公开(公告)号：US12129246B1

公开(公告)日：2024-10-29

申请号：US18589841

申请日：2024-02-28

Applicant: Novartis AG

Inventor： Daniela Angst ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim Cheung ,  Véronique Darsigny ,  Xiang Gao ,  Viktor Hornak ,  Keith Jendza ,  Rajesh Karki ,  Ajay Kumar Lal ,  Gang Liu ,  Justin Yik Ching Mao ,  Jeffrey M. McKenna ,  Erik Meredith ,  Muneto Mogi ,  Vivek Rauniyar ,  Liansheng Su ,  Ritesh Tichkule ,  Shuangxi Wang ,  Chun Zhang ,  Liang Zhao ,  Rui Zheng

IPC: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US11813306B2

公开(公告)日：2023-11-14

申请号：US17200471

申请日：2021-03-12

Applicant: NOVARTIS AG

Inventor： Karin Briner ,  Brian Addison Dechristopher ,  Alec Nathanson Flyer ,  Andrei Alexandrovich Golosov ,  Philipp Grosche ,  Eugene Yuejin Liu ,  Justin Yik Ching Mao ,  Lauren Gilchrist Monovich ,  Tajesh Jayprakash Patel ,  Liansheng Su ,  Lihua Yang ,  Rui Zheng

IPC: A61K38/12 ,  A61K45/06 ,  C07K5/12

CPC classification number: A61K38/12 ,  A61K45/06 ,  C07K5/126

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):




or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

公开(公告)号：US11026993B2

公开(公告)日：2021-06-08

申请号：US16695843

申请日：2019-11-26

Applicant: NOVARTIS AG

Inventor： Karin Briner ,  Brian Addison Dechristopher ,  Alec Nathanson Flyer ,  Andrei Alexandrovich Golosov ,  Philipp Grosche ,  Eugene Yuejin Liu ,  Justin Yik Ching Mao ,  Lauren Gilchrist Monovich ,  Tajesh Jayprakash Patel ,  Carina Cristina Sanchez ,  Liansheng Su ,  Lihua Yang ,  Rui Zheng

IPC: A61K38/00 ,  A61K38/12 ,  A61K45/06 ,  C07K5/12

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.