公开(公告)号：US10351576B2

公开(公告)日：2019-07-16

申请号：US15569498

申请日：2016-04-29

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D491/052 ,  C07D493/04 ,  A61K31/4162 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/635

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).