公开(公告)号：US08934694B2

公开(公告)日：2015-01-13

申请号：US13824704

申请日：2011-10-03

申请人： Nan-Kuei Chen ,  Alexandru V. Avram ,  Allen W. Song ,  Trong-Kha Truong

发明人： Nan-Kuei Chen ,  Alexandru V. Avram ,  Allen W. Song ,  Trong-Kha Truong

IPC分类号： G06K9/00 ,  G06T11/00 ,  G01R33/565 ,  A61B5/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/561

CPC分类号： G06T11/008 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/7207 ,  G01R33/4824 ,  G01R33/5611 ,  G01R33/5616 ,  G01R33/56509 ,  G01R33/56545 ,  G01R33/56554

摘要： Methods, systems, computer programs, circuits and workstations are configured to carry out image processing to generate MRI images with reduced aliasing artifacts (e.g., Nyquist and/or motion-induced image artifacts) by (a) electronically reconstructing a series of images using patient image data obtained from a patient MRI image data set by iteratively cycling through different estimated values of phase gradients in at least two dimensions; and (b) electronically selecting an image from the reconstructed images as having a lowest artifact level.

摘要翻译： 方法，系统，计算机程序，电路和工作站被配置为通过（a）使用患者电子重建一系列图像来执行图像处理以产生具有减少的混叠伪像（例如，奈奎斯特和/或运动引起的图像伪影）​​的MRI图像 通过在至少两维中反复循环相位梯度的不同估计值从患者MRI图像数据集获得的图像数据; 和（b）从重建图像电子地选择具有最低假象水平的图像。

公开(公告)号：US20130182932A1

公开(公告)日：2013-07-18

申请号：US13824704

申请日：2011-10-03

申请人： Nan-kuei Chen ,  Alexandru V. Avram ,  Allen W. Song ,  Trong-Kha Truong

发明人： Nan-kuei Chen ,  Alexandru V. Avram ,  Allen W. Song ,  Trong-Kha Truong

IPC分类号： G06T11/00

CPC分类号： G06T11/008 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/7207 ,  G01R33/4824 ,  G01R33/5611 ,  G01R33/5616 ,  G01R33/56509 ,  G01R33/56545 ,  G01R33/56554

摘要： Methods, systems, computer programs, circuits and workstations are configured to carry out image processing to generate MRI images with reduced aliasing artifacts (e.g., Nyquist and/or motion-induced image artifacts) by (a) electronically reconstructing a series of images using patient image data obtained from a patient MRI image data set by iteratively cycling through different estimated values of phase gradients in at least two dimensions; and (b) electronically selecting an image from the reconstructed images as having a lowest artifact level.

摘要翻译： 方法，系统，计算机程序，电路和工作站被配置为通过（a）使用患者电子重建一系列图像来执行图像处理以产生具有减少的混叠伪像（例如，奈奎斯特和/或运动引起的图像伪影）​​的MRI图像 通过在至少两维中反复循环相位梯度的不同估计值从患者MRI图像数据集获得的图像数据; 和（b）从重建图像电子地选择具有最低假象水平的图像。

公开(公告)号：US10168410B2

公开(公告)日：2019-01-01

申请号：US13992537

申请日：2011-12-20

申请人： Nan-kuei Chen ,  Trong-Kha Truong ,  Allen W. Song

发明人： Nan-kuei Chen ,  Trong-Kha Truong ,  Allen W. Song

IPC分类号： G01R33/561 ,  G01R33/58 ,  G01R33/563 ,  G01R33/565

摘要： Methods, systems, computer programs, circuits and workstations are configured to generate MRI images using gradient blips for signal acquisition and reconstruction using dynamic field mapping, TE corrections and/or multischeme partial Fourier images.

公开(公告)号：US20130249555A1

公开(公告)日：2013-09-26

申请号：US13992537

申请日：2011-12-20

申请人： Nan-kuei Chen ,  Trong-Kha Truong ,  Allen W. Song

发明人： Nan-kuei Chen ,  Trong-Kha Truong ,  Allen W. Song

IPC分类号： G01R33/58

CPC分类号： G01R33/583 ,  G01R33/561 ,  G01R33/5616 ,  G01R33/56341 ,  G01R33/56518 ,  G01R33/56536 ,  G01R33/56554

摘要： Methods, systems, computer programs, circuits and workstations are configured to generate MRI images using gradient blips for signal acquisition and reconstruction using dynamic field mapping, TE corrections and/or multischeme partial Fourier images.

摘要翻译： 方法，系统，计算机程序，电路和工作站被配置为使用梯度波形来生成MRI图像，用于使用动态场映射，TE校正和/或多图像部分傅里叶图像进行信号采集和重建。

公开(公告)号：US20090088578A1

公开(公告)日：2009-04-02

申请号：US12017608

申请日：2008-01-22

申请人： Christopher D. Lascola ,  Allen W. Song ,  Timothy A. Haystead

发明人： Christopher D. Lascola ,  Allen W. Song ,  Timothy A. Haystead

IPC分类号： A61K49/10 ,  C07D209/04 ,  A61B5/055

CPC分类号： A61K49/10 ,  A61B5/055 ,  A61B5/416

摘要： Imaging agents for magnetic resonance imaging are disclosed. Also disclosed are methods of non-invasively generating a visible image of a target tissue. In some embodiments, the discloses methods include the steps of (a) providing a contrast enhancement agent comprising a small molecule that binds to a biomolecule present in the target tissue; (b) introducing the contrast enhancement agent into the target tissue; and (c) scanning the target tissue using magnetic resonance imaging, whereby a visible image of the target tissue is non-invasively generated. Further discloses are methods for monitoring a response to a therapy, methods for selecting a therapy for a subject, methods for delineating a boundary between a diseased cell and a non-diseased cell in a tissue, and methods for assessing the degree to which a target tissue has been removed from a subject.

摘要翻译： 公开了用于磁共振成像的成像剂。 还公开了非侵入性地产生目标组织的可见图像的方法。 在一些实施方案中，所公开的方法包括以下步骤：（a）提供包含结合靶组织中存在的生物分子的小分子的造影增强剂; （b）将对比度增强剂引入靶组织; 和（c）使用磁共振成像扫描目标组织，从而非侵入性地产生目标组织的可视图像。 进一步公开的是用于监测对治疗的反应的方法，用于选择受试者的治疗的方法，用于描绘病变细胞和组织中的非病变细胞之间的边界的方法，以及用于评估靶的程度的方法 组织已从受试者中移除。

公开(公告)号：US06618607B2

公开(公告)日：2003-09-09

申请号：US09978514

申请日：2001-10-15

申请人： Allen W. Song

发明人： Allen W. Song

IPC分类号： A61B505

CPC分类号： G01R33/4806 ,  G01R33/482 ,  G01R33/5615 ,  G01R33/5616 ,  G01R33/56536

摘要： Signal recovery in functional magnetic resonance imaging (fMRI) is provided by generating a single excitation pulse and exciting a target region of a subject with the generated excitation pulse. A first image is obtained using a first partial k-space frame of the target region. A compensation pulse is generated and the target region excited with the compensation pulse. A second, compensated, image is obtained subsequent to the excitation by the compensation pulse using a second partial k-space frame of the target region. The first and second images are combined to form a combined image of the target region. The first and second obtaining steps are carried out sequentially during a single quadratic excitation pulse.