公开(公告)号：US10076491B2

公开(公告)日：2018-09-18

申请号：US14166965

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Daisuke Asari ,  Katsuyuki Okubo ,  Takuya Shishido ,  Arimichi Okazaki ,  Yoshiki Maeda ,  Kyohei Matsushita ,  Wenjing Li ,  Mitsuhiko Hori ,  Haruo Sugiyama

IPC: A61K39/00 ,  A61K39/02 ,  A61K45/06 ,  A01N63/00 ,  A61K31/7004 ,  A61K9/00 ,  A61K31/407 ,  A61K31/192 ,  A61K31/405 ,  A61K31/616 ,  A61K31/196 ,  A61K31/415 ,  A61K31/42 ,  A61K31/4035 ,  A61K31/353 ,  A61K31/5575 ,  A61K31/216 ,  A61K31/426 ,  A61K38/10 ,  A61K39/39

CPC classification number: A61K9/0014 ,  A61K31/192 ,  A61K31/196 ,  A61K31/216 ,  A61K31/353 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/407 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/5575 ,  A61K31/616 ,  A61K38/10 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/572

Abstract: The invention provides a vaccine composition containing an antigen for inducing cellular immunity, comprising at least one first cellular immunity induction promoter.

公开(公告)号：US20220372536A1

公开(公告)日：2022-11-24

申请号：US17761373

申请日：2020-09-17

Applicant: BioMedical Research Group Inc. ,  Macrophi Inc. ,  NITTO DENKO CORPORATION

Inventor： Gen-Ichiro Soma ,  Hiroyuki Inagawa ,  Chie Kohchi ,  Kyohei Matsushita ,  Ryo Hashino ,  Wenjing Li

IPC: C12P19/04 ,  C08B37/00 ,  C12N1/20

Abstract: An object of the present invention is to provide a lipopolysaccharide production method that contributes to labor hygiene and environmental conservation and is suited for large-scale production and a lipopolysaccharide produced thereby. The present invention relates to a lipopolysaccharide production method, etc., with which a lipopolysaccharide is extracted and purified from gram-negative bacterium and is a lipopolysaccharide production method that includes a first step of performing extraction from the gram-negative bacterium using hot water to obtain an extract liquid that contains the lipopolysaccharide and a second step of purifying the extract liquid or a solution containing the LPS in the extract liquid by using reverse-phase liquid chromatography to obtain the lipopolysaccharide and in that a reverse-phase column used in the reverse-phase liquid chromatography has a packing material constituted of a material having a functional group of 1 to 8 carbons.

公开(公告)号：US10744197B2

公开(公告)日：2020-08-18

申请号：US15777396

申请日：2016-11-28

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya Shishido ,  Daisuke Asari ,  Eiji Kiyotoh ,  Kyohei Matsushita ,  Wenjing Li ,  Masahiro Fukasaka ,  Katsuyuki Okubo ,  Mitsuhiko Hori

IPC: A61K39/00 ,  C07K14/00 ,  C12N9/90 ,  A61K38/00 ,  A61K39/108 ,  A61K39/145 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K9/19 ,  A61P31/16 ,  A61K47/18

Abstract: The present invention provides a vaccine pharmaceutical composition for oral administration that enables stable storage of an influenza virus antigen and a method for producing the pharmaceutical composition. Provided is a vaccine pharmaceutical composition for oral administration containing an influenza virus antigen, an excipient, a disaccharide, and an amino acid.