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公开(公告)号：US07491396B2
公开(公告)日：2009-02-17
申请号：US10542735
申请日：2003-12-18
申请人： Nadine Mothes , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
发明人： Nadine Mothes , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
IPC分类号： A61K39/00 , A61K39/35 , A61K39/36 , A61K38/00 , A01N37/18 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/53
摘要： A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.
摘要翻译： 公开了一种制备来自变应原的低变应原性镶嵌抗原的方法，其中a）在第一步中将变应原分裂成至少两部分，并确定每个部分的IgE反应性，b）在第二步中， 的不具有可检测的IgE反应的变应原组合成包含变应原的氨基酸的马赛克抗原，但是马赛克抗原的氨基酸的顺序与天然存在的变应原的氨基酸的顺序不同。
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公开(公告)号：US20090148466A1
公开(公告)日：2009-06-11
申请号：US12349614
申请日：2009-01-07
申请人： Nadine MOTHES , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
发明人： Nadine MOTHES , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/53
摘要： A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.
摘要翻译： 公开了一种制备来自变应原的低变应原性镶嵌抗原的方法，其中a）在第一步中将变应原分裂成至少两部分，并确定每个部分的IgE反应性，b）在第二步中， 的不具有可检测的IgE反应的变应原组合成包含变应原的氨基酸的马赛克抗原，但是马赛克抗原的氨基酸的顺序与天然存在的变应原的氨基酸的顺序不同。
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公开(公告)号：US20060263391A1
公开(公告)日：2006-11-23
申请号：US10542735
申请日：2003-12-18
申请人： Nadine Mothes , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
发明人： Nadine Mothes , Sabine Stumvoll , Margit Focke , Birgit Linhart , Maria-Theresa Krauth , Peter Valent , Dietrich Kraft , Rudolf Valenta
IPC分类号： A61K39/35 , C07K14/415 , C12N5/04 , C12N15/82
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/53
摘要： A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.
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公开(公告)号：US20120009210A1
公开(公告)日：2012-01-12
申请号：US13179116
申请日：2011-07-08
申请人： Raffaela Campana , Rudolf Valenta , Susanne Vrtala , Ines Swoboda , Anna Gieras , Susanne Spitzauer , Peter Valent , Katharina Blatt , Margarete Focke-Tejkl , Birgit Linhart , Dietrich Kraft
发明人： Raffaela Campana , Rudolf Valenta , Susanne Vrtala , Ines Swoboda , Anna Gieras , Susanne Spitzauer , Peter Valent , Katharina Blatt , Margarete Focke-Tejkl , Birgit Linhart , Dietrich Kraft
IPC分类号： A61K39/36 , C07H21/04 , A61P37/08 , C07K14/415
CPC分类号： C07K14/415 , A61K39/35 , A61K2039/53 , A61K2039/64 , C07K16/16 , C07K2317/76
摘要： Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.
摘要翻译： 本文公开了由天然存在的变应原组装的低过敏性花叶病毒抗原。 还公开了制备这种低变应原性花叶病毒抗原的方法，特别是衍生自植物过敏原如Timothy草花粉（Phl p 1和Phl p 2）和桦树花粉（Bet v 1）的那些。 在特别优选的实施方案中，制备低变应原性镶嵌抗原的方法包括以下步骤：（a）将天然存在的变应原切割成至少两个，优选至少三个非重叠的肽片段，和（b）将肽片段 马赛克抗原包括原始天然存在的变应原的所有或基本上全部的氨基酸，尽管以不同的顺序。
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公开(公告)号：US08709435B2
公开(公告)日：2014-04-29
申请号：US13179116
申请日：2011-07-08
申请人： Raffaela Campana , Rudolf Valenta , Susanne Vrtala , Ines Swoboda , Margarete Focke-Tejkl , Anna Gieras , Susanne Spitzauer , Peter Valent , Katharina Blatt , Birgit Linhart , Dietrich Kraft
发明人： Raffaela Campana , Rudolf Valenta , Susanne Vrtala , Ines Swoboda , Margarete Focke-Tejkl , Anna Gieras , Susanne Spitzauer , Peter Valent , Katharina Blatt , Birgit Linhart , Dietrich Kraft
CPC分类号： C07K14/415 , A61K39/35 , A61K2039/53 , A61K2039/64 , C07K16/16 , C07K2317/76
摘要： Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.
摘要翻译： 本文公开了由天然存在的变应原组装的低过敏性花叶病毒抗原。 还公开了制备这种低变应原性花叶病毒抗原的方法，特别是衍生自植物过敏原如Timothy草花粉（Phl p 1和Phl p 2）和桦树花粉（Bet v 1）的那些。 在特别优选的实施方案中，制备低变应原性镶嵌抗原的方法包括以下步骤：（a）将天然存在的变应原切割成至少两个，优选至少三个非重叠的肽片段，和（b）将肽片段 马赛克抗原包括原始天然存在的变应原的所有或基本上全部的氨基酸，尽管以不同的顺序。
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6.发明申请HYPOALLERGENIC HYBRID POLYPEPTIDES FOR THE TREATMENT OF ALLERGY 有权用于治疗过敏症的HYPOALLERGENIC HYBRID POLYPEPTIDES公开(公告)号：US20120207788A1
公开(公告)日：2012-08-16
申请号：US13395596
申请日：2010-09-09
申请人： Rudolf Valenta , Birgit Linhart , Margarete Focke-Tejkl , Angela Neubauer , Peter Valent , Katharina Blatt
发明人： Rudolf Valenta , Birgit Linhart , Margarete Focke-Tejkl , Angela Neubauer , Peter Valent , Katharina Blatt
IPC分类号： A61K39/35 , C07H21/04 , A61P37/08 , G01N33/566 , C07K14/00
CPC分类号： G01N33/6854 , A61K39/35 , A61K39/36 , C07K14/415 , C07K16/16 , C07K2319/00 , G01N33/505
摘要： The present invention relates to a method for identifying hypoallergenic polypeptides and to a corresponding screening method. The invention further relates to hypoallergenic polypeptides identified by the method of the invention and to the prophylactic and therapeutic use of these polypeptides.
摘要翻译： 本发明涉及鉴定低变应原性多肽的方法和相应的筛选方法。 本发明还涉及通过本发明的方法鉴定的低变应原性多肽以及这些多肽的预防和治疗用途。
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公开(公告)号：US07862828B2
公开(公告)日：2011-01-04
申请号：US10026914
申请日：2001-12-27
申请人： Birgit Linhart , Dietrich Kraft , Rudolf Valenta
发明人： Birgit Linhart , Dietrich Kraft , Rudolf Valenta
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： Hybrid polypeptides comprising at least two different allergenic proteins or fragments thereof wherein each fragment consists of at least eight consecutive amino acids of the respective allergenic protein are disclosed. The hybrid polypeptides and polynucleotides coding therefor can be used as pharmaceutical compositions, in particular as vaccines.
摘要翻译： 包含至少两种不同的过敏原蛋白或其片段的杂交多肽，其中每个片段由相应的变应原蛋白的至少八个连续的氨基酸组成。 杂交多肽和其编码的多核苷酸可以用作药物组合物，特别是作为疫苗使用。
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公开(公告)号：US20110150920A1
公开(公告)日：2011-06-23
申请号：US12954821
申请日：2010-11-26
申请人： Birgit Linhart , Dietrich Kraft , Rudolf Valenta
发明人： Birgit Linhart , Dietrich Kraft , Rudolf Valenta
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： Hybrid polypeptides comprising at least two different allergenic proteins or fragments thereof wherein each fragment consists of at least eight consecutive amino acids of the respective allergenic protein are disclosed. The hybrid polypeptides and polynucleotides coding therefor can be used as pharmaceutical compositions, in particular as vaccines.
摘要翻译： 包含至少两种不同的过敏原蛋白或其片段的杂交多肽，其中每个片段由相应的变应原蛋白的至少八个连续的氨基酸组成。 杂交多肽和其编码的多核苷酸可以用作药物组合物，特别是作为疫苗使用。
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公开(公告)号：US09296828B2
公开(公告)日：2016-03-29
申请号：US12304267
申请日：2007-06-11
申请人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renate Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
发明人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renate Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
IPC分类号： A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/385 , C07H21/02 , C07H21/04 , C12N15/00 , C07K19/00 , C07K14/415
CPC分类号： C07K14/415 , A61K39/35 , A61K39/36 , A61K2039/5256 , A61K2039/5258 , C07K19/00 , C12N2770/32734
摘要： The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
摘要翻译： 本发明涉及由至少一种衍生自变应原的低变应原分子组成的低变应原性蛋白质，其与至少一种第二非致敏性蛋白质或其片段融合或缀合。
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公开(公告)号：US09103835B2
公开(公告)日：2015-08-11
申请号：US13395596
申请日：2010-09-09
申请人： Rudolf Valenta , Birgit Linhart , Margarete Focke-Tejkl , Angela Neubauer , Peter Valent , Katharina Blatt
发明人： Rudolf Valenta , Birgit Linhart , Margarete Focke-Tejkl , Angela Neubauer , Peter Valent , Katharina Blatt
IPC分类号： A61K39/00 , A61K39/35 , A61K39/36 , A61K38/00 , C07K1/00 , C07K14/00 , C07K17/00 , G01N33/68 , C07K14/415 , C07K16/16 , G01N33/50
CPC分类号： G01N33/6854 , A61K39/35 , A61K39/36 , C07K14/415 , C07K16/16 , C07K2319/00 , G01N33/505
摘要： The present invention relates to a method for identifying hypoallergenic polypeptides and to a corresponding screening method. The invention further relates to hypoallergenic polypeptides identified by the method of the invention and to the prophylactic and therapeutic use of these polypeptides.
摘要翻译： 本发明涉及鉴定低变应原性多肽的方法和相应的筛选方法。 本发明还涉及通过本发明的方法鉴定的低变应原性多肽以及这些多肽的预防和治疗用途。
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