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公开(公告)号：US09498527B2
公开(公告)日：2016-11-22
申请号：US13856002
申请日：2013-04-03
Applicant: NITTO DENKO CORPORATION , OSAKA UNIVERSITY
Inventor： Masahiro Fukasaka , Arimichi Okazaki , Daisuke Asari , Mitsuhiko Hori , Shizuo Akira , Osamu Takeuchi
IPC: A61K39/39 , A61K39/145 , A61K39/12 , A61K39/00
CPC classification number: A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/00034 , C12N2760/16034 , C12N2760/16134 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: An intraorally administrable vaccine composition useful to be a preventive or therapeutic agent for infectious diseases, and effectively induces a systemic immune response or a mucosal immune response is provided. A vaccine composition for administration to the oral cavity of a human or an animal, the vaccine composition containing at least one antigen derived from an infectious disease, and at least one selected from the group consisting of a toll-like receptor 4 (TLR4) agonist, a toll-like receptor 2/6 (TLR2/6) agonist, and cyclic dinucleotide, or a derivative or salt thereof.
Abstract translation: 提供可用于感染性疾病的预防或治疗剂，有效诱导全身免疫应答或粘膜免疫应答的口服给药的疫苗组合物。 一种用于给予人或动物口腔的疫苗组合物，所述疫苗组合物含有至少一种源自感染性疾病的抗原，以及至少一种选自toll样受体4（TLR4）激动剂 ，一种toll样受体2/6（TLR2 / 6）激动剂和环二核苷酸，或其衍生物或盐。
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公开(公告)号：US10206985B2
公开(公告)日：2019-02-19
申请号：US14166970
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION , OSAKA UNIVERSITY
Inventor： Daisuke Asari , Kyohei Matsushita , Arimichi Okazaki , Yoshiki Maeda , Katsuyuki Okubo , Mitsuhiko Hori , Haruo Sugiyama
Abstract: The present invention provides a cancer vaccine composition for mucosal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
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公开(公告)号：US10195258B2
公开(公告)日：2019-02-05
申请号：US14166954
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION , OSAKA UNIVERSITY
Inventor： Yoshiki Maeda , Katsuyuki Okubo , Daisuke Asari , Arimichi Okazaki , Takuya Shishido , Mitsuhiko Hori , Haruo Sugiyama
Abstract: The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.
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公开(公告)号：US10449144B2
公开(公告)日：2019-10-22
申请号：US14166932
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION , OSAKA UNIVERSITY
Inventor： Katsuyuki Okubo , Yoshiki Maeda , Arimichi Okazaki , Daisuke Asari , Takuya Shishido , Mitsuhiko Hori , Haruo Sugiyama
Abstract: The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
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公开(公告)号：US10071051B2
公开(公告)日：2018-09-11
申请号：US14166950
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION , OSAKA UNIVERSITY
Inventor： Katsuyuki Okubo , Yoshiki Maeda , Arimichi Okazaki , Daisuke Asari , Takuya Shishido , Mitsuhiko Hori , Haruo Sugiyama
IPC: A61K9/00 , A61K38/10 , A61K39/00 , A61K31/045 , A61K31/437 , A61K31/451 , A61K31/513 , A61K31/708 , A61K31/716 , A61K31/728 , A61K31/739
CPC classification number: A61K9/0014 , A61K31/045 , A61K31/437 , A61K31/451 , A61K31/513 , A61K31/708 , A61K31/716 , A61K31/728 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K2039/54
Abstract: The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a pharmacologically acceptable acid as a first cellular immunity induction promoter, or a pharmacologically acceptable salt thereof.
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Patent Agency Ranking
公开(公告)号：US11278616B2
公开(公告)日：2022-03-22
申请号：US15932118
申请日：2016-08-03
Applicant: NITTO DENKO CORPORATION
Inventor： Kyohei Matsushita , Daisuke Asari , Takuya Shishido , Mitsuhiko Hori
Abstract: The present invention provides an immunity induction-promoting composition which has a track record of use as a medicine or medicinal additive and is capable of safely and effectively inducing cellular immune response, and a vaccine pharmaceutical composition containing the immunity induction-promoting composition. The present invention relates to an immunity induction-promoting composition containing an immunity induction promoter whose active ingredient is an antimicrobial drug.
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7.发明授权公开(公告)号：US10286067B2
公开(公告)日：2019-05-14
申请号：US15501271
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya Shishido , Daisuke Asari , Kyohei Matsushita , Mitsuhiko Hori
Abstract: The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.
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公开(公告)号：US10092505B2
公开(公告)日：2018-10-09
申请号：US13737255
申请日：2013-01-09
Applicant: NITTO DENKO CORPORATION
Inventor： Daisuke Asari , Mitsuhiko Hori , Takuya Shishido
Abstract: The present invention provides an oral film-form base which has a rapid dissolution profile in the mouth and sufficient film strength, and gives an improved taking property by foaming in the mouth. The oral film-form base includes an edible polymer soluble both in water and in an organic solvent having a solubility parameter of 9.7 or higher, a foaming agent, and an auxiliary foaming agent, wherein the foaming agent is foamable in the presence of water, and the foaming agent and the auxiliary foaming agent each are insoluble in the organic solvent, have an average particle size of 0.1 to 60 μm, and are included in particle states.
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公开(公告)号：US10471141B2
公开(公告)日：2019-11-12
申请号：US15507525
申请日：2015-09-02
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya Shishido , Daisuke Asari , Mitsuhiko Hori
IPC: A61K38/00 , A61K39/00 , A61K39/395 , C07K16/28 , A61K31/198 , A61K39/39 , A61K31/663 , A61K47/54
Abstract: The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of humoral immunity against various antigens and exerting a high antibody production inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing humoral immunity, including: an antigen; and an immunity induction promoter that is a bisphosphonate.
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10.发明授权公开(公告)号：US10369219B2
公开(公告)日：2019-08-06
申请号：US15501271
申请日：2015-08-04
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya Shishido , Daisuke Asari , Kyohei Matsushita , Mitsuhiko Hori
Abstract: The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.
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