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    Method of finding agonist and antagonist to human and rat GPR14
    1.
    发明授权
    Method of finding agonist and antagonist to human and rat GPR14 失效
    寻找人和大鼠GPR14的激动剂和拮抗剂的方法

    公开(公告)号：US6159700A

    公开(公告)日：2000-12-12

    申请号：US232857

    申请日：1999-01-15

    申请人： Nambi V Aiyar ,  Robert S Ames ,  Anne Romanic Arnold ,  Kamal Al-Barazanji ,  Derk J Bergsma ,  Jon Chambers ,  Stephen A Douglas ,  James J Foley ,  Bernard Gout ,  Nassirah Khandoudi ,  Henry M Sarau ,  Usman Shabon ,  Robert N Willette

    发明人： Nambi V Aiyar ,  Robert S Ames ,  Anne Romanic Arnold ,  Kamal Al-Barazanji ,  Derk J Bergsma ,  Jon Chambers ,  Stephen A Douglas ,  James J Foley ,  Bernard Gout ,  Nassirah Khandoudi ,  Henry M Sarau ,  Usman Shabon ,  Robert N Willette

    IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68 ,  G01N33/566 ,  C12N5/06 ,  C12P21/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K14/723

    摘要： Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoictic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers) endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g. RA, Crohn's, IBS); benign prostatic hypertrophy; renal failure and glomerulopathies; disease states, both cardiovascular and non-cardiovascular, which are characterized by excessive vasoconstriction, myocardial dysfunction and/or aberrant fibroproliferative/inflammatory responses; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation, Parkinson's disease, and dyskinesias, infections such as bacterial, fungal, protozoan and viral infections; pain; eating disorders, such as obesity, anorexia, and bulimia; asthma; urinary retention; osteoporosis; allergies; Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人GPR14多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗缺血性冠状动脉疾病（心绞痛和心肌梗死）的方案中使用人GPR14多肽和多核苷酸的方法; 动脉粥样硬化 代谢疾病（如糖尿病）; CHF /心肌功能障碍; 心律不齐 再狭窄; 高血压; 低血压 肺疾病（高血压，COPD，哮喘）; 纤维化血管病变（糖尿病，SLE，AS，Reynaud's）; 脑血管事件（如出血性和缺血性中风）; 神经源性炎症/偏头痛; 造血障碍; ARDS; 癌症; 自身免疫性疾病（如HIV-1和-2感染和艾滋病）; 胃肠道和泌尿生殖系统紊乱（例如溃疡）内分泌紊乱; 纤维增生性疾病（例如牛皮癣）; 炎性疾病（例如RA，克罗恩氏病，IBS）; 良性前列腺肥大; 肾衰竭和肾小球病; 疾病状态，心血管和非心血管疾病，其特征在于血管收缩过度，心肌功能障碍和/或异常纤维增生/炎症反应; 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，严重智力迟钝，帕金森病和运动障碍，细菌，真菌，原生动物和病毒感染等感染; 疼痛; 饮食失调，如肥胖，厌食和贪食症; 哮喘; 尿潴留 骨质疏松症 过敏 亨廷顿氏病或吉尔斯·德拉图雷特综合征等，以及这些病症的诊断测定。