公开(公告)号：US20240360082A1

公开(公告)日：2024-10-31

申请号：US18291083

申请日：2022-07-22

Applicant: NOVARTIS AG

Inventor： Graham Charles BLOOMFIELD ,  Matthew James HESSE ,  Richard Yichong HUANG ,  Michael Robert MASER ,  James Clifford SUTTON ,  Benjamin Robert TAFT ,  David Charles TULLY

IPC: C07D213/82 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/553 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D493/08 ,  C07D493/10 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10

CPC classification number: C07D213/82 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/553 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D493/08 ,  C07D493/10 ,  C07D498/04 ,  C07D498/08 ,  C07D498/10

Abstract: The disclosure provides compounds of Formula (I): (I) as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US20200347072A1

公开(公告)日：2020-11-05

申请号：US16933000

申请日：2020-07-20

Applicant: Novartis AG

Inventor： Rama JAIN ,  Dennis Christofer KOESTER ,  James R. MANNING ,  James Clifford SUTTON ,  Benjamin Robert TAFT ,  Lifeng WAN ,  Qian ZHAO

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.

公开(公告)号：US20190092780A1

公开(公告)日：2019-03-28

申请号：US16083089

申请日：2017-03-07

Applicant: Novartis AG

Inventor： Rama JAIN ,  Dennis Christofer KOESTER ,  James R. MANNING ,  James Clifford SUTTON ,  Benjamin Robert TAFT ,  Lifeng WAN ,  Qian ZHAO

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D513/14 ,  C07D498/14 ,  A61P31/16

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.