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公开(公告)号：US20230052629A1
公开(公告)日：2023-02-16
申请号：US17352734
申请日：2021-06-21
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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公开(公告)号：US20220112189A1
公开(公告)日：2022-04-14
申请号：US17499663
申请日：2021-10-12
Applicant: Novartis AG
Inventor： Joseph Michael Young , Michael Robert Turner , Peichao Lu
IPC: C07D471/04 , A61K45/06 , A61P33/02
Abstract: The invention relates to compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.
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公开(公告)号：US10975078B2
公开(公告)日：2021-04-13
申请号：US16808985
申请日：2020-03-04
Applicant: Novartis AG
Inventor： Jiping Fu , Wooseok Han , Subramanian Karur , Peichao Lu , Keith Bruce Pfister , Joseph Michael Young
IPC: C07D471/14 , C07D405/12 , A61P31/12 , C07D491/16 , C07D401/12 , A61K45/06 , A61K31/4985 , C07D471/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.
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公开(公告)号：US09845325B2
公开(公告)日：2017-12-19
申请号：US15435137
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Jiping Fu , Xianming Jin , Patrick Lee , Peichao Lu , Joseph Michael Young
IPC: C07D491/147 , C07D471/14 , A61K31/4375
CPC classification number: C07D471/14 , A61K31/4375 , C07D217/08 , C07D491/14 , C07D491/147
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.
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公开(公告)号：US11072610B2
公开(公告)日：2021-07-27
申请号：US16569107
申请日：2019-09-12
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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Patent Agency Ranking
公开(公告)号：US10301312B2
公开(公告)日：2019-05-28
申请号：US15965172
申请日：2018-04-27
Applicant: Novartis AG
Inventor： Jiping Fu , Wooseok Han , Subramanian Karur , Peichao Lu , Keith Bruce Pfister , Joseph Michael Young
IPC: C07D471/14 , C07D405/12 , A61P31/12 , C07D491/16 , C07D401/12 , A61K45/06 , A61K31/4985 , C07D471/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.
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公开(公告)号：US09566312B2
公开(公告)日：2017-02-14
申请号：US14717872
申请日：2015-05-20
Applicant: Novartis AG
Inventor： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
Abstract translation: 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US12018024B2
公开(公告)日：2024-06-25
申请号：US17499663
申请日：2021-10-12
Applicant: Novartis AG
Inventor： Joseph Michael Young , Michael Robert Turner , Peichao Lu
IPC: C07D471/04 , A61K45/06 , A61P33/02
CPC classification number: C07D471/04 , A61K45/06 , A61P33/02
Abstract: The invention relates to compounds of Formula I:
or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.-
公开(公告)号：US20200079772A1
公开(公告)日：2020-03-12
申请号：US16569107
申请日：2019-09-12
Applicant: Novartis AG
Inventor： Christopher Becker , Xiaolin Li , Peichao Lu , Naomi Samadara Rajapaksa , David Charles Tully , Xiaojing Michael Wang , Qian Zhao
IPC: C07D471/04 , A61P31/22
Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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公开(公告)号：US10160726B2
公开(公告)日：2018-12-25
申请号：US15500870
申请日：2015-08-03
Applicant: NOVARTIS AG
Inventor： Javier de Vicente Fidalgo , Haiying He , Cheng Hu , Zhigan Jiang , Xiaolin Li , Peichao Lu , Wosenu Mergo , Daniel Mutnick , Folkert Reck , Alexey Rivkin , Colin Keith Skepper , Xiaojing Michael Wang , Jianhua Xia , Yongjin Xu
IPC: C07D215/38 , C07D215/22 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D419/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D498/10
Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.
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