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公开(公告)号：US20240353405A1
公开(公告)日：2024-10-24
申请号：US18682794
申请日：2022-08-08
发明人： Laura SUTARLIE , Xiaodi SU , Alan Jenting SHE , Khin Moh Moh AUNG
IPC分类号： G01N33/569 , G01N33/543 , G01N35/10
CPC分类号： G01N33/56911 , G01N33/54386 , G01N35/1002 , G01N35/1067 , G01N35/1095
摘要： The disclosure concerns bacterial cell counting devices, systems and methods thereof. The bacterial cell counting device comprises at least one cartridge for containing reagents; an inlet for introducing a sample containing bacterial cells into the device; an optofluidic chip separately in fluid communication with the cartridge and the inlet; a filter strip passing through the optofluidic chip and in fluid communication with the cartridge and the inlet, the filter strip for trapping or retaining bacterial cells on its surface such that the bacterial cells can interact with the reagents as they flow through the filter strip; and a controller for controlling a sequential flow of reagents and sample to the filter strip via the optofluidic chip. The optofluidic chip is capable of detecting a colorimetric and/or fluorescence output emitted from the bacterial cells modified by the reagents in order for the bacterial cells to be quantified relative to a control.
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2.发明公开公开(公告)号：US20240353339A1
公开(公告)日：2024-10-24
申请号：US18683345
申请日：2022-08-19
IPC分类号： G01N21/65 , G01N33/543 , G01N33/68
CPC分类号： G01N21/658 , G01N33/54346 , G01N33/54373 , G01N33/6893 , G01N2333/525 , G01N2333/54 , G01N2333/96419
摘要： A biocompatible SERS-active polymer membrane configured to detect biomarkers in a sample. The biocompatible SERS-active polymer membrane includes a flexible and porous polymer membrane and SERS-active nanoparticles formed on the flexible and porous polymer membrane, where the flexible and porous polymer membrane includes cellulose or an elastomeric polymer. Also disclosed herein is a method of forming the biocompatible SERS-active polymer membrane and a method of determining a state of wound healing in a diabetic individual involving the use of the biocompatible SERS-active polymer membrane.
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公开(公告)号：US20240344135A1
公开(公告)日：2024-10-17
申请号：US18294652
申请日：2022-08-05
IPC分类号： C12Q1/6886 , C12Q1/6806
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： There is provided a method of detecting and/or determining the presence of one or more thyroid-specific nucleic acid, the method comprising annealing the one or more thyroid-specific nucleic acid in the presence of a control nucleic acid, and subjecting each of the one or more thyroid-specific nucleic acid to one or more amplification step in the presence of a mixture comprising a surfactant and an oligonucleotide primer and/or probe capable of hybridizing with the one or more thyroid-specific nucleic acid, wherein the oligonucleotide primer and/or probe comprises a cleavage site and a cleavable 3′ end. Also disclosed are methods of detecting and/or determining thyroid cancer recurrence and/or metastasis and thyroid-specific nucleic acid detection mixtures, and kits thereof.
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公开(公告)号：US20240341326A1
公开(公告)日：2024-10-17
申请号：US18682963
申请日：2022-06-29
发明人： Xuezhi Bi
摘要： There is provided a method of removing gossypol from one or more plant parts, comprising incubating a mixture of the one or more plant parts with an acidified amino acid solution, wherein amino acid comprises more than one nitrogen-containing functionality. There is also provided a protein isolate having a total gossypol content of less than 250 ppm.
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公开(公告)号：US20240335589A1
公开(公告)日：2024-10-10
申请号：US18294106
申请日：2022-08-04
发明人： Deepak Choudhury , Jia Sheng Lee , Ahmad Amirul , May Win Naing
IPC分类号： A61L27/36
CPC分类号： A61L27/3633 , A61L27/3683 , A61L2430/40
摘要： The invention relates to a method for decellularization of tissue samples to produce decellularized extracellular matrix (dECM) by performing one or more wash cycles in a reactor using a reagent after at least partially submerging the tissue sample in the reagent, wherein the reactor comprising a tissue chamber in fluid communication with a reactor chamber. The method further comprising the steps of agitating the tissue sample and/or the reagent such that the tissue sample circulates in the reagent while retaining the tissue sample in a tissue chamber or a decellularization reactor, monitoring at least one parameter of the reagent and/or at least one parameter of the tissue sample, and adjusting one or more wash cycles based on said monitoring. The invention further relates to a decellularization reactor and a decellularization system for decellularizing a tissue sample.
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公开(公告)号：US12104168B2
公开(公告)日：2024-10-01
申请号：US17054108
申请日：2019-05-10
发明人： Iwona Szczerbinska , Yun Shen Chan , Huck Hui Ng
CPC分类号： C12N5/0018 , C12N5/0672 , C12N5/0678 , C12N5/068 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/135 , C12N2501/16 , C12N2501/165 , C12N2501/727
摘要： The present invention relates to a cell culture medium for preparing liver, gastric, pancreatic, colon or intestinal adult stem cell isolated from adult tissue, as well as for maintaining such stem cell in the undifferentiated state. The cell culture medium comprises a base medium; an ABL and SRC dual kinase inhibitor/an ABL kinase inhibitor and a SRC kinase inhibitor; a mitogenic factor; a WNT signalling pathway activator; a stimulator for NAD+ and NADP+ generation; and a cAMP/PKA pathway activator. In a particular embodiment, the ABL and SRC dual kinase inhibitor is Dasatinib; the mitogenic factor is EGF; the WNT signalling pathway activator is R-Spondin 1; the stimulator for NAD+ and NADP+ generation is nicotinamide; and the cAMP/PKA pathway activator is cholera endotoxin.
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公开(公告)号：US20240309326A1
公开(公告)日：2024-09-19
申请号：US18577873
申请日：2022-07-08
IPC分类号： C12N5/077
CPC分类号： C12N5/0653 , C12N2500/36 , C12N2500/38 , C12N2501/33 , C12N2501/39 , C12N2531/00
摘要： This technology relates to a method of isolating adipose-derived cell lines from an animal, a method of isolating adipocytes from an animal, and isolated adipose-derived cell lines thereof.
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公开(公告)号：US20240301501A1
公开(公告)日：2024-09-12
申请号：US18281523
申请日：2022-03-11
发明人： Alexander Lezhava , Astrid Irwanto , Kanika Jain , Anar Sanjaykumar Kothary , Jocelyn Tan , Flona Ng , Zhihao Tan
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The invention relates to a method for assessing and evaluating the potential effect of therapeutics on an individual. In particular, the invention uses real-time PCR-based pharmacogenomic assays in assessing such potential effects. In an aspect of the present invention, there is provided a method of assessing or evaluating a subject's likelihood of developing an adverse reaction in response to an administration of a therapeutic agent, or a method of assessing or evaluating a therapeutic agent's efficacy on a subject, the method comprising determining in a single real-time polymerase chain reaction run the presence of a variant in a set of genes consisting of CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 in a sample obtained from the subject, wherein the presence of a variant on any one of the genes in the set of genes is indicative of a risk to an adverse reaction and/or a change in efficacy to the therapeutic agent.
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公开(公告)号：US20240273869A1
公开(公告)日：2024-08-15
申请号：US18569997
申请日：2022-06-30
发明人： Jian Wei Jayce CHENG , Pawan KUMAR , Anas ABUTAHA , Daniil BASH , Tonio BUONASSISI , Kedar HIPPALGAONKAR
CPC分类号： G06V10/764 , G01N35/00732 , G06V10/12 , G06V10/24 , G06V10/28 , G06V10/44 , G06V20/70
摘要： A data collection apparatus (10) and a computer-implemented data collection method (50) using the same are provided. The data collection apparatus (10) includes a first linear stage (12) and a second linear stage (14). A sample carriage (16) is attached to the first linear stage (12), the first linear stage (12) being operable to move the sample carriage (16) along a first axis. A probe carriage (18) is attached to the second linear stage (14), the second linear stage (14) being operable to move the probe carriage (18) along a second axis. A third linear stage (20) is attached to the probe carriage (18). In use, the third linear stage (20) is operable to receive a detachable characterisation probe (22) and to move the characterisation probe (22) along a third axis. A camera (24) is attached to the probe carriage (18). In use, the camera (24) is configured to capture an image of one or more samples on the sample carriage (16).
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公开(公告)号：US12059431B2
公开(公告)日：2024-08-13
申请号：US17659183
申请日：2022-04-14
发明人： James L. Hedrick , Yi Yan Yang , Nathaniel H. Park , Jiayu Leong , Chuan Yang , Xin Ding , Yiran Zhen , Cherylette Anne Alexander , Jye Yng Teo
IPC分类号： A61K31/785
CPC分类号： A61K31/785
摘要： Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.
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