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公开(公告)号：US20230293651A1
公开(公告)日：2023-09-21
申请号：US18321635
申请日：2023-05-22
申请人： Nantomics LLC
CPC分类号： A61K39/0011 , G01N33/57484 , G16H20/00 , G16H20/40 , G16H70/60 , G16B20/20 , G16B30/10 , G16B20/00
摘要： Contemplated cancer treatments comprise recursive analysis of patient-, cancer-, and location-specific neoepitopes from various biopsy sites of a patient after treatment or between successive rounds of immunotherapy and/or chemotherapy to inform further immunotherapy. Recursive analysis preferably includes various neoepitope attributes to so identify treatment relevant neoepitopes.
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公开(公告)号：US11623001B2
公开(公告)日：2023-04-11
申请号：US15292095
申请日：2016-10-12
申请人： NantOmics, LLC
发明人： Patrick Soon-Shiong , Stephen Charles Benz , Andrew Nguyen , Shahrooz Rabizadeh , Kayvan Niazi , Oleksandr Buzko , Jay Gardner Nelson
摘要： Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first identified in a patient- and cancer-specific manner and then further filtered by HLA-match to the patient. Selected neoepitopes are then expression using sequence elements that direct the expressed neoepitope to the HLA-type (MHC-I and/or MHC-II subtype) that has desirable affinity to the filtered neoepitope.
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公开(公告)号：US11504420B2
公开(公告)日：2022-11-22
申请号：US16571008
申请日：2019-09-13
申请人： NANTOMICS, LLC
IPC分类号： A61K39/00 , C12N5/09 , C07K16/30 , G01N33/574 , C07K16/22 , C07K14/47 , A61K47/68 , C12N5/0783
摘要： Certain universal neoepitopes and cancer specific neoepitopes and methods therefore are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.
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公开(公告)号：US20190287656A1
公开(公告)日：2019-09-19
申请号：US16422568
申请日：2019-05-24
申请人： Nantomics, LLC
摘要： Contemplated antiviral/cancer treatments comprise analysis of neoepitopes from viral DNA that has integrated into the host genome, and design of immunotherapeutic agents against such neoepitopes.
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公开(公告)号：US20190099475A1
公开(公告)日：2019-04-04
申请号：US15565203
申请日：2016-04-08
申请人： NANTOMICS, LLC
IPC分类号： A61K39/00 , C12N5/0783
摘要： Certain universal neoepitopes and cancer specific neoepitopes and methods therefor are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.
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公开(公告)号：US20230210969A1
公开(公告)日：2023-07-06
申请号：US17938270
申请日：2022-10-05
申请人： Nantomics LLC
IPC分类号： A61K39/00 , A61K47/68 , C07K14/47 , C12N5/0783 , G01N33/574 , C07K16/30 , C12N5/09 , C07K16/22
CPC分类号： A61K39/001102 , A61K47/6851 , C07K14/4702 , C12N5/0638 , C12N5/0646 , A61K39/001144 , G01N33/57407 , C07K16/30 , C12N5/0693 , C07K16/22 , A61K2039/812 , A61K2039/53 , A61K2039/505 , A61K2039/80 , C07K2319/60 , A61K2039/892 , C07K2317/34 , C07K2319/55
摘要： Certain universal neoepitopes and cancer specific neoepitopes and methods therefor are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.
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公开(公告)号：US10339274B2
公开(公告)日：2019-07-02
申请号：US15291516
申请日：2016-10-12
申请人： NantOmics, LLC
摘要： Contemplated antiviral/cancer treatments comprise analysis of neoepitopes from viral DNA that has integrated into the host genome, and design of immunotherapeutic agents against such neoepitopes.
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公开(公告)号：US20170028044A1
公开(公告)日：2017-02-02
申请号：US15292095
申请日：2016-10-12
申请人： NantOmics, LLC
发明人： Patrick Soon-Shiong , Stephen Charles Benz , Andrew Nguyen , Shahrooz Rabizadeh , Kayvan Niazi , Oleksandr Buzko , Jay Gardner Nelson
IPC分类号： A61K39/00
CPC分类号： A61K39/0011
摘要： Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first identified in a patient- and cancer-specific manner and then further filtered by HLA-match to the patient. Selected neoepitopes are then expression using sequence elements that direct the expressed neoepitope to the HLA-type (MHC-I and/or MHC-II subtype) that has desirable affinity to the filtered neoepitope.
摘要翻译： 提出了用于制备和使用重组病毒或其它重组表达系统的方法和组合物，其中首先以患者和癌症特异性方式鉴定新表皮，然后通过与患者的HLA匹配进一步过滤。 然后使用将表达的新表皮引导至对经过滤的新表皮具有期望亲和力的HLA型（MHC-1和/或MHC-II亚型）的序列元件进行选择的新表皮。
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公开(公告)号：US20240321392A1
公开(公告)日：2024-09-26
申请号：US18740319
申请日：2024-06-11
申请人： Nantomics LLC
IPC分类号： G16B20/30 , A61K39/00 , C12Q1/70 , G16B35/00 , G16C20/60 , G16H10/40 , G16H20/10 , G16H20/40 , G16H70/60
CPC分类号： G16B20/30 , A61K39/0011 , C12Q1/708 , G16B35/00 , G16C20/60 , G16H10/40 , G16H20/10 , G16H20/40 , G16H70/60 , A61K39/00 , C12Q2600/106 , C12Q2600/156
摘要： Contemplated antiviral/cancer treatments comprise analysis of neoepitopes from viral DNA that has integrated into the host genome, and design of immunotherapeutic agents against such neoepitopes.
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公开(公告)号：US20240079089A1
公开(公告)日：2024-03-07
申请号：US18506554
申请日：2023-11-10
申请人： Nantomics LLC
IPC分类号： G16B25/10 , C12Q1/6827 , C12Q1/6869 , G16B20/00 , G16B20/20 , G16B30/10 , G16B40/00 , G16H50/20 , G16H50/30
CPC分类号： G16B25/10 , C12Q1/6827 , C12Q1/6869 , G16B20/00 , G16B20/20 , G16B30/10 , G16B40/00 , G16H50/20 , G16H50/30 , G01N2570/00 , Y02A90/10
摘要： Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.
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