公开(公告)号：US20140170232A1

公开(公告)日：2014-06-19

申请号：US14186993

申请日：2014-02-21

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Darrel L. Holmes ,  Michael Mansfield

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Darrel L. Holmes ,  Michael Mansfield

IPC分类号： A61L27/36 ,  A61L27/54

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

摘要翻译： 通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。 以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。 当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

公开(公告)号：US20150202346A1

公开(公告)日：2015-07-23

申请号：US14672763

申请日：2015-03-30

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A61L27/36 ,  A61L27/56 ,  A61L27/22

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

摘要翻译： 通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。 以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。 当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

公开(公告)号：US08992964B2

公开(公告)日：2015-03-31

申请号：US13453818

申请日：2012-04-23

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A61F2/02 ,  A61L27/36 ,  A61F2/46 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  C12N5/00

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

摘要翻译： 通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。 以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。 当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

公开(公告)号：US20080305145A1

公开(公告)日：2008-12-11

申请号：US12130384

申请日：2008-05-30

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A61K9/00 ,  C12N5/00 ,  A61K35/12 ,  C12Q1/02 ,  A61P43/00

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

摘要翻译： 通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。 以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。 当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

公开(公告)号：US20150258244A1

公开(公告)日：2015-09-17

申请号：US14672727

申请日：2015-03-30

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61L27/28 ,  A61L27/54

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

公开(公告)号：US20120213859A1

公开(公告)日：2012-08-23

申请号：US13453818

申请日：2012-04-23

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A61K35/32 ,  A61P19/00

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

摘要翻译： 通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。 以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。 当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

公开(公告)号：US08574825B2

公开(公告)日：2013-11-05

申请号：US12130384

申请日：2008-05-30

申请人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

发明人： Nancy J. Shelby ,  Steven M. Scott ,  Benjamin P. Luchsinger ,  Gregory A. Juda ,  Kelly R. Kirker ,  Jesus Hernandez ,  Darrel L. Holmes

IPC分类号： A01N1/00

CPC分类号： A61L27/3608 ,  A61F2/4644 ,  A61L27/227 ,  A61L27/28 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2420/00 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2503/02 ,  C12N2533/90 ,  C12N2537/00

摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

公开(公告)号：US20110171321A1

公开(公告)日：2011-07-14

申请号：US13062918

申请日：2009-09-11

申请人： Benjamin P. Luchsinger ,  Todd R. Meyer

发明人： Benjamin P. Luchsinger ,  Todd R. Meyer

IPC分类号： A01N59/16 ,  A01P1/00

CPC分类号： A61L27/54 ,  A01N59/16 ,  A61L2300/104 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A01N25/02 ,  A01N25/34 ,  A01N2300/00

摘要： A method for impregnating a polymer with a bioactive material includes preparing a bioactive metal solution having a bioactive metal, a first solvent in which the bioactive metal is insoluble and a second solvent in which the bioactive metal is slightly soluble. The method also includes soaking the polymer in the bioactive metal solution. Another method for impregnating a polymer with a bioactive material includes soaking the polymer in a swelling solvent followed by soaking the polymer in a bioactive metal solution having the bioactive metal and a solvent in which the bioactive metal is slightly soluble. A bioactive metal-impregnated polymer is prepared by soaking a polymer in a saturated bioactive metal solution comprising a bioactive metal, a swelling solvent in which the bioactive metal is insoluble, and a second solvent in which the bioactive metal is slightly soluble.

摘要翻译： 用生物活性材料浸渍聚合物的方法包括制备具有生物活性金属的生物活性金属溶液，其中生物活性金属不溶的第一溶剂和其中生物活性金属微溶的第二溶剂。 该方法还包括将聚合物浸泡在生物活性金属溶液中。 用生物活性材料浸渍聚合物的另一种方法包括将聚合物浸泡在溶胀溶剂中，随后将聚合物浸泡在具有生物活性金属的生物活性金属溶液和其中生物活性金属微溶于其中的溶剂中。 通过将聚合物浸泡在包含生物活性金属，其中生物活性金属不溶解的溶胀溶剂和其中生物活性金属微溶的第二溶剂的饱和生物活性金属溶液中来制备生物活性金属浸渍的聚合物。