公开(公告)号：US10913068B2

公开(公告)日：2021-02-09

申请号：US15557957

申请日：2016-03-14

申请人： Nanyang Technological University ,  Agency for Science, Technology And Research ,  The Methodist Hospital

发明人： Joseph Sylvester Chang ,  Geok Soon Lim ,  Lei Zhang ,  Zhiping Wang ,  Ruige Wu ,  Stephen T. C. Wong ,  Kemi Cui

IPC分类号： B01L7/00 ,  C12Q1/686 ,  A61B5/15 ,  A61B5/153 ,  C12Q1/6851

摘要： A testing device is provided. The testing device includes a capturing tool and a microfluidic chip having a plurality of chambers connected in a network, a sample receiving port connected to the network, and a guide structure configured to receive the capturing tool, wherein the capturing tool is configured to capture sample in a distal position from the guide structure and further configured to transfer the captured sample to the sample receiving port in a proximal position from the guide structure.

公开(公告)号：US10765675B2

公开(公告)日：2020-09-08

申请号：US15755258

申请日：2016-08-22

申请人： The Methodist Hospital

发明人： Hong Zhao ,  Stephen T. C. Wong

IPC分类号： A61K31/506 ,  A61P35/00 ,  A61K31/155 ,  A61K45/06 ,  C12Q1/6886

摘要： A method for treating a sarcoma by administering a tyrosine kinase inhibitor and a biguanide compound. Also described is a method for treating a tumor of the Ewing Sarcoma family by obtaining a tumor sample; determining in the sample gene expression levels of ACTB, B2M, MLH1, PRKDC, XPC, APEX1, ERCC5, MMS19, or RAD23; and administering a tyrosine kinase inhibitor and a biguanide compound. Furthermore, a pharmaceutical composition for treating a Ewing family tumor is disclosed. The composition contains a tyrosine kinase inhibitor, a biguanide compound, and a pharmaceutically acceptable excipient.

公开(公告)号：US10314811B2

公开(公告)日：2019-06-11

申请号：US15754133

申请日：2016-08-18

申请人： The Methodist Hospital

发明人： Ren Kong ,  Hong Zhao ,  Stephen T. C. Wong

IPC分类号： A61K9/00 ,  A61P1/12 ,  A61K31/12 ,  A61K45/06 ,  A61K31/121 ,  A61K31/352 ,  A61K31/353 ,  A61K31/4745

摘要： A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Also disclosed is a method for treating cancer by administering a chemotherapy agent together with hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Furthermore, a composition for treating cancer is provided, the composition containing a chemotherapy agent and hesperetin, naringenin, or 2′,4′-dihydroxychalcone.