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    Human protein kinase HOACF72
    2.
    发明授权
    Human protein kinase HOACF72 失效
    人类蛋白激酶HOACF72

    公开(公告)号：US5972606A

    公开(公告)日：1999-10-26

    申请号：US802466

    申请日：1997-02-19

    申请人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    发明人： Caretha L. Creasy ,  George P. Livi ,  Damien J. Dunnington ,  Usman Shabon

    IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/54 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C07H21/04 ,  C12N5/00 ,  C12P21/06

    CPC分类号： C12N9/1205 ,  A61K48/00

    摘要： hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndromne (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了通过重组技术生产这种多肽的hYAK1多肽和多核苷酸和方法。 还公开了在设计用于治疗骨丢失（包括骨质疏松症）的方案中使用hYAK1多肽和多核苷酸的方法; 炎性疾病如成人呼吸系统疾病综合征（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘，过敏; 感染如细菌，真菌，原生动物和病毒感染，特别是HIV-1或HIV-2引起的感染; HIV相关性恶病质和其他免疫缺陷病症; 败血性休克 疼痛; 伤害 癌症; 厌食症 贪食 帕金森病 心血管疾病包括再狭窄，动脉粥样硬化，急性心力衰竭，心肌梗塞; 低血压 高血压; 尿潴留 心绞痛; 溃疡 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征，以及此类病症的诊断测定。

    GPR14 polypeptides
    4.
    发明授权
    GPR14 polypeptides 失效
    GPR14多肽

    公开(公告)号：US6133420A

    公开(公告)日：2000-10-17

    申请号：US58725

    申请日：1998-04-10

    申请人： Robert S. Ames, Jr. ,  Henry M. Sarau ,  James J. Foley ,  Usman Shabon ,  Derk Bergsma ,  Jonathan K. Chambers

    发明人： Robert S. Ames, Jr. ,  Henry M. Sarau ,  James J. Foley ,  Usman Shabon ,  Derk Bergsma ,  Jonathan K. Chambers

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/72

    CPC分类号： C07K14/705 ,  C07K14/723 ,  A61K38/00 ,  A61K48/00

    摘要： Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人GPR14多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用人GPR14多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Cloning of a novel G-Protein coupled 7TM receptor
    5.
    发明授权
    Cloning of a novel G-Protein coupled 7TM receptor 失效
    克隆一种新的G蛋白偶联的7TM受体

    公开(公告)号：US5871967A

    公开(公告)日：1999-02-16

    申请号：US788539

    申请日：1997-01-24

    申请人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    发明人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/68 ,  C12R1/91

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HNHCI32多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HNHCI32多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    YAK-1 related serine/threonine protein kinase-HTLAR33
    8.
    发明授权
    YAK-1 related serine/threonine protein kinase-HTLAR33 失效
    YAK-1相关丝氨酸/苏氨酸蛋白激酶-HTLAR33

    公开(公告)号：US06297036B1

    公开(公告)日：2001-10-02

    申请号：US09271815

    申请日：1999-03-18

    申请人： Derk Bergsma ,  Usman Shabon

    发明人： Derk Bergsma ,  Usman Shabon

    IPC分类号： C12N912

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C12Y207/01037

    摘要： HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also, disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

    摘要翻译： 公开了通过重组技术产生这种多肽的HTLAR33多肽和多核苷酸和方法。 还公开了在治疗中利用HTLAR33多肽和多核苷酸的方法，以及用于其的诊断测定法。

    Membrane-type matrix metalloproteinase-5 gene
    9.
    发明授权
    Membrane-type matrix metalloproteinase-5 gene 失效
    膜型基质金属蛋白酶-5基因

    公开(公告)号：US06214600B1

    公开(公告)日：2001-04-10

    申请号：US09090673

    申请日：1998-06-04

    申请人： Anne Romanic Arnold ,  Anthony Joseph Arleth ,  Usman Shabon

    发明人： Anne Romanic Arnold ,  Anthony Joseph Arleth ,  Usman Shabon

    IPC分类号： C12N964

    CPC分类号： C12N9/6491

    摘要： HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arthritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了HCE3P83多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗阿尔茨海默氏病，中风，癌症，炎症，关节炎，肌肉骨骼疾病，心脏病和肾脏疾病的方案中使用HCE3P83多肽和多核苷酸的方法以及用于这些病症的诊断测定法。

    Human neurotensin receptor type 2 and splice variants thereof
    10.
    发明授权
    Human neurotensin receptor type 2 and splice variants thereof 失效
    人类神经降压素受体2型及其剪接变体

    公开(公告)号：US6008050A

    公开(公告)日：1999-12-28

    申请号：US832399

    申请日：1997-04-02

    申请人： Derk Jon Bergsma ,  Usman Shabon

    发明人： Derk Jon Bergsma ,  Usman Shabon

    IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/18 ,  A61P31/04 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/68 ,  C12N15/85 ,  C07H21/02 ,  C07H21/04 ,  C12N15/11

    CPC分类号： C07K14/723 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

    摘要： Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了人神经降压素2型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用人神经降压素2型多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄性痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或吉尔斯·德拉·图雷特综合征，以及这些病症的诊断测定。