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公开(公告)号：US20050037946A1
公开(公告)日：2005-02-17
申请号：US10753267
申请日：2004-01-08
申请人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
发明人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
CPC分类号： C07K14/47
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
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2.发明申请Methods and compositions for treating hematological disorders using 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 or 5014 审中-公开使用9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943,2061的治疗血液病症的方法和组合物， 5891,9137,13908,14310,17600,25584,27824,28469,38947,53003,965,56639,961,61652,1521,6662,13913,12405或5014公开(公告)号：US20050042687A1
公开(公告)日：2005-02-24
申请号：US10772636
申请日：2004-02-05
申请人： Louise Kelly , Joseph Carroll , Deborah Farlow , Aileen Healy
发明人： Louise Kelly , Joseph Carroll , Deborah Farlow , Aileen Healy
IPC分类号： A61K38/00 , C07K14/47 , G01N33/53 , A61K39/395 , G01N33/567
摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.
摘要翻译： 本发明涉及诊断和治疗血液学疾病的方法。 具体而言，本发明鉴定了9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943的差异表达， 2061,5981,9137,13908,14310,1769,25584,27824,28469,38947,53003,965,5666,99661,16052,1521,6662,13913,12405和5014与血液学疾病感觉有关的组织中的基因，相对于 它们在正常或非血液学疾病疾病状态中的表达，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。
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公开(公告)号：US07250262B2
公开(公告)日：2007-07-31
申请号：US10352684
申请日：2003-01-28
IPC分类号： G01N33/53
CPC分类号： G01N33/9413 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 and 13249 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.
摘要翻译： 本发明涉及诊断和治疗血液病症的方法。 具体地，本发明鉴定131,148,199,12303,13906,15513,17822,302,5677,194,14393,28059,7366,121212,1981,261,12416,270,1410,137的差异表达， 1871,13051,1847,1849,15402,340,10217,837,1761,8990和13249涉及血液学疾病感觉的组织中的基因，相对于它们在正常或非血液学疾病疾病状态中的表达和/或应答 与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。
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4.发明申请Methods and compositions for treating hematological disorders using 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 or 5014 审中-公开使用9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943,2061的治疗血液病症的方法和组合物， 5891,9137,13908,14310,17600,25584,27824,28469,38947,53003,965,56639,961,61652,1521,6662,13913,12405或5014公开(公告)号：US20060078947A1
公开(公告)日：2006-04-13
申请号：US11288493
申请日：2005-11-29
申请人： Louise Kelly , Joseph Carroll , Deborah Farlow , Aileen Healy
发明人： Louise Kelly , Joseph Carroll , Deborah Farlow , Aileen Healy
IPC分类号： G01N33/567 , G01N33/53
摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.
摘要翻译： 本发明涉及诊断和治疗血液学疾病的方法。 具体而言，本发明鉴定了9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943的差异表达， 2061,5981,9137,13908,14310,1769,25584,27824,28469,38947,53003,965,5666,99661,16052,1521,6662,13913,12405和5014与血液学疾病感觉有关的组织中的基因，相对于 它们在正常或非血液学疾病疾病状态中的表达，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。
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公开(公告)号：US08753833B2
公开(公告)日：2014-06-17
申请号：US12665794
申请日：2008-06-19
CPC分类号： C07K14/001 , G01N33/5008 , G01N2333/52
摘要： The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.
摘要翻译： 本发明提供用于评估氨基酸共聚物的一种或多种性质的方法和组合物。
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公开(公告)号：US20110053203A1
公开(公告)日：2011-03-03
申请号：US12665794
申请日：2008-06-19
IPC分类号： C12Q1/02
CPC分类号： C07K14/001 , G01N33/5008 , G01N2333/52
摘要： The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.
摘要翻译： 本发明提供用于评估氨基酸共聚物的一种或多种性质的方法和组合物。
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7.发明申请Methods and compositions for treating hematological disorders using 232, 2059, 10630, 12848, 13875, 14395, 14618, 17692, 58874, 252, 304, 1980, 14717, 9941, 1941, 19310, or 17832 审中-公开使用232,2059,10630,12848,13875,14395,14618,17782,58874,252,304,1980,14717,9941,1941,199310或17832来治疗血液病症的方法和组合物公开(公告)号：US20060099656A1
公开(公告)日：2006-05-11
申请号：US11242505
申请日：2005-10-03
申请人： Joseph Carroll , Aileen Healy
发明人： Joseph Carroll , Aileen Healy
IPC分类号： G01N33/567
CPC分类号： G01N33/6893 , G01N2800/22 , Y02A50/58
摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 232, 2059, 10630, 12848, 13875, 14395, 14618, 17692, 58874, 252, 304, 1980, 14717, 9941, 19310, or 17832 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.
摘要翻译： 本发明涉及诊断和治疗血液学疾病的方法。 具体地，本发明鉴定了与血液学疾病感觉有关的组织中的232,2059,10630,12848,13875,14395,14618,17712,58874,252,304,1980,14717,9941,19310或17832基因的差异表达 相对于它们在正常或非血液学疾病疾病状态中的表达，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。
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