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公开(公告)号：US20070299014A1
公开(公告)日：2007-12-27
申请号：US10565497
申请日：2004-07-30
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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2.发明申请Biogically non-degradable peptides, angiostensin converting enzyme inhibitor, drug and functional food 审中-公开生物不可降解肽，血管紧张素转换酶抑制剂，药物和功能性食物公开(公告)号：US20070122451A1
公开(公告)日：2007-05-31
申请号：US10566057
申请日：2004-07-30
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention provides novel in vivo indigestible peptides that are highly absorbable and hardly digestible in living organism when administered orally or through other route, and expected to effectively exhibit functions, such as hypotensive effect, in living organism, and ACE inhibitors prepared with the peptides, and medicine or functional food expected to effectively exhibit hypotensive effect in living organism. The in vivo indigestible peptides are dipeptides or tripeptides having Pro at the carboxyl terminals, selected from the group consisting of Ile-Pro, Glu-Pro, Arg-Pro, Gln-Pro, Met-Pro, and Ser-Pro-Pro.
摘要翻译： 本发明提供新的体内难消化的肽，其在口服或通过其它途径施用时在活生物体中是高度可吸收的且几乎不可消化的，并且预期在活体中有效表现出降血压作用等功能，并且用肽制备的ACE抑制剂 ，以及预期在活体中有效显示降血压作用的药物或功能食品。 体内难消化的肽是在羧基末端具有Pro的二肽或三肽，其选自Ile-Pro，Glu-Pro，Arg-Pro，Gln-Pro，Met-Pro和Ser-Pro-Pro。
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公开(公告)号：US20110082281A1
公开(公告)日：2011-04-07
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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公开(公告)号：US06293198B1
公开(公告)日：2001-09-25
申请号：US09687302
申请日：2000-10-13
申请人： Seiichi Mizuno
发明人： Seiichi Mizuno
IPC分类号： B41L4760
CPC分类号： B41F7/24 , B41F35/00 , B41P2235/31
摘要： In a circulation treatment system and method for treating a fountain solution the amounts of BOD, COD, n-hexane and SS are reduced in the fountain solution to recycle the fountain solution without draining it off. Circulation passages are connected to a vessel of a dampening section of an offset rotary press via communication passages, and circulate a fountain solution by introducing the fountain solution in the vessel from an introducing port and discharging the fountain solution from a discharging port. In the course of the circulation passages is a line pump for forcibly circulating the fountain solution, a potential absorption filtering device using an absorbing effect of a zeta potential, and an activated carbon filtering device using an absorbing effect of activated carbon. Fine particles of ink, paper, oil or similar materials contained in the fountain solution are first absorbed and removed by the potential absorption filtering device and then the fountain solution is decolorized and deodorized by the activated carbon filtering device.
摘要翻译： 在循环处理系统和润版液处理方法中，润版液中的BOD，COD，正己烷和SS的量减少，以循环润版液而不排出。 循环通道通过连通通道连接到偏置旋转压力机的阻尼部分的容器，并且通过从引入口将润版液引入容器中并从排出口排出润版液，来循环润版液。 在循环过程中，用于强制循环润版液的线路泵，使用ζ电位的吸收效果的潜在吸收过滤装置，以及使用活性炭的吸收效果的活性炭过滤装置。 首先通过潜在的吸收过滤装置吸收和除去润版液中所含的油墨，纸，油或类似物质的细颗粒，然后通过活性炭过滤装置对润版液进行脱色和除臭。
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