公开(公告)号：US10660888B2

公开(公告)日：2020-05-26

申请号：US16210968

申请日：2018-12-05

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: A61K31/497 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US09845325B2

公开(公告)日：2017-12-19

申请号：US15435137

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Patrick Lee ,  Peichao Lu ,  Joseph Michael Young

IPC: C07D491/147 ,  C07D471/14 ,  A61K31/4375

CPC classification number: C07D471/14 ,  A61K31/4375 ,  C07D217/08 ,  C07D491/14 ,  C07D491/147

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US09815804B2

公开(公告)日：2017-11-14

申请号：US15375560

申请日：2016-12-12

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume Lapointe ,  Ann Marie Madera ,  Zachary Kevin Sweeney

IPC: C07D261/08 ,  A61K31/42 ,  A61K45/06 ,  C07D413/12 ,  A61K31/422 ,  C07D413/06

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07D413/06 ,  C07D413/12 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  A61K2300/00

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.

公开(公告)号：US20160263113A1

公开(公告)日：2016-09-15

申请号：US15070905

申请日：2016-03-15

Applicant: Novartis AG

Inventor： Shenlin Huang ,  Xianming Jin ,  Zuosheng Liu ,  Daniel Poon ,  John Tellew ,  Yongqin Wan ,  Xing Wang ,  Yongping Xie

IPC: A61K31/506 ,  A61K31/4184

CPC classification number: C07D403/04 ,  A61K9/0053 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

公开(公告)号：US10188649B2

公开(公告)日：2019-01-29

申请号：US15672568

申请日：2017-08-09

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US10029994B2

公开(公告)日：2018-07-24

申请号：US15728351

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume Lapointe ,  Ann Marie Madera ,  Zachary Kevin Sweeney

IPC: C07D261/08 ,  C07D413/12 ,  C07D413/06 ,  A61K31/422 ,  A61K45/06 ,  A61K31/42

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.

公开(公告)号：US09718792B2

公开(公告)日：2017-08-01

申请号：US15454187

申请日：2017-03-09

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume LaPointe ,  Patrick Lee ,  Zachary Kevin Sweeney

IPC: C07D417/10 ,  C07D261/04 ,  A61K31/42 ,  C07D413/04 ,  A61K31/4439 ,  C07D413/10 ,  A61K31/5377 ,  A61K31/427 ,  A61K31/422 ,  A61K45/06

CPC classification number: C07D261/04 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

Abstract: This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.

公开(公告)号：US20220105091A1

公开(公告)日：2022-04-07

申请号：US17551080

申请日：2021-12-14

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Xianming Jin ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: A61K31/4985 ,  A61K47/60 ,  A61P31/20 ,  A01N43/90 ,  A61K38/21 ,  A61K45/06 ,  C07D471/14

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20160280687A1

公开(公告)日：2016-09-29

申请号：US15179644

申请日：2016-06-10

Applicant: Novartis AG

Inventor： Shenlin Huang ,  Xianming Jin ,  Zuosheng Liu ,  Daniel Poon ,  John Tellew ,  Yongqin Wan ,  Xing Wang ,  Yongping Xie

IPC: C07D403/04 ,  C07D401/14 ,  C07D405/14

CPC classification number: C07D403/04 ,  A61K9/0053 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

公开(公告)号：US20160280686A1

公开(公告)日：2016-09-29

申请号：US15179385

申请日：2016-06-10

Applicant: Novartis AG

Inventor： Shenlin Huang ,  Xianming Jin ,  Zuosheng Liu ,  Daniel Poon ,  John Tellew ,  Yongqin Wan ,  Xing Wang ,  Yongping Xie

IPC: C07D403/04 ,  C07D405/14 ,  C07D401/14

CPC classification number: C07D403/04 ,  A61K9/0053 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.