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公开(公告)号：US20190083680A1
公开(公告)日：2019-03-21
申请号：US16137396
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20180135124A1
公开(公告)日：2018-05-17
申请号：US15571461
申请日：2016-05-09
发明人： Denis DUFRANE
IPC分类号： C12Q1/6881 , C12N5/0775
摘要： The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.
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3.发明申请公开(公告)号：US20210322644A1
公开(公告)日：2021-10-21
申请号：US17273143
申请日：2019-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
IPC分类号： A61L27/38 , A61L27/22 , A61L27/36 , C12N5/0775 , A61P17/02
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), an extracellular matrix and gelatin. The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20200268942A1
公开(公告)日：2020-08-27
申请号：US16646754
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
IPC分类号： A61L27/38 , C12N5/0775 , A61L27/12 , A61L27/36
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a biocompatible material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG). The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20220064729A1
公开(公告)日：2022-03-03
申请号：US17523325
申请日：2021-11-10
发明人： Denis DUFRANE
IPC分类号： C12Q1/6881 , C12N5/0775 , G01N33/74 , G01N33/53 , G01N33/50
摘要： The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.
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公开(公告)号：US20200268939A1
公开(公告)日：2020-08-27
申请号：US16646755
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.
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