-
公开(公告)号：US20060058988A1
公开(公告)日：2006-03-16
申请号：US11056952
申请日：2005-02-11
申请人： Nadine Defranoux , Todd Dubnicoff , David Klinke , Annette Lewis , Thomas Paterson , Saroja Ramanujan , Lisl Shoda , Karl Soderstrom , Herbert Struemper
发明人： Nadine Defranoux , Todd Dubnicoff , David Klinke , Annette Lewis , Thomas Paterson , Saroja Ramanujan , Lisl Shoda , Karl Soderstrom , Herbert Struemper
CPC分类号： G16H50/50 , A61F2/30756 , A61F2002/30673 , A61F2002/30943 , A61F2002/30952 , G06F19/00 , Y02A90/26
摘要： The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.
-
公开(公告)号：US20070071681A1
公开(公告)日：2007-03-29
申请号：US11377614
申请日：2006-03-15
申请人： Kapil Gadkar , Huub Kreuwel , Thomas Paterson , David Polidori , Saroja Ramanujan , Lisl Katharine Mie Shoda , Chan Whiting , Daniel Young , Yanan Zheng
发明人： Kapil Gadkar , Huub Kreuwel , Thomas Paterson , David Polidori , Saroja Ramanujan , Lisl Katharine Mie Shoda , Chan Whiting , Daniel Young , Yanan Zheng
CPC分类号： G16H50/50 , G01N2800/042 , G06Q50/24 , G16B5/00 , G16B20/00
摘要： The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
摘要翻译： 本发明包括用于开发哺乳动物中1型糖尿病计算机模型的新方法。 特别地，模型可以包括与胰腺淋巴结和一个或多个胰岛相关联的生物过程的表示。 或者，模型可以包括与选自自身反应性T细胞产生，自身反应性T细胞引发，胰岛炎和高血糖的至少两种病症相关的生物学过程的表示。 本发明还提供了开发1型糖尿病非胰岛素替代治疗计算机模型的方法。 本发明还包括1型糖尿病的计算机模型，模拟1型糖尿病的方法和用于模拟1型糖尿病的计算机系统及其用途。
-
公开(公告)号：US20100049492A1
公开(公告)日：2010-02-25
申请号：US12441050
申请日：2007-09-12
申请人： Seema Bajaria , Christina M. Friedrich , Katherine Kudrycki , Cameron Mackay , Thomas Paterson , Saroja Ramanujan , Gregory Shaver
发明人： Seema Bajaria , Christina M. Friedrich , Katherine Kudrycki , Cameron Mackay , Thomas Paterson , Saroja Ramanujan , Gregory Shaver
IPC分类号： G06G7/48
CPC分类号： G01N33/5082 , G16B5/00 , G16H50/50
摘要： The invention encompasses novel computer models of chemical sensitivity of skin and systems for predicting chemical sensitivity of skin. In particular, the computer model of chemical sensitivity of skin comprises a) an epidermal compartment comprising a mathematical representation of exposure of an epidermal tissue to a chemical and a mathematical representation of a first population of antigen presenting cells interacting with the chemical; and b) a lymph node compartment comprising a mathematical representation of a second population of antigen presenting cells, and a mathematical representation of a population of T cells, wherein at least a subpopulation of the population of T cells interacts with the second population of antigen presenting cells.
摘要翻译： 本发明包括用于预测皮肤化学敏感性的皮肤和系统的化学敏感性的新型计算机模型。 特别地，皮肤的化学敏感性的计算机模型包括a）包含表皮组织暴露于化学物质的数学表示的表皮隔室以及与该化学物质相互作用的第一抗原呈递细胞群的数学表示; 和b）包括抗原呈递细胞的第二群体的数学表示的淋巴结隔室，以及T细胞群体的数学表示，其中T细胞群体的至少亚群与第二抗原呈递群体相互作用 细胞。
-
公开(公告)号：US20070026365A1
公开(公告)日：2007-02-01
申请号：US11346990
申请日：2006-02-03
申请人： Christina Friedrich , Anuraag Kansal , David Klinke , Seth Michelson , Thomas Paterson , David Polidori , Jeff Trimmer , Leif Wennerberg
发明人： Christina Friedrich , Anuraag Kansal , David Klinke , Seth Michelson , Thomas Paterson , David Polidori , Jeff Trimmer , Leif Wennerberg
IPC分类号： G09B19/00
CPC分类号： G06Q50/22 , G06F19/324 , G16B5/00 , G16H10/20
摘要： The invention encompasses methods, including computer-implemented methods, of defining a virtual patient population and mapping the virtual patient population to a population of real patients. The invention utilizes virtual measures from one or more virtual patients, and data representative of multiple real subjects in a sample population, such as data collected from patients in a clinical trial or epidemiological study of a real population. The invention includes evaluating the similarity between the virtual patients and the real subjects, and assigning prevalences to the virtual patients based on the evaluation. The similarity can be assessed using some or all of the virtual measures of the virtual patients and some or all of the data obtained for the real subjects. Any of various goodness-of-fit measures can be used to evaluate the similarity or to help identify prevalences. The virtual patient population is defined as the virtual patients according to their respective prevalences.
摘要翻译： 本发明涵盖包括计算机实现的方法，定义虚拟患者人群并将虚拟患者人群映射到真实病人群体的方法。 本发明利用来自一个或多个虚拟患者的虚拟测量，以及代表样本群体中的多个实际受试者的数据，例如在临床试验或对真实人群的流行病学研究中从患者收集的数据。 本发明包括评估虚拟患者与实际受试者之间的相似性，并根据评估将流行率分配给虚拟患者。 可以使用虚拟患者的一些或全部虚拟测量以及为真实对象获得的部分或全部数据来评估相似性。 可以使用任何适合度的措施来评估相似性或帮助确定流行率。 虚拟患者群体根据各自的流行率定义为虚拟患者。
-
公开(公告)号：US07774182B2
公开(公告)日：2010-08-10
申请号：US12208141
申请日：2008-09-10
申请人： Thomas Paterson
发明人： Thomas Paterson
IPC分类号： G06F17/10
CPC分类号： G06F19/12 , G06F9/44505 , G06F17/5009 , G06F19/00 , G16H50/50
摘要： An apparatus and method for validating a computer model is described. In one embodiment, a computer-readable medium comprises instructions to associate a set of configurations of a computer model with a stimulus-response test, each configuration of the set of configurations representing a different model scenario, the stimulus-response test defining a modification to each configuration of the set of configurations. The computer-readable medium also comprises instructions to apply the stimulus-response test to the set of configurations to produce a simulated response for each configuration of the set of configurations and instructions to compare the simulated responses for the set of configurations with an expected response to the stimulus-response test.
摘要翻译： 描述了用于验证计算机模型的装置和方法。 在一个实施例中，计算机可读介质包括将计算机模型的一组配置与刺激 - 响应测试相关联的指令，所述一组配置的每个配置表示不同的模型场景，所述刺激 - 响应测试定义了对 每个配置的一组配置。 所述计算机可读介质还包括将所述刺激响应测试应用于所述一组配置的指令，以针对所述一组配置和指令的每个配置产生模拟响应，以将所述一组配置的模拟响应与预期响应 刺激反应测试。
-
公开(公告)号：US4116958A
公开(公告)日：1978-09-26
申请号：US295890
申请日：1972-10-10
申请人： Alexander Stuart , Thomas Paterson
发明人： Alexander Stuart , Thomas Paterson
IPC分类号： B01J23/00 , B01J25/00 , B01J31/00 , C07B61/00 , C07D239/48 , C07D239/49
CPC分类号： C07D239/48 , C07D239/49
摘要： A method of preparation of 2,4-diamino-5-benzylpyrimidines involving the reaction of a 2,4-diamino-5-substituted methyl pyrimidine, for example 2,4-diamino-5-hydroxymethylpyrimidine, with an appropriately substituted phenol.
-
7.发明授权
公开(公告)号：US4113859A
公开(公告)日：1978-09-12
申请号：US335102
申请日：1973-02-23
IPC分类号： C07D471/04 , C07H19/06 , A61K31/70
CPC分类号： C07D471/04 , C07H19/06
摘要： 8-Substituted pyrido [2,3-d]pyrimidines having activity against microorganisms which utilize de novo synthesis of riboflavin.
-
公开(公告)号：US20060195308A1
公开(公告)日：2006-08-31
申请号：US11305317
申请日：2005-12-16
申请人： Ananth Kadambi , Ganesh Balgi , Thomas Paterson
发明人： Ananth Kadambi , Ganesh Balgi , Thomas Paterson
摘要： The invention encompasses novel methods for developing a computer model of cholesterol metabolism in an animal. In particular, the models include representations of biological processes associated with both lipid flux and lipoprotein particles. The invention also encompasses computer models of cholesterol metabolism, methods of simulating cholesterol metabolism and computer systems for simulating cholesterol metabolism.
摘要翻译： 本发明包括用于开发动物中胆固醇代谢计算机模型的新方法。 特别地，模型包括与脂质通量和脂蛋白颗粒相关联的生物过程的表示。 本发明还包括胆固醇代谢的计算机模型，模拟胆固醇代谢的方法和用于模拟胆固醇代谢的计算机系统。
-
公开(公告)号：US20050131663A1
公开(公告)日：2005-06-16
申请号：US10961523
申请日：2004-10-07
申请人： Alex Bangs , Kevin Bowling , Thomas Paterson
发明人： Alex Bangs , Kevin Bowling , Thomas Paterson
CPC分类号： G16H50/50
摘要： The invention encompasses systems, methods, and apparatus for predicting and monitoring an individual's response to a therapeutic regimen. The invention includes multiple virtual patients, an associating subsystem operable to associate the subject with one or more of the virtual patients, and a simulation engine operable to apply one or more experimental protocols to the one or more virtual patients identified with the subject to generate a set of outputs. The set of outputs can represent therapeutic efficacy, identify biomarkers for monitoring therapeutic efficacy, or merely report the status of the biological system as it represents a particular individual
摘要翻译： 本发明包括用于预测和监测个体对治疗方案的反应的系统，方法和装置。 本发明包括多个虚拟患者，可操作以将受试者与一个或多个虚拟患者相关联的关联子系统，以及可操作以将一个或多个实验协议应用于被识别为受试者的一个或多个虚拟患者以产生 一组输出 该组输出可以代表治疗功效，鉴定用于监测治疗功效的生物标志物，或仅仅报告生物系统的状态，因为它代表特定个体
-
公开(公告)号：US20100324874A9
公开(公告)日：2010-12-23
申请号：US10961523
申请日：2004-10-07
申请人： Alex Bangs , Kevin Bowling , Thomas Paterson
发明人： Alex Bangs , Kevin Bowling , Thomas Paterson
摘要： The invention encompasses systems, methods, and apparatus for predicting and monitoring an individual's response to a therapeutic regimen. The invention includes multiple virtual patients, an associating subsystem operable to associate the subject with one or more of the virtual patients, and a simulation engine operable to apply one or more experimental protocols to the one or more virtual patients identified with the subject to generate a set of outputs. The set of outputs can represent therapeutic efficacy, identify biomarkers for monitoring therapeutic efficacy, or merely report the status of the biological system as it represents a particular individual
摘要翻译： 本发明包括用于预测和监测个体对治疗方案的反应的系统，方法和装置。 本发明包括多个虚拟患者，可操作以将受试者与一个或多个虚拟患者相关联的关联子系统，以及可操作以将一个或多个实验协议应用于被识别为受试者的一个或多个虚拟患者以产生 一组输出 该组输出可以代表治疗功效，鉴定用于监测治疗功效的生物标志物，或仅仅报告生物系统的状态，因为它代表特定个体
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.04 秒)