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    Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
    1.
    发明申请
    Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists 审中-公开
    用缺氧诱导因子-1α拮抗剂治疗类风湿性关节炎

    公开(公告)号：US20050148496A1

    公开(公告)日：2005-07-07

    申请号：US10997764

    申请日：2004-11-24

    申请人： Nadine Defranoux ,  Vincent Hurez ,  Seth Michelson ,  Lisl Shoda ,  Leif Wennerberg

    发明人： Nadine Defranoux ,  Vincent Hurez ,  Seth Michelson ,  Lisl Shoda ,  Leif Wennerberg

    IPC分类号： A61K38/17 ,  A61K45/00 ,  A61K45/06 ,  A61K48/00

    CPC分类号： A61K45/06

    摘要： The invention encompasses a novel method of treating inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases and their clinical symptoms. The inventors have made the discovery that the activity of HIF-1α, a transcription regulator known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of HIF-1α.

    摘要翻译： 本发明包括治疗炎性疾病如类风湿性关节炎的新方法，以及鉴定和筛选可用于治疗炎性疾病及其临床症状的药物的新方法。 本发明人已经发现，已知对某些癌症有影响的转录调节因子HIF-1α的活性对类风湿性关节炎的病理生理学具有显着的影响。 可以通过施用抑制HIF-1α活性的化合物来缓解炎性疾病如类风湿性关节炎的症状。