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1.发明公开公开(公告)号：US20240000848A1
公开(公告)日：2024-01-04
申请号：US18037630
申请日：2021-11-26
申请人： NOVADIP BIOSCIENCES
发明人： DENIS DUFRANE
IPC分类号： A61K35/28 , A61K31/7105 , A61P35/00
CPC分类号： A61K35/28 , A61K31/7105 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition for use in the prevention and/or the treatment of cancer and/or inflammation, comprising (i) a cellular and/or extracellular extract(s) obtained from a scaffold-free 3-dimensional culture of mature cells and a particulate material, wherein the mature cells secreted an extracellular matrix, and wherein the mature cells and the particulate material were embedded in the extracellular matrix; and (ii) a pharmaceutically acceptable excipient.
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公开(公告)号：US20220409652A1
公开(公告)日：2022-12-29
申请号：US17781150
申请日：2020-11-27
申请人： NOVADIP BIOSCIENCES
发明人： DENIS DUFRANE
IPC分类号： A61K31/7088 , A61P19/08 , A61P19/04
摘要： The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of (i) at least three miRNAs selected in any one of Table 1, Table 2, Table 3, Table 4, Table 5, Table 6, Table 7, Table 8, Table 9, Table 10, Table 11 or Table 12 and (ii) a pharmaceutical acceptable vehicle. The pharmaceutical composition according to the invention may be of therapeutic use for the prevention and/or the treatment of tissue disorders, including, but not limited to skin disorders, bone disorders and/or cartilage disorders.
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公开(公告)号：US20240216572A1
公开(公告)日：2024-07-04
申请号：US17781158
申请日：2020-11-27
申请人： NOVADIP BIOSCIENCES
发明人： DENIS DUFRANE , Nicolas THEYS
IPC分类号： A61L27/12 , A61L27/10 , A61L27/26 , A61L27/36 , A61L27/38 , C08L5/04 , C08L5/08 , C08L5/12 , C08L29/04 , C08L31/06 , C08L39/06 , C08L67/04 , C08L89/06
CPC分类号： A61L27/12 , A61L27/10 , A61L27/26 , A61L27/3633 , A61L27/38 , C08L5/04 , C08L5/08 , C08L5/12 , C08L29/04 , C08L31/06 , C08L39/06 , C08L67/04 , C08L89/06 , A61L2300/414 , A61L2430/34
摘要： The present invention relates to sterile and desiccated biomaterials comprising devitalized differentiated cells having tissue regenerating and/or repairing properties, and a particulate material, the cells and the particulate material being embedded in an extracellular matrix. The particulate material is preferably gelatin, a ceramic material, or a demineralized bone matrix (DBM).
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公开(公告)号：US20190083680A1
公开(公告)日：2019-03-21
申请号：US16137396
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20180135124A1
公开(公告)日：2018-05-17
申请号：US15571461
申请日：2016-05-09
发明人： Denis DUFRANE
IPC分类号： C12Q1/6881 , C12N5/0775
摘要： The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.
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公开(公告)号：US11602579B2
公开(公告)日：2023-03-14
申请号：US16137396
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis Dufrane
IPC分类号： A61K35/28 , A61K38/30 , A61L27/36 , A61L27/10 , A61K38/18 , A61P19/08 , A61K38/19 , A61L27/12 , A61L27/54 , C12N5/077 , A61L27/38 , A61K38/17 , A61L27/46
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a ceramic material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG), and comprises insulin-like growth factor (IGF1) and stromal cell-derived factor 1-alpha (SDF-1α). The present invention also relates to methods for producing the biomaterial and uses thereof.
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7.发明申请公开(公告)号：US20210322644A1
公开(公告)日：2021-10-21
申请号：US17273143
申请日：2019-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
IPC分类号： A61L27/38 , A61L27/22 , A61L27/36 , C12N5/0775 , A61P17/02
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), an extracellular matrix and gelatin. The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20200268942A1
公开(公告)日：2020-08-27
申请号：US16646754
申请日：2018-09-20
申请人： NOVADIP BIOSCIENCES
发明人： Denis DUFRANE
IPC分类号： A61L27/38 , C12N5/0775 , A61L27/12 , A61L27/36
摘要： The present invention relates to a biomaterial comprising adipose-derived stem cells (ASCs), a biocompatible material and an extracellular matrix. In particular, the biomaterial according the present invention secretes osteoprotegerin (OPG). The present invention also relates to methods for producing the biomaterial and uses thereof.
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公开(公告)号：US20220064729A1
公开(公告)日：2022-03-03
申请号：US17523325
申请日：2021-11-10
发明人： Denis DUFRANE
IPC分类号： C12Q1/6881 , C12N5/0775 , G01N33/74 , G01N33/53 , G01N33/50
摘要： The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.
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公开(公告)号：US11203785B2
公开(公告)日：2021-12-21
申请号：US15571461
申请日：2016-05-09
发明人： Denis Dufrane
IPC分类号： C12Q1/6881 , C12N5/0775 , G01N33/74 , G01N33/53 , G01N33/50
摘要： The present invention relates to a method for assessing, evaluating and/monitoring the purity of a mesenchymal stem cells preparation, in particular of an adipose stem cells preparation, comprising measuring the expression level of at least one growth factor.
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