公开(公告)号：US09498527B2

公开(公告)日：2016-11-22

申请号：US13856002

申请日：2013-04-03

Applicant: NITTO DENKO CORPORATION ,  OSAKA UNIVERSITY

Inventor： Masahiro Fukasaka ,  Arimichi Okazaki ,  Daisuke Asari ,  Mitsuhiko Hori ,  Shizuo Akira ,  Osamu Takeuchi

IPC: A61K39/39 ,  A61K39/145 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/575 ,  C12N7/00 ,  C12N2710/00034 ,  C12N2760/16034 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412

Abstract: An intraorally administrable vaccine composition useful to be a preventive or therapeutic agent for infectious diseases, and effectively induces a systemic immune response or a mucosal immune response is provided. A vaccine composition for administration to the oral cavity of a human or an animal, the vaccine composition containing at least one antigen derived from an infectious disease, and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic dinucleotide, or a derivative or salt thereof.

Abstract translation: 提供可用于感染性疾病的预防或治疗剂，有效诱导全身免疫应答或粘膜免疫应答的口服给药的疫苗组合物。 一种用于给予人或动物口腔的疫苗组合物，所述疫苗组合物含有至少一种源自感染性疾病的抗原，以及至少一种选自toll样受体4（TLR4）激动剂 ，一种toll样受体2/6（TLR2 / 6）激动剂和环二核苷酸，或其衍生物或盐。