indicating subject light amounts from the subject caused by each of the lights intensity-modulated with the plurality of modulation frequencies or modulation frequency bands, for each pixel.