公开(公告)号：US20140113311A1

公开(公告)日：2014-04-24

申请号：US14123899

申请日：2012-06-04

申请人： Naoyuki Yamamoto ,  Tsutomu Masuda

发明人： Naoyuki Yamamoto ,  Tsutomu Masuda

IPC分类号： G01N33/53

CPC分类号： G01N33/5306 ,  C08F220/36 ,  C08F220/60 ,  G01N33/542

摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

摘要翻译： 本发明的目的是提供一种与常规免疫凝集增强剂相比具有优异的凝集增强作用的凝集增强剂，本发明涉及用于免疫凝集测定方法的凝集增强剂，其包含具有单体单元 以下通式[1]表示：（其中R1表示氢原子或甲基; R2和R3分别独立地表示甲基或乙基; X表示-NH-或氧原子; n表示1的整数） 至6; m表示1〜3的整数），以及免​​疫凝集测定方法，其中在上述用于免疫凝集测定法的凝集增强剂的共存下，将分析物的抗体或分析物的抗原进入 与分析物接触以引起抗原 - 抗体反应。

公开(公告)号：US20120328338A1

公开(公告)日：2012-12-27

申请号：US13479609

申请日：2012-05-24

申请人： Masahiro Nawa ,  Kazuaki Aoki ,  Shouhei Takeda ,  Yasuo Nami ,  Naoyuki Yamamoto ,  Koji Takematsu

发明人： Masahiro Nawa ,  Kazuaki Aoki ,  Shouhei Takeda ,  Yasuo Nami ,  Naoyuki Yamamoto ,  Koji Takematsu

IPC分类号： G03G15/20

CPC分类号： G03G15/2053

摘要： An image heating apparatus includes a roller, a heating portion disposed within the roller, a bearing portion fitted around an end portion of the roller to rotably support the roller, and a retaining ring attached at an axially predetermined position of the roller to restrict the roller from moving in a axial direction of the roller with respect to the bearing portion. The retaining ring includes first and second projections fitted into a hole portion of the roller. Profiles of side surfaces of these first and second projections abutting edges of the hole portion in a circumferential direction are recessed in the circumferential direction.

摘要翻译： 图像加热装置包括辊，设置在辊内的加热部分，围绕辊的端部安装以可旋转地支撑辊的轴承部分，以及附接在辊的轴向预定位置以限制辊的保持环 从而相对于轴承部分在辊的轴向移动。 保持环包括装配到辊的孔部分中的第一和第二突起。 这些第一和第二突出部的圆周方向上的孔部的邻接边缘的轮廓在圆周方向上凹陷。

公开(公告)号：US20120115786A1

公开(公告)日：2012-05-10

申请号：US13292561

申请日：2011-11-09

申请人： Mari TAKAHASHI ,  Naoyuki Yamamoto ,  Kazuhisa Yamada ,  Toshirou Iketani

发明人： Mari TAKAHASHI ,  Naoyuki Yamamoto ,  Kazuhisa Yamada ,  Toshirou Iketani

IPC分类号： A61K38/06 ,  A61P9/00

CPC分类号： A61K38/018 ,  A61K38/06

摘要： An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein. Reduction of risk may be expected in onset, particularly likely in the morning, of various diseases caused by risk of circadian variation of blood pressure, such as cerebral infarction, myocardial infarction,myocardialischemia, atherosclerosis, cardiac failure, cerebral stroke, coronary artery diseases, and peripheral vascular diseases.

摘要翻译： 本发明提供一种减轻由于血压异常昼夜节律引起的疾病发病风险的药剂。 该药物能够在夜间至清晨有效降低血压非溺水昼夜状况的个体，特别是其中正常的SBP和DBP的正常个体，因此能够降低起病风险，特别可能 早晨，由血压昼夜变化引起的疾病。 该试剂用于给予这些受试者，并含有含有Val-Pro-Pro和Ile-Pro-Pro并通过动物乳蛋白水解获得的水解产物或其浓缩物。 可能预期，由于血压昼夜变化风险，如脑梗死，心肌梗塞，心肌缺血，动脉粥样硬化，心力衰竭，脑卒中，冠状动脉疾病等引起的各种疾病，特别是早晨发病风险的降低， 和外周血管疾病。

公开(公告)号：US08105770B2

公开(公告)日：2012-01-31

申请号：US12524267

申请日：2008-01-28

申请人： Makoto Amano ,  Naoyuki Yamamoto

发明人： Makoto Amano ,  Naoyuki Yamamoto

IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N33/00 ,  B01L3/00 ,  C07H21/00 ,  C07H21/02

CPC分类号： C12Q1/6816 ,  Y10T436/143333 ,  C12Q2565/501 ,  C12Q2563/107 ,  C12Q2545/107

摘要： [PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity.[MEANS FOR SOLVING PROBLEMS] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-origin genomic DNA fragment to be tested with either a label represented by the following general formula (1) or another label represented by the general formula (2), and labeling a control genomic fragment that serves as a standard for detecting a difference from the test genomic DNA fragment with the other label; (b) hybridizing the labeled test genomic DNA fragment and the labeled control genomic DNA fragment each with a specimen nucleic acid containing a nucleic acid sequence for detecting the difference between the test genomic fragment and the control genomic fragment; and (c) detecting an amplification or deletion in the test genomic DNA fragment by using the fluorescent intensities thus obtained as an indication; and a kit for the above-described method which contains a nucleotide residue labeled with the label represented by the following general formula (1) and a nucleotide residue labeled with the label represented by the following general formula (2).

摘要翻译： [问题]提供CGH方法，特别是CGH微阵列方法，使得能够以高精度和灵敏度提高检测。 用于解决问题的手段一种方法，其包括：（a）用作为待测试的细胞来源的基因组DNA片段的测试基因组DNA片段用以下通式（1）表示的标记或由 通式（2），并标记用作检测来自测试基因组DNA片段与另一个标签的差异的标准的对照基因组片段; （b）将标记的测试基因组DNA片段和标记的对照基因组DNA片段与含有用于检测测试基因组片段和对照基因组片段之间的差异的核酸序列的标本核酸杂交; 和（c）通过使用由此获得的荧光强度作为指示来检测测试基因组DNA片段中的扩增或缺失; 以及上述方法的试剂盒，其含有用下述通式（1）表示的标记标记的核苷酸残基和用下述通式（2）表示的标记标记的核苷酸残基。

公开(公告)号：US20110286767A1

公开(公告)日：2011-11-24

申请号：US13194244

申请日：2011-07-29

申请人： Masanobu NAKAJIMA ,  Takahiro NAKASE ,  Naoyuki YAMAMOTO

发明人： Masanobu NAKAJIMA ,  Takahiro NAKASE ,  Naoyuki YAMAMOTO

IPC分类号： G03G15/02

CPC分类号： G03G15/0291 ,  G03G15/751 ,  G03G2215/027

摘要： An image forming apparatus is constituted by an image bearing member; a corona charging member including a wire; a heat generating member for generating heat by energization; a shielding member, including the heat generating member, capable of shielding a portion of the corona charging member opposing to the image bearing member from the image bearing member by being moved between the corona charging member and the image bearing member; an energization control member for controlling energization of the heat generating member; and moving member for moving the shielding member to a first position at which the shielding member shields the portion and a second position retracted from the first position. When the shielding member is located at the first position, at least a part of the heat generating member is disposed between the corona charging member and the image bearing member.

摘要翻译： 图像形成装置由图像承载部件构成; 包括线的电晕充电部件; 通过通电产生热量的发热部件; 包括所述发热元件的屏蔽部件能够通过在所述电晕充电部件和所述图像承载部件之间移动而将与所述图像承载部件相对的所述电晕充电部件的一部分从所述图像承载部件屏蔽起来; 通电控制部件，用于控制发热部件的通电; 以及用于将屏蔽构件移动到屏蔽构件遮蔽该部分的第一位置和从第一位置缩回的第二位置的移动构件。 当屏蔽构件位于第一位置时，发热构件的至少一部分设置在电晕充电构件和图像承载构件之间。

公开(公告)号：US08020486B2

公开(公告)日：2011-09-20

申请号：US12154457

申请日：2008-05-22

申请人： Naoyuki Yamamoto ,  Ryouhei Yamamoto

发明人： Naoyuki Yamamoto ,  Ryouhei Yamamoto

IPC分类号： H05K7/00 ,  A61G7/00

CPC分类号： F15B11/042 ,  F15B11/044 ,  F15B15/204 ,  F15B2211/212 ,  F15B2211/40515 ,  F15B2211/455 ,  F15B2211/46 ,  F15B2211/7052 ,  F15B2211/7114

摘要： The objective of the present invention is to provide a device that accurately communicates a subtle variation of an operation side to an action side. Specifically, in the present invention, an operating device is provided to perform a lock release operation of an extension device. The operating device feeds oil to a valve chamber by pressing a piston. When the flow rate of the fed oil is excessive, the valve is pressed to an opening resisting a biasing force of a compressed spring, thereby a rapid increase in the oil supplied to the action section is suppressed. Further, the supplied oil is suppressed to a very small amount by the throttle section, thereby an increase in the operation amount on the action section side is suppressed while maintaining the supply of the oil.

摘要翻译： 本发明的目的是提供一种将操作侧的细微变化精确地传递到动作侧的装置。 具体地，在本发明中，提供了一种操作装置，用于执行扩展装置的锁定解除操作。 操作装置通过按压活塞将油馈送到阀室。 当供给油的流量过大时，将阀按压到抵抗压缩弹簧的作用力的开口，从而抑制供给到动作部的油的快速增加。 此外，通过节流部将所供给的油抑制得非常小，从而在保持供油的同时抑制作用部侧的操作量的增加。

公开(公告)号：US08003092B2

公开(公告)日：2011-08-23

申请号：US12253819

申请日：2008-10-17

申请人： Naoyuki Yamamoto ,  Yuu Ishida ,  Izuki Bando

发明人： Naoyuki Yamamoto ,  Yuu Ishida ,  Izuki Bando

IPC分类号： A01N63/00 ,  C12N1/20

CPC分类号： A61K35/747 ,  Y10S435/854

摘要： The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.

摘要翻译： 本发明提供一种抗过敏剂，其含有选自嗜酸乳酸杆菌乳酸菌，发酵乳杆菌及其组合的乳酸菌作为活性成分。 抗过敏剂能够通过降低IgE水平来改善过敏反应，这有助于I型过敏的发生，并且易于服用和高度安全。 本发明还提供抗过敏剂用于降低过敏的用途，以及使用抗过敏剂降低过敏的方法。

公开(公告)号：US20110091225A1

公开(公告)日：2011-04-21

申请号：US12908509

申请日：2010-10-20

申请人： Naoyuki Yamamoto

发明人： Naoyuki Yamamoto

IPC分类号： G03G15/20

CPC分类号： G03G15/2007 ,  G03G15/2039

摘要： An image heating apparatus includes a coil; a rotatable image heating member for generating heat by a magnetic flux generated by the coil to heat an image on a recording material; a voltage source for applying a high frequency current to the coil; a temperature detecting member for detecting a temperature of the image heating member; control device for controlling electric power supply to the coil from the voltage source on the basis of an output of the temperature detecting member such that the temperature of the image heating member is maintained at a set temperature T; and protecting device for stopping the electric power supply to the coil when the output of the temperature detecting member indicates a predetermined abnormal temperature Te, wherein at least a part of the image heating member is made of a magnetism-adjusted alloy having a predetermined magnetic permeability decrease start temperature Tc′ and a predetermined Curie temperature, and wherein T≦Tc′

摘要翻译： 图像加热装置包括线圈; 可旋转图像加热构件，用于通过由线圈产生的磁通量来产生热量以加热记录材料上的图像; 用于向线圈施加高频电流的电压源; 温度检测部件，用于检测图像加热部件的温度; 控制装置，用于基于温度检测部件的输出控制从电压源向线圈的电力供应，使得图像加热部件的温度保持在设定温度T; 以及保护装置，用于当温度检测部件的输出表示预定的异常温度Te时停止对线圈的电力供应，其中图像加热部件的至少一部分由具有预定磁导率的磁调节合金制成 降低起始温度Tc'和预定居里温度，并且其中T＆lt; lE; Tc'

公开(公告)号：US20100112711A1

公开(公告)日：2010-05-06

申请号：US12524267

申请日：2008-01-28

申请人： Makoto Amano ,  Naoyuki Yamamoto

发明人： Makoto Amano ,  Naoyuki Yamamoto

IPC分类号： G01N33/53 ,  C07H21/00

CPC分类号： C12Q1/6816 ,  Y10T436/143333 ,  C12Q2565/501 ,  C12Q2563/107 ,  C12Q2545/107

摘要： [Problems] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity.[Means for Solving Problems] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-origin genomic DNA fragment to be tested with either a label represented by the following general formula (1) or another label represented by the general formula (2), and labeling a control genomic fragment that serves as a standard for detecting a difference from the test genomic DNA fragment with the other label; (b) hybridizing the labeled test genomic DNA fragment and the labeled control genomic DNA fragment each with a specimen nucleic acid containing a nucleic acid sequence for detecting the difference between the test genomic fragment and the control genomic fragment; and (c) detecting an amplification or deletion in the test genomic DNA fragment by using the fluorescent intensities thus obtained as an indication; and a kit for the above-described method which contains a nucleotide residue labeled with the label represented by the following general formula (1) and a nucleotide residue labeled with the label represented by the following general formula (2).

摘要翻译： [问题]提供CGH方法，特别是CGH微阵列方法，使得能够以提高的精度和灵敏度提高检测。 [解决问题的方法]一种方法，其包括：（a）使用以下通式（1）表示的标记或以下述通式（1）表示的另一标记，将作为待测试的细胞来源基因组DNA片段的检测基因组DNA片段标记为 通式（2），并标记用作检测来自测试基因组DNA片段与另一个标签的差异的标准的对照基因组片段; （b）将标记的测试基因组DNA片段和标记的对照基因组DNA片段与含有用于检测测试基因组片段和对照基因组片段之间的差异的核酸序列的标本核酸杂交; 和（c）通过使用由此获得的荧光强度作为指示来检测测试基因组DNA片段中的扩增或缺失; 以及上述方法的试剂盒，其含有用下述通式（1）表示的标记标记的核苷酸残基和用下述通式（2）表示的标记标记的核苷酸残基。

公开(公告)号：US20090215097A1

公开(公告)日：2009-08-27

申请号：US11988475

申请日：2006-03-14

申请人： Tomokazu Itai ,  Kiyoko Mori ,  Yo Yagura ,  Isao Koyama ,  Naoyuki Yamamoto

发明人： Tomokazu Itai ,  Kiyoko Mori ,  Yo Yagura ,  Isao Koyama ,  Naoyuki Yamamoto

IPC分类号： C12Q1/60 ,  C08G69/08 ,  C08G63/00 ,  C08G63/66 ,  G01N33/92

CPC分类号： G01N33/92 ,  C08F210/00 ,  C08F293/00 ,  C08F293/005 ,  G01N2800/044

摘要： It is an object of the present invention to provide the method for determining cholesterol in lipoprotein and reagent for determining cholesterol comprising the polymer, and the present invention relates to the reagent for determining cholesterol in lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) and the determination method using the polymer comprising the following units as constituents:(iv) a polyethylene glycol segment represented by the general formula [1]: —(CH2CH2O)k—  [1] (wherein, k represents an integer of 10 to 250); (v) a monomer unit represented by the general formula [2]: (wherein R1 represents a hydrogen atom or C1-C3 alkyl group); and (vi) a monomer unit represented by the general formula [3]: [wherein, R2 represents a hydrogen atom or C1-C3 alkyl group, and R3 represents a group represented by the general formula [4]: —COOR4  [4] (wherein, R4 represents an alkyl group, a haloalkyl group or a bornyl group), an alkyl group, an alkoxy group, an aralkyl group or an alkylcarbamoyl group; particularly, in the direct measurement of cholesterols such as HDL, LDL and VLDL contained in the sample, the reagent for determining cholesterol in the presence of said polymer, and the method for determining the concentration of cholesterol in a specific lipoprotein using said reagent for determining cholesterol, and a novel polymer.

摘要翻译： 本发明的目的是提供用于测定脂蛋白胆固醇的方法和用于测定包含聚合物的胆固醇的试剂，本发明涉及用于测定脂蛋白中胆固醇的试剂，例如高密度脂蛋白（HDL），低密度脂蛋白 密度脂蛋白（LDL）和非常低密度脂蛋白（VLDL）的方法，使用包含以下单元的聚合物作为成分的测定方法：（iv）由通式[1]表示的聚乙二醇片段： - formulae description =“In-line Formulas”end =“lead”？> - （CH2CH2O）k- [1] <？in-line-formula description =“In-line formula”end =“tail”？>（其中 ，k表示10〜250的整数）; （v）由通式[2]表示的单体单元：（其中R 1表示氢原子或C 1 -C 3烷基）; 和（vi）由通式[3]表示的单体单元：[其中，R 2表示氢原子或C 1 -C 3烷基，R 3表示由通式[4]表示的基团： -formulae description =“In-line Formulas”end =“lead”？> - COOR4 [4] <？in-line-formula description =“In-line Formulas”end =“tail”？>（其中，R4表示 烷基，卤代烷基或冰片基），烷基，烷氧基，芳烷基或烷基氨基甲酰基; 特别是直接测定样品中含有的HDL，LDL，VLDL等胆固醇的方法，在所述聚合物存在下测定胆固醇的试剂，以及使用上述试剂测定特定脂蛋白中的胆固醇浓度的方法 胆固醇和新型聚合物。