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公开(公告)号：US20150374813A1
公开(公告)日：2015-12-31
申请号：US14733632
申请日：2015-06-08
申请人： NOVAVAX, INC.
发明人： Gale SMITH , Rick BRIGHT , Peter M. PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20190038738A1
公开(公告)日：2019-02-07
申请号：US15901000
申请日：2018-02-21
申请人： Novavax, Inc.
发明人： Gale SMITH , Rick BRIGHT , Peter M. PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20130295135A1
公开(公告)日：2013-11-07
申请号：US13890711
申请日：2013-05-09
申请人： Novavax, Inc.
发明人： Gale SMITH , Rick BRIGHT , Peter M. PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20180110851A1
公开(公告)日：2018-04-26
申请号：US15608532
申请日：2017-05-30
申请人： NOVAVAX, INC.
发明人： Gale SMITH , Rick BRIGHT , Peter M. PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20140193447A1
公开(公告)日：2014-07-10
申请号：US14149365
申请日：2014-01-07
申请人： NOVAVAX, INC.
发明人： Gale SMITH , Rick BRIGHT , Peter PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20190314484A1
公开(公告)日：2019-10-17
申请号：US16210501
申请日：2018-12-05
申请人： Novavax, Inc.
发明人： Gale SMITH , Rick BRIGHT , Peter M. PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C12N7/00
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20170252427A1
公开(公告)日：2017-09-07
申请号：US15454820
申请日：2017-03-09
申请人： NOVAVAX, INC.
发明人： Gale SMITH , Rick BRIGHT , Peter PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20160008456A1
公开(公告)日：2016-01-14
申请号：US14869039
申请日：2015-09-29
申请人： NOVAVAX, INC.
发明人： Gale SMITH , Rick BRIGHT , Peter PUSHKO , Jinyou ZHANG , Kutub MAHMOOD
IPC分类号： A61K39/145 , C12N7/00 , A61K39/39
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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