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    Method of identifying inhibitors of Tie-2
    1.
    发明授权
    Method of identifying inhibitors of Tie-2 失效
    识别Tie-2抑制剂的方法

    公开(公告)号：US07369946B2

    公开(公告)日：2008-05-06

    申请号：US09815341

    申请日：2001-03-22

    申请人： Nancy J. Bump ,  Lee D. Arnold ,  Richard W. Dixon ,  Hans Wolfgang Hoeffken ,  Karen Allen ,  Cornelia Bellamacina

    发明人： Nancy J. Bump ,  Lee D. Arnold ,  Richard W. Dixon ,  Hans Wolfgang Hoeffken ,  Karen Allen ,  Cornelia Bellamacina

    IPC分类号： G06F19/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K2299/00

    摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.

    摘要翻译： 本发明涉及包含Tie-2的配体结合结构域，这些多肽的结晶形式以及这些结晶形式用于确定Tie-2催化结构域的三维结构的多肽。 本发明还涉及在设计和/或鉴定Tie-2活性的潜在抑制剂的方法中单独或与抑制剂复合的Tie-2催化结构域的三维结构的用途，例如抑制 天然底物与Tie-2催化结构域的结合。