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公开(公告)号：US20050037946A1
公开(公告)日：2005-02-17
申请号：US10753267
申请日：2004-01-08
申请人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
发明人： Nancy Stagliano , Aileen Healy , Susan Acton , Katherine Galvin , Mary Donoghue , Amelie Rodrigue-Way , James Tomlinson
CPC分类号： C07K14/47
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
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公开(公告)号：US08541203B2
公开(公告)日：2013-09-24
申请号：US13411416
申请日：2012-03-02
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
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公开(公告)号：US08529898B2
公开(公告)日：2013-09-10
申请号：US13413447
申请日：2012-03-06
申请人： Patrick Sean Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
发明人： Patrick Sean Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
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公开(公告)号：US20080302732A1
公开(公告)日：2008-12-11
申请号：US12126670
申请日：2008-05-23
CPC分类号： B03C1/015 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B03C1/286 , B03C1/288 , B03C5/028 , B03C2201/18 , B03C2201/26
摘要： A fluidic device employs one or more sorting stations for separating target species from other species in a sample. At least one of the sorting stations employs a magnetic field gradient to accomplish separation. In addition, the sorting station is integrated on a single substrate with one or more other modules for processing the sample. For example, the fluidic device may include both a sorting station and a separate trapping station that holds some or all components of the sample for additional processing. The trapping station may be located at a position upstream or downstream from the sorting module.
摘要翻译： 流体装置采用一个或多个分选站，用于将样品中的目标物种与其他物种分离。 至少一个分选站采用磁场梯度来实现分离。 此外，分选站集成在具有用于处理样品的一个或多个其他模块的单个基板上。 例如，流体装置可以包括分选站和分离收集站，分离站收集样品的一些或所有组分以用于附加处理。 捕集站可以位于分拣模块上游或下游的位置。
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公开(公告)号：US20120244154A1
公开(公告)日：2012-09-27
申请号：US13411409
申请日：2012-03-02
申请人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
发明人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
IPC分类号： C07K19/00 , C12P21/02 , C12N15/63 , A61K39/395 , C12N15/62
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
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6.发明申请ACTIVATABLE BINDING POLYPEPTIDES AND METHODS OF IDENTIFICATION AND USE THEREOF 审中-公开可激活的结合聚合物及其鉴定和使用方法公开(公告)号：US20090304719A1
公开(公告)日：2009-12-10
申请号：US12196269
申请日：2008-08-21
申请人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
发明人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
IPC分类号： A61K39/395 , C07K2/00 , C07K14/00 , C40B30/04 , C40B40/10 , C40B40/02 , C12N15/11 , C40B50/06 , A61K38/16 , C12P21/06 , G01N33/53 , C07K16/00 , A61K49/00 , C12N9/68 , C12N9/50
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
摘要翻译： 本公开提供了可激活的结合多肽（ABP），其包含靶结合部分（TBM），掩蔽部分（MM）和可切割部分（CM）。 本公开提供可激活的抗体组合物，其含有含有抗原结合结构域（ABD），MM和CM的TBM。 此外，本公开还提供了包含第一TBM，第二TBM和CM的ABP。 ABP表现出“可激活”构象，使得当不能切割CM时，在存在能够切割CM的切割剂的情况下，TBM中的至少一种在未切割时难以接触。 本公开进一步提供候选ABP的文库，筛选鉴定这种ABP的方法和使用方法。 本公开进一步提供了具有结合VEGF，CTLA-4或VCAM，具有结合VEGF的第一TBM的ABP和结合FGF的第二TBM的TBM以及组合物和使用方法的ABP。
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7.发明授权Activatable binding polypeptides and methods of identification and use thereof 有权可活化的结合多肽及其鉴定和使用的方法公开(公告)号：US08518404B2
公开(公告)日：2013-08-27
申请号：US13411409
申请日：2012-03-02
申请人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
发明人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , C07K16/46
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
摘要翻译： 提供了含有靶结合部分（TBM），掩蔽部分（MM）和可切割部分（CM）的可活化结合多肽（ABPs）。 提供含有含有抗原结合结构域（ABD），MM和CM的TBM的可活化抗体组合物。 此外，提供了包含第一TBM，第二TBM和CM的ABP。 ABP表现出“可激活”构象，使得当不能切割CM时，在存在能够切割CM的切割剂的情况下，TBM中的至少一种在未切割时难以接触。 还提供了候选ABP的图书馆，筛选鉴定这种ABP的方法和使用方法。 还提供了具有结合VEGF，CTLA-4或VCAM的TBM的ABP，具有结合VEGF的第一TBM的ABP和结合FGF的第二TBM，以及组合物和使用方法。
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公开(公告)号：US20120237977A1
公开(公告)日：2012-09-20
申请号：US13411416
申请日：2012-03-02
申请人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
发明人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare
CPC分类号： C07K16/22 , C07K16/24 , C07K16/2818 , C07K16/2836 , C07K16/42 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/50 , C12N15/1034 , C12N15/1044
摘要： Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
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