公开(公告)号：US11680137B2

公开(公告)日：2023-06-20

申请号：US17042331

申请日：2019-03-26

申请人： NOF CORPORATION

发明人： Koichi Ogi ,  Takuma Tsubusaki ,  Kohei Yoshimura

IPC分类号： C08G65/30 ,  C08G65/324 ,  C08G65/329 ,  C08G65/46 ,  C08G65/48

CPC分类号： C08G65/30 ,  C08G65/324 ,  C08G65/329 ,  C08G65/46 ,  C08G65/48

摘要： A method for purifying a specific trityl group-containing monodispersed polyethylene glycol from a mixture containing the trityl group-containing monodispersed polyethylene glycol and a specific ditritylated impurity. The method includes performing steps (A), (B) and (C). Step (A): a step of esterifying the hydroxyl group of the trityl group-containing monodispersed polyethylene glycol by a specific method; Step (B): a step of extracting the esterified compound by a specific method; and Step (C): a step of hydrolyzing the esterified compound to obtain the trityl group-containing monodispersed polyethylene glycol.

公开(公告)号：US09125821B2

公开(公告)日：2015-09-08

申请号：US14447176

申请日：2014-07-30

申请人： The Regents of the University of California ,  NOF CORPORATION

发明人： Fuyuhiko Tamanoi ,  Jie Lu ,  Kohei Yoshimura ,  Ohyun Kwon ,  Hannah Fiji ,  Masaru Watanabe

IPC分类号： C07D207/48 ,  C07D213/89 ,  A61K31/402 ,  A61K31/4418 ,  A61K9/127 ,  A61K31/40 ,  A61K45/06 ,  C07D207/20 ,  C07D211/96 ,  A61K31/216

CPC分类号： A61K9/127 ,  A61K31/216 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4418 ,  A61K45/06 ,  C07D207/20 ,  C07D207/48 ,  C07D211/96 ,  C07D213/89 ,  A61K2300/00

摘要： The present invention relates, for example, to a liposome, which can be a basic liposome, a transferrin-conjugated liposome, or a pH-sensitive liposome, which encapsulates a compound that specifically inhibits the activity of a protein prenyltransferase, such as a RabGGTase and/or a GGTase I. The liposomes can be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.

摘要翻译： 本发明涉及例如可以是脂质体，其可以是包封特异性抑制蛋白质异戊烯基转移酶的活性的化合物的碱性脂质体，转铁蛋白缀合的脂质体或pH敏感的脂质体，例如RabGGTase 和/或GGT酶I.脂质体可用作抗癌治疗剂，包括作为治疗癌症的方法的一部分，在测定和试剂盒中。

公开(公告)号：US12091502B2

公开(公告)日：2024-09-17

申请号：US16978918

申请日：2019-03-11

申请人： NOF CORPORATION

发明人： Kohei Yoshimura ,  Takuma Tsubusaki ,  Mika Hamura ,  Yuki Matsuno

IPC分类号： C08G65/332 ,  A61K47/68 ,  C08G65/333 ,  C08G65/334

CPC分类号： C08G65/3322 ,  A61K47/68 ,  C08G65/33317 ,  C08G65/334

摘要： A heterobifunctional monodispersed polyethylene glycol represented by the formula (1):




wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule, the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other; R1 is a hydrocarbon group having from 1 to 7 carbon atoms or a hydrogen atom; n is an integer of 3 to 72; 1 is an integer of 2 to 72; and A1, B1 and C1 are as defined herein.

公开(公告)号：US11419946B2

公开(公告)日：2022-08-23

申请号：US16493431

申请日：2018-03-23

申请人： NOF CORPORATION

发明人： Takuma Tsubusaki ,  Kohei Yoshimura ,  Mika Hamura

IPC分类号： A61K47/68 ,  A61K47/60 ,  A61K31/704 ,  C08G65/333 ,  C08G65/329

摘要： A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. R1 is a hydrocarbon group or the like. n is an integer of 3 to 72. A1 represents -L1-(CH2)m1— or the like, L1 and L2 represent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. B1 represents -L3-(CH2)m3— or the like, L3 and L4 represent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.

公开(公告)号：US10092582B2

公开(公告)日：2018-10-09

申请号：US15320695

申请日：2015-06-22

申请人： NOF CORPORATION ,  Yasuhiko Tabata

发明人： Yasuhiko Tabata ,  Kohei Yoshimura

IPC分类号： A61K31/685 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42

摘要： The invention provides a cell mobilizing agent capable of efficiently and continuously accumulating cells involved in tissue repair. In particular, the cell mobilizing agent contains a lysophospholipid introduced with retinoic acid represented by the formula (1) and/or the formula (2) or a physiologically acceptable salt thereof as an active ingredient: wherein R1 and R2 are each a retinoyl group or hydrogen and are not the same.