Protein kinase molecules and uses therefor
    2.
    发明授权
    Protein kinase molecules and uses therefor 有权
    蛋白激酶分子及其用途

    公开(公告)号:US06183962B2

    公开(公告)日:2001-02-06

    申请号:US09163115

    申请日:1998-09-29

    申请人: Susan Acton

    发明人: Susan Acton

    IPC分类号: C12N912

    摘要: The invention provides isolated nucleic acid molecules, designated CSAPK-1 nucleic acid molecules, which encode novel cardiovascular system associated protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing CSAPK-1 polypeptides.

    摘要翻译: 本发明提供编码新的心血管系统相关蛋白激酶的分离的核酸分子,命名为CSAPK-1核酸分子。 本发明还提供反义核酸分子,含有CSAPK-1核酸分子的重组表达载体,其中引入了表达载体的宿主细胞,以及产生CSAPK-1多肽的方法。

    Novel protein kinase molecules and uses therefor
    4.
    发明申请
    Novel protein kinase molecules and uses therefor 审中-公开
    新型蛋白激酶分子及其用途

    公开(公告)号:US20080050840A1

    公开(公告)日:2008-02-28

    申请号:US11893477

    申请日:2007-08-16

    申请人: Susan Acton

    发明人: Susan Acton

    IPC分类号: G01N33/53 C07K16/00

    摘要: The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CSAPK gene has been introduced or disrupted. The invention still further provides isolated CSAPK proteins, fusion proteins, antigenic peptides and anti-CSAPK antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 本发明提供编码新型蛋白激酶的分离的核酸分子,命名为CSAPK核酸分子。 本发明还提供反义核酸分子,含有CSAPK核酸分子的重组表达载体,其中引入了表达载体的宿主细胞,以及其中引入或破坏了CSAPK基因的非人类转基因动物。 本发明还进一步提供了分离的CSAPK蛋白,融合蛋白,抗原肽和抗CSAPK抗体。 还提供了利用本发明组合物的诊断,筛选和治疗方法。

    ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR
    7.
    发明申请
    ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR 审中-公开
    ANGIOTENSIN转化酶同源异构体及其用途

    公开(公告)号:US20100273989A1

    公开(公告)日:2010-10-28

    申请号:US12340815

    申请日:2008-12-22

    IPC分类号: C07K16/18

    摘要: The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions.

    摘要翻译: 本发明涉及编码血管紧张素转换酶血管紧张素转化酶-2(ACE-2)的新基因的发现。 本发明提供了用于治疗血压相关疾病以及各种类型的变态反应病症的治疗,预后和诊断方法。 还公开了用于鉴定用于治疗和预防这些病症的化合物的筛选测定。

    Phospholipase molecule and uses therefor
    8.
    发明授权
    Phospholipase molecule and uses therefor 失效
    磷脂酶分子及其用途

    公开(公告)号:US06268135B1

    公开(公告)日:2001-07-31

    申请号:US09163833

    申请日:1998-09-30

    申请人: Susan Acton

    发明人: Susan Acton

    IPC分类号: C12Q168

    CPC分类号: C12Y301/03048 C12N9/16

    摘要: Novel CSAPL polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length CSAPL proteins, the invention further provides isolated CSAPL fusion proteins, antigenic peptides and anti-CSAPL antibodies. The invention also provides CSAPL nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CSAPL gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 公开了新型CSAPL多肽,蛋白质和核酸分子。 除了分离的全长CSAPL蛋白之外,本发明还提供了分离的CSAPL融合蛋白,抗原肽和抗CSAPL抗体。 本发明还提供CSAPL核酸分子,含有本发明的核酸分子的重组表达载体,已经引入了表达载体的宿主细胞和其中CSAPL基因被引入或破坏的非人转基因动物。 还提供利用本发明组合物的诊断,筛选和治疗方法。

    CSAPTP nucleic acid molecules and uses therefor
    9.
    发明授权
    CSAPTP nucleic acid molecules and uses therefor 失效
    CSAPTP核酸分子及其用途

    公开(公告)号:US06258582B1

    公开(公告)日:2001-07-10

    申请号:US09164193

    申请日:1998-09-30

    申请人: Susan Acton

    发明人: Susan Acton

    IPC分类号: C12N916

    CPC分类号: C12Y301/03048 C12N9/16

    摘要: Novel CSAPTP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length CSAPTP proteins, the invention further provides isolated CSAPTP fusion proteins, antigenic peptides and anti-CSAPTP antibodies. The invention also provides CSAPTP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CSAPTP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译: 公开了新型CSAPTP多肽,蛋白质和核酸分子。 除了分离的全长CSAPTP蛋白之外,本发明还提供了分离的CSAPTP融合蛋白,抗原肽和抗CSAPTP抗体。 本发明还提供了CSAPTP核酸分子,含有本发明的核酸分子的重组表达载体,已经引入了表达载体的宿主细胞和已引入或破坏了CSAPTP基因的非人转基因动物。 还提供利用本发明组合物的诊断,筛选和治疗方法。