公开(公告)号：US10351576B2

公开(公告)日：2019-07-16

申请号：US15569498

申请日：2016-04-29

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D491/052 ,  C07D493/04 ,  A61K31/4162 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/635

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US11021446B2

公开(公告)日：2021-06-01

申请号：US16854762

申请日：2020-04-21

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Runyan Li ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully ,  Xiaoyang Wang ,  Liladhar Murlidhar Waykole ,  Yubo Zhang ,  Bo Zhou

IPC: C07D231/54 ,  C07D471/04 ,  C07D491/052 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4439 ,  A61K31/4745 ,  C07D471/06

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US10683271B2

公开(公告)日：2020-06-16

申请号：US16056881

申请日：2018-08-07

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D231/54 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/4162 ,  C07D471/04 ,  C07D471/06 ,  C07D491/052 ,  A61K31/416

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US20190062283A1

公开(公告)日：2019-02-28

申请号：US16056881

申请日：2018-08-07

Applicant: NOVARTIS AG

Inventor： Donatella CHIANELLI ,  Runyan LI ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Yubo ZHANG ,  Bo ZHOU

IPC: C07D231/54 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/4162 ,  C07D471/04 ,  C07D471/06 ,  C07D491/052 ,  A61K31/416

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US10077240B2

公开(公告)日：2018-09-18

申请号：US15598734

申请日：2017-05-18

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D231/54 ,  A61K31/4745 ,  C07D471/06 ,  A61K31/4162 ,  A61K31/416 ,  C07D491/052 ,  C07D471/04 ,  A61K31/4439

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).