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    Method for Identifying Allergenic Proteins And Peptides
    5.
    发明申请
    Method for Identifying Allergenic Proteins And Peptides 有权
    识别过敏原蛋白和肽的方法

    公开(公告)号：US20100143262A1

    公开(公告)日：2010-06-10

    申请号：US12581108

    申请日：2009-10-16

    申请人： Rudolph Valenta ,  Ric Van Tol ,  Udo Herz ,  Heidrun Hochwallner ,  Margarte Focke-Tejkl ,  Ines Swoboda ,  Ulrike Schulmeister

    发明人： Rudolph Valenta ,  Ric Van Tol ,  Udo Herz ,  Heidrun Hochwallner ,  Margarte Focke-Tejkl ,  Ines Swoboda ,  Ulrike Schulmeister

    IPC分类号： A61K49/00 ,  C40B30/06 ,  C07K7/08 ,  C07K14/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  C07K7/06 ,  G01N33/53 ,  A61P37/06

    CPC分类号： G01N33/6854 ,  G01N2500/00 ,  G01N2800/24

    摘要： A method for identifying allergenic proteins and peptides. More specifically, a method for identifying allergenic milk proteins and/or peptides including the steps of: providing at least one expression library comprising DNA or cDNA derived from the mammary gland tissue of a lactating cow, expressing at least one protein or peptide encoded by said expression library, determining the binding capacity of said at least one protein or peptide to IgE of at least one serum of an individual who is sensitive to cow's milk, contacting the at least one protein or peptide exhibiting an IgE binding capacity as determined in step c) with basophil cells, eosinophil cells or mast cells and identifying the at least one protein or peptide as being allergenic when said basophil cells, eosinophil cells or mast cells release upon contact with at least one protein or peptide of step d) at least one mediator.

    摘要翻译： 识别过敏原蛋白和肽的方法。 更具体地，涉及一种用于鉴定过敏性乳蛋白和/或肽的方法，包括以下步骤：提供至少一种表达文库，其包含源自哺乳动物牛乳腺组织的DNA或cDNA，其表达至少一种由所述 表达文库，测定所述至少一种蛋白质或肽与至少一种对牛奶敏感的个体的血清的IgE的结合能力，使与所述至少一种表现IgE结合能力的蛋白质或肽接触，如步骤c ），嗜碱性粒细胞，嗜酸性粒细胞或肥大细胞，并且当所述嗜碱性粒细胞，嗜酸性粒细胞或肥大细胞与步骤d）的至少一种蛋白质或肽接触时释放时，将至少一种蛋白质或肽鉴定为过敏原。至少一种介体 。

    Male germ line cell-specific sequences
    6.
    发明申请
    Male germ line cell-specific sequences 审中-公开
    雄性种系细胞特异性序列

    公开(公告)号：US20050138690A1

    公开(公告)日：2005-06-23

    申请号：US11042574

    申请日：2005-01-24

    申请人： Mohan Singh ,  Prem Bhalla ,  Hui-Ling Xu ,  Ines Swoboda ,  Manjit Singh

    发明人： Mohan Singh ,  Prem Bhalla ,  Hui-Ling Xu ,  Ines Swoboda ,  Manjit Singh

    IPC分类号： C12N15/09 ,  A01H5/00 ,  C07K14/415 ,  C12N5/10 ,  C12N15/29 ,  C12N15/82 ,  A01H1/00 ,  C12N5/04 ,  C12Q1/68

    CPC分类号： C07K14/415 ,  C12N15/8231 ,  C12N15/8289

    摘要： The present invention relates generally to a novel nucleic acid molecule. More particularly, the present invention relates to a male germ line cell specific genetic sequence in plants. Male germ line cells include generative cells and sperm cells. Even more particularly, the present invention provides a male germ line specific gene or functional equivalent thereof. This invention is also directed to the promoter of said gene or its functional derivatives and their use in generating a range of mutant plants including male sterile plants and transposon tagged plants. Preferred nucleic acid molecules of the present invention include the LGC1 gene as well as homologs and derivatives thereof.

    摘要翻译： 本发明一般涉及新的核酸分子。 更具体地说，本发明涉及植物中的雄性种系细胞特异性遗传序列。 雄性生殖细胞包括生殖细胞和精子细胞。 更具体地，本发明提供了雄性种系特异性基因或其功能等同物。 本发明还涉及所述基因的启动子或其功能衍生物及其在产生一系列突变植物（包括雄性不育植物和转座子标记植物）中的用途。 本发明优选的核酸分子包括LGC1基因及其同源物及其衍生物。

    Recombinant allergen with reduced ige binding but undiminished t-cell antigenicity
    8.
    发明申请
    Recombinant allergen with reduced ige binding but undiminished t-cell antigenicity 有权
    重组过敏原具有降低的结合但未减弱的t细胞抗原性

    公开(公告)号：US20050074464A1

    公开(公告)日：2005-04-07

    申请号：US10490305

    申请日：2002-09-13

    申请人： Nicole Deweerd ,  Mohan Singh ,  Prem Bhalla ,  Ines Swoboda

    发明人： Nicole Deweerd ,  Mohan Singh ,  Prem Bhalla ,  Ines Swoboda

    IPC分类号： C12N15/09 ,  A61K39/36 ,  A61P37/08 ,  C07K14/415 ,  C07K16/16 ,  C12N15/13 ,  A61K39/00

    CPC分类号： C07K16/16 ,  A61K39/36 ,  A61K2039/57 ,  A61K2039/577 ,  C07K14/415

    摘要： The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.

    摘要翻译： 本发明一般涉及可用于过敏性疾病的免疫治疗或免疫预防治疗的试剂。 更具体地，本发明提供了改善的变应原，其表现出减少的IgE相互作用，包括降低的IgE产生刺激活性，同时保留了可用于I型过敏性疾病病症的免疫调节的T细胞抗原性。 本发明进一步考虑了通过施用具有降低的IgE相互作用的修饰的变应原同时保留T细胞抗原性的过敏性疾病例如I型过敏性疾病病症的免疫调节的方法。

    Method for identifying allergenic proteins and peptides
    9.
    发明授权
    Method for identifying allergenic proteins and peptides 有权
    识别过敏原蛋白和肽的方法

    公开(公告)号：US08859210B2

    公开(公告)日：2014-10-14

    申请号：US12581108

    申请日：2009-10-16

    申请人： Rudolph Valenta ,  Ric Van Tol ,  Udo Herz ,  Heidrun Hochwallner ,  Margarte Focke-Tejkl ,  Ines Swoboda ,  Ulrike Schulmeister

    发明人： Rudolph Valenta ,  Ric Van Tol ,  Udo Herz ,  Heidrun Hochwallner ,  Margarte Focke-Tejkl ,  Ines Swoboda ,  Ulrike Schulmeister

    IPC分类号： G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6854 ,  G01N2500/00 ,  G01N2800/24

    摘要： A method for identifying allergenic proteins and peptides. More specifically, a method for identifying allergenic milk proteins and/or peptides including the steps of: providing at least one expression library comprising DNA or cDNA derived from the mammary gland tissue of a lactating cow, expressing at least one protein or peptide encoded by said expression library, determining the binding capacity of said at least one protein or peptide to IgE of at least one serum of an individual who is sensitive to cow's milk, contacting the at least one protein or peptide exhibiting an IgE binding capacity as determined in step c) with basophil cells, eosinophil cells or mast cells and identifying the at least one protein or peptide as being allergenic when said basophil cells, eosinophil cells or mast cells release upon contact with at least one protein or peptide of step d) at least one mediator.

    摘要翻译： 识别过敏原蛋白和肽的方法。 更具体地，涉及一种用于鉴定过敏性乳蛋白和/或肽的方法，包括以下步骤：提供至少一种表达文库，其包含源自哺乳动物牛乳腺组织的DNA或cDNA，其表达至少一种由所述 表达文库，测定所述至少一种蛋白质或肽与至少一种对牛奶敏感的个体的血清的IgE的结合能力，使与所述至少一种表现IgE结合能力的蛋白质或肽接触，如步骤c ），嗜碱性粒细胞，嗜酸性粒细胞或肥大细胞，并且当所述嗜碱性粒细胞，嗜酸性粒细胞或肥大细胞与步骤d）的至少一种蛋白质或肽接触时释放时，将至少一种蛋白质或肽鉴定为过敏原。至少一种介体 。