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公开(公告)号：US20090143777A1
公开(公告)日：2009-06-04
申请号：US12297844
申请日：2007-05-23
Applicant: Andrew Pacey , Nagy Habib
Inventor： Andrew Pacey , Nagy Habib
CPC classification number: A61F2/91 , A61B18/1492 , A61B2018/00285 , A61B2018/00577 , A61F2/90 , A61F2/95 , A61F2230/0067
Abstract: A catheter (4) may be introduced into the body of a patient to provide electromagnetic power, such as RF power, directly to a stent (2) to cause heating of surrounding tissue for ablation. The stent may have a conducting portion (14) and insulated portions (13). Struts (15) on the catheter may be deployed by a balloon (103) to contact the stent. The stent may have radial or sector segments (16) which may be individually powered for treating asymmetric tumours.
Abstract translation: 可以将导管（4）引入患者体内以将电力（例如RF功率）直接提供给支架（2）以引起周围组织的加热以进行消融。 支架可以具有导电部分（14）和绝缘部分（13）。 导管上的支柱（15）可以由球囊（103）展开以接触支架。 支架可以具有径向或扇形段（16），其可单独供电用于治疗不对称肿瘤。
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公开(公告)号：US08357153B2
公开(公告)日：2013-01-22
申请号：US12522721
申请日：2008-01-11
Applicant: Nagy Habib
Inventor： Nagy Habib
IPC: A61B18/14
CPC classification number: A61B18/082 , A61B18/1492 , A61B2017/00867 , A61B2018/00214 , A61B2018/00267 , A61B2018/1435 , A61B2018/1467 , A61B2018/1495 , C08L2201/12
Abstract: Devices suitable for insertion into a hollow anatomical structure within a patient for the purpose of ablating tissue within or surrounding the hollow structure so as to induce occlusion of the hollow structure are provided. The devices are in the form of guidewires with functional tips, that comprise at least one heating module, at their distal ends. The devices of the invention are suitable for occluding hollow anatomical structures selected from vasculature or from non-vascular ducts and tubes, via percutaneous, laparoscopic or endoscopic routes of access. Methods of using the devices in the treatment of patients are also described.
Abstract translation: 提供了适于插入到患者体内的中空解剖结构中的装置，用于在中空结构内或周围消融组织以引起中空结构的闭塞。 这些装置是具有功能尖端的导线的形式，其在其远端包括至少一个加热模块。 本发明的装置适合于通过经皮，腹腔镜或内窥镜进入途径闭塞从脉管系统或非血管导管和管中选择的中空解剖结构。 还描述了在患者治疗中使用该装置的方法。
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公开(公告)号：US20100268217A1
公开(公告)日：2010-10-21
申请号：US12301895
申请日：2007-05-23
Applicant: Nagy Habib
Inventor： Nagy Habib
IPC: A61B18/18
CPC classification number: A61B18/1492 , A61B17/12013 , A61B17/2202 , A61B18/24 , A61B2017/00867 , A61B2018/1435 , A61B2018/1467 , A61B2018/1475 , A61B2018/2272 , C08L2201/12
Abstract: A device is provided that is suitable for percutaneous insertion into a hollow vessel, such as a blood vessel, within the body of a patient for purpose of causing endoluminal closure of the vessel at a specified therapeutic site in the body of a patient. The device suitably is in the form of a catheter that is slidably mounted on a guidewire. The catheter may comprise one or more heating modules, as well as one or more extendable structures located on the device and optionally on the associated guidewire, that lead thermal ablation of the vessel walls and subsequent collapse of the vessel. The catheter can function alone or in cooperation with an associated guidewire to induce sealing of the vessel. Methods of using the catheter to treat lesions such as tumours or hemorrhages are also described.
Abstract translation: 提供了一种适于经皮插入患者体内的中空血管（例如血管）的装置，目的是在患者体内的特定治疗部位引起血管内腔封闭。 该装置适合于可滑动地安装在导丝上的导管的形式。 导管可以包括一个或多个加热模块，以及位于装置上并且任选地在相关联的导丝上的一个或多个可延伸结构，其引导血管壁的热消融和随后的血管破裂。 导管可以单独地或与相关联的导丝协作起作用以引起血管密封。 还描述了使用导管治疗诸如肿瘤或出血的病变的方法。
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公开(公告)号：US20100106149A1
公开(公告)日：2010-04-29
申请号：US12522721
申请日：2008-01-11
Applicant: Nagy Habib
Inventor： Nagy Habib
IPC: A61B18/04
CPC classification number: A61B18/082 , A61B18/1492 , A61B2017/00867 , A61B2018/00214 , A61B2018/00267 , A61B2018/1435 , A61B2018/1467 , A61B2018/1495 , C08L2201/12
Abstract: Devices suitable for insertion into a hollow anatomical structure within a patient for the purpose of ablating tissue within or surrounding the hollow structure so as to induce occlusion of the hollow structure are provided. The devices are in the form of guidewires with functional tips, that comprise at least one heating module, at their distal ends. The devices of the invention are suitable for occluding hollow anatomical structures selected from vasculature or from non-vascular ducts and tubes, via percutaneous, laparoscopic or endoscopic routes of access. Methods of using the devices in the treatment of patients are also described.
Abstract translation: 提供了适于插入到患者体内的中空解剖结构中的装置，用于在中空结构内或周围消融组织以引起中空结构的闭塞。 这些装置是具有功能尖端的导线的形式，其在其远端包括至少一个加热模块。 本发明的装置适合于通过经皮，腹腔镜或内窥镜进入途径闭塞从脉管系统或非血管导管和管中选择的中空解剖结构。 还描述了在患者治疗中使用该装置的方法。
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公开(公告)号：US20070274970A1
公开(公告)日：2007-11-29
申请号：US10583188
申请日：2004-12-20
Applicant: Myrtle Gordon , Nagy Habib
Inventor： Myrtle Gordon , Nagy Habib
CPC classification number: C12N5/0607 , A61K2035/124 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2533/78
Abstract: The present invention relates to an isolated stem cell population wherein said stem cells are CD34+, capable of self regeneration, capable of differentiation into ectodermal, mesodermal and endodermal cells and capable of adhering to tissue-culture grade plastic as well as to methods of isolation of said cells, methods of culturing and differentiation thereof, the progeny of such methods of differentiation as well as uses, including therapeutic uses of the stem cells and their differentiated progeny.
Abstract translation: 本发明涉及一种分离的干细胞群，其中所述干细胞是能够自我再生的能够分化为外胚层，中胚层和内胚层细胞并且能够粘附于组织培养级塑料的CD34 +以及分离的干细胞分离方法 所述细胞，培养和分化方法，这些分化方法的后代以及用途，包括干细胞及其分化后代的治疗用途。
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Patent Agency Ranking
公开(公告)号：US20060047274A1
公开(公告)日：2006-03-02
申请号：US10625232
申请日：2003-07-22
Applicant: Nagy Habib , Alan Sangster
Inventor： Nagy Habib , Alan Sangster
IPC: A61B18/18
CPC classification number: A61B18/1815 , A61B18/18 , A61N5/04 , A61N5/045
Abstract: A device for generating localized heating in a selected body tissue includes an applicator having a source of microwave radiation and an array of retractable needles arranged so as to extend from one face of the applicator and, in operation, to confine the irradiated microwave energy field emanating from the applicator. The device has applications for controlling excessive bleeding from severed tissue during surgical procedures.
Abstract translation: 用于在所选择的身体组织中产生局部加热的装置包括具有微波辐射源的施加器和可从所述施用器的一个表面延伸的可伸缩针阵列，并且在操作中限制被辐射的微波能量场 从涂抹器。 该装置具有用于在外科手术期间控制切断的组织的过度出血的应用。
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公开(公告)号：US20130178840A1
公开(公告)日：2013-07-11
申请号：US13712207
申请日：2012-12-12
Applicant: Nagy Habib
Inventor： Nagy Habib
IPC: A61B18/08
CPC classification number: A61B18/082 , A61B18/1492 , A61B2017/00867 , A61B2018/00214 , A61B2018/00267 , A61B2018/1435 , A61B2018/1467 , A61B2018/1495 , C08L2201/12
Abstract: Devices suitable for insertion into a hollow anatomical structure within a patient for the purpose of ablating tissue within or surrounding the hollow structure so as to induce occlusion of the hollow structure are provided. The devices are in the form of guidewires with functional tips, that comprise at least one heating module, at their distal ends. The devices of the invention are suitable for occluding hollow anatomical structures selected from vasculature or from non-vascular ducts and tubes, via percutaneous, laparoscopic or endoscopic routes of access. Methods of using the devices in the treatment of patients are also described.
Abstract translation: 提供了适于插入到患者体内的中空解剖结构中的装置，用于在中空结构内或周围消融组织以引起中空结构的闭塞。 这些装置是具有功能尖端的导线的形式，其在其远端包括至少一个加热模块。 本发明的装置适合于通过经皮，腹腔镜或内窥镜进入途径闭塞从脉管系统或非血管导管和管中选择的中空解剖结构。 还描述了在患者治疗中使用该装置的方法。
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8.发明申请公开(公告)号：US20100331949A1
公开(公告)日：2010-12-30
申请号：US12521516
申请日：2008-01-11
Applicant: Nagy Habib
Inventor： Nagy Habib
CPC classification number: A61B18/1477 , A61B18/1492 , A61B2018/143 , A61F2002/9522 , A61F2002/9528 , A61F2002/9534
Abstract: A removable stent (10) has guide member pairs (16) and loops (20), the guide member pairs being used to align arms of a framework (28) which may expand or collapse the stent. The stent can be retained inside an outer sheath (30) of a catheter (32) with a collapsible filter net (34). Magnetic stents and stents with springs (170) and hinges (156) are also provided.
Abstract translation: 可拆卸支架（10）具有引导构件对（16）和环（20），引导构件对用于对准可扩张或折叠支架的框架（28）的臂。 支架可以用可折叠过滤网（34）保持在导管（32）的外护套（30）内。 还提供了具有弹簧（170）和铰链（156）的磁性支架和支架。
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公开(公告)号：US20060264423A1
公开(公告)日：2006-11-23
申请号：US11419426
申请日：2006-05-19
Applicant: Christopher Wood , Nagy Habib
Inventor： Christopher Wood , Nagy Habib
IPC: A61K31/5415 , A61K31/538
CPC classification number: A61K31/538 , A61K31/5415 , Y02A50/467
Abstract: A method for using thiazine dyes, especially methylene blue or methylene blue derivatives, in an immediate or controlled release formulation, alone or in combination with low levels of light or other drugs, to selectively inactivate or inhibit hepatitis infection, has been developed. Clinical trial results demonstrate efficacy in a human clinical trial for treatment of hepatitis C by oral administration of methylene blue immediate release formulation, in a dosage of 65 mg twice daily, over a period of at least 100 days. A method for using thiazine dyes, especially methylene blue or methylene blue derivatives, in an immediate or controlled release formulation, along or in combination with low levels of light or other drugs, to prevent or decrease reactivation of viruses, is also described. The preferred class of patient is infected with, or has been exposed to, viruses such as Herpes simplex virus type 1 & 2, Varicella zoster virus, Epstein-Barr virus, Cytomegalovirus, and Herpes virus type 6 & 7, Adenovirus, and Human polyoma viruses, e.g. JC virus and BK virus. In one embodiment the thiazine dye is administered to a patient experiencing symptoms or disease caused by reactivation of a virus. In a preferred embodiment the thiazine dye is administered to a patient at risk for or experiencing symptoms or disease caused by reactivation of a virus, prior to or during immunosuppression or chemotherapy.
Abstract translation: 已经开发了将立体或控制释放制剂中的噻嗪染料，特别是亚甲基蓝或亚甲基蓝衍生物单独或与低水平的光或其它药物组合使用以选择性失活或抑制肝炎感染的方法。 临床试验结果表明，通过在至少100天的时间内口服给予亚甲基蓝立即释放制剂的人临床试验用于治疗丙型肝炎的疗效，剂量为65mg，每日两次。 还描述了使用噻嗪染料，特别是亚甲基蓝或亚甲基蓝衍生物在立即或控制释放制剂中，与低水平的光或其它药物一起使用或与低水平的光或其它药物组合的方法，以防止或减少病毒的再活化。 患者的优选类别被感染或已经暴露于病毒如1型和2型单纯疱疹病毒，水痘带状疱疹病毒，爱泼斯坦 - 巴尔病毒，巨细胞病毒和6型和7型疱疹病毒，腺病毒和人多瘤病毒 病毒，例如 JC病毒和BK病毒。 在一个实施方案中，将噻嗪染料施用于经历病毒再活化引起的症状或疾病的患者。 在优选的实施方案中，在免疫抑制或化学疗法之前或期间，向处于或经历由病毒再活化引起的症状或疾病的风险的患者施用噻嗪染料。
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公开(公告)号：US20050143795A1
公开(公告)日：2005-06-30
申请号：US11055858
申请日：2005-02-11
Applicant: Nagy Habib , Alan Sangster
Inventor： Nagy Habib , Alan Sangster
CPC classification number: A61B18/1815 , A61B18/18 , A61N5/04 , A61N5/045
Abstract: A device for restricting the loss of blood during a surgical procedure is disclosed. The device generates localized heating in an organ or volume of tissue and includes an applicator that is positioned against an organ or tissue to be treated, an array of retractable needles that deliver irradiating energy in the vicinity of a selected incision point; a switching mechanism in communication with the needles for energizing and causing movement of the needles and a power unit for supplying irradiating power to the needles when extended into the organ or tissue.
Abstract translation: 公开了一种用于在手术过程中限制血液损失的装置。 该装置在组织的器官或体积中产生局部加热，并且包括针对要治疗的器官或组织定位的施用器，在可选择的切割点附近递送照射能量的可伸缩针阵列; 与针连通的切换机构，用于激发和引起针的移动;以及用于在延伸到器官或组织中时向针提供照射功率的动力单元。
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