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公开(公告)号：US20070299014A1
公开(公告)日：2007-12-27
申请号：US10565497
申请日：2004-07-30
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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公开(公告)号：US20110082281A1
公开(公告)日：2011-04-07
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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公开(公告)号：US08580557B2
公开(公告)日：2013-11-12
申请号：US12873500
申请日：2010-09-01
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda , Hideo Nishimura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Takanobu Gotou , Keiichi Matsuura , Tadashi Shinoda
IPC分类号： C12N1/00 , C12N9/62 , A61K38/00 , A61K38/05 , A61K38/06 , C12N9/50 , C12N9/48 , A61K47/00 , A61K38/55 , A23C9/12 , C12P21/06 , A61P9/12
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect.
摘要翻译： 本发明涉及含有游离氨基酸的酪蛋白水解物和体内消化不良的肽，其具有最低限度的体内酶消化率，预期在活生物体中表达功能降低作用，以及制备这种水解产物的方法， 及其用途。 本发明的酪蛋白水解物含有游离氨基酸和肽，例如通过水解动物乳酪蛋白得到的体内难消化的肽，包括Xaa-Pro和Xaa-Pro-Pro，其平均链长度不超过2.1 的氨基酸残基数，并具有ACE抑制活性或降血压作用。
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4.发明申请Biogically non-degradable peptides, angiostensin converting enzyme inhibitor, drug and functional food 审中-公开生物不可降解肽，血管紧张素转换酶抑制剂，药物和功能性食物公开(公告)号：US20070122451A1
公开(公告)日：2007-05-31
申请号：US10566057
申请日：2004-07-30
申请人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura
发明人： Naoyuki Yamamoto , Seiichi Mizuno , Shingo Nishimura , Hideo Nishimura , Takanobu Gotou , Keiichi Matsuura
CPC分类号： C07K5/06104 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/06095 , C07K5/081
摘要： The present invention provides novel in vivo indigestible peptides that are highly absorbable and hardly digestible in living organism when administered orally or through other route, and expected to effectively exhibit functions, such as hypotensive effect, in living organism, and ACE inhibitors prepared with the peptides, and medicine or functional food expected to effectively exhibit hypotensive effect in living organism. The in vivo indigestible peptides are dipeptides or tripeptides having Pro at the carboxyl terminals, selected from the group consisting of Ile-Pro, Glu-Pro, Arg-Pro, Gln-Pro, Met-Pro, and Ser-Pro-Pro.
摘要翻译： 本发明提供新的体内难消化的肽，其在口服或通过其它途径施用时在活生物体中是高度可吸收的且几乎不可消化的，并且预期在活体中有效表现出降血压作用等功能，并且用肽制备的ACE抑制剂 ，以及预期在活体中有效显示降血压作用的药物或功能食品。 体内难消化的肽是在羧基末端具有Pro的二肽或三肽，其选自Ile-Pro，Glu-Pro，Arg-Pro，Gln-Pro，Met-Pro和Ser-Pro-Pro。
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