公开(公告)号：US08779119B2

公开(公告)日：2014-07-15

申请号：US12521524

申请日：2007-12-26

申请人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Ippei Yamaoka

发明人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Ippei Yamaoka

IPC分类号： C08B5/14 ,  C08B11/10 ,  C08B11/12

CPC分类号： A61K31/717 ,  C08B5/00 ,  C08B11/12 ,  C08B15/005

摘要： The invention provides a metal salt of a crosslinked cellulose derivative represented by the following formula (I), wherein the degree of substitution of the hydroxyl group of glucose unit of the crosslinked cellulose derivative by a functional group a is 1 or more. R—O—A  (I) {In the formula (I), R represents a crosslinked cellulose residue and A represents a functional group a having cation-exchange ability.}

摘要翻译： 本发明提供由下式（I）表示的交联纤维素衍生物的金属盐，其中交联的纤维素衍生物的官能团a的葡萄糖单元的羟基的取代度为1以上。 R-O-A（I）{式（I）中，R表示交联纤维素残基，A表示具有阳离子交换能力的官能团。

公开(公告)号：US20100324280A1

公开(公告)日：2010-12-23

申请号：US12521525

申请日：2007-12-26

申请人： Ippei Yamaoka ,  Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki

发明人： Ippei Yamaoka ,  Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki

IPC分类号： C07H15/04

CPC分类号： A61K31/717 ,  C08B5/14 ,  C08B11/10 ,  C08B15/005 ,  C08L1/16 ,  C08L1/284

摘要： The present invention provides a sodium absorption inhibitor, a potassium absorption inhibitor, and a phosphorus absorption inhibitor, and a preventive agent, a therapeutic agent and a food for diseases caused by overconsumption of common salt, potassium and phosphorus or diseases which require restriction of ingestion of common salt, potassium and phosphorus to actively and safely excrete overconsumed common salt, potassium and phosphorus excreted outside the body. R—O-A   (I) {In the formula (I), R represents a crosslinked cellulose residue and A represents a functional group a having cation-exchange ability.}

摘要翻译： 本发明提供了一种钠吸收抑制剂，钾吸收抑制剂和磷吸收抑制剂，以及预防药物，治疗剂和由食盐过多，钾和磷引起的疾病或需要限制摄取的疾病的食物。 的普通盐，钾和磷，以积极和安全地排泄体外过量消耗的普通盐，钾和磷。 R-O-A（I）{式（I）中，R表示交联纤维素残基，A表示具有阳离子交换能力的官能团。

公开(公告)号：US20100317844A1

公开(公告)日：2010-12-16

申请号：US12521524

申请日：2007-12-26

申请人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Ippei Yamaoka

发明人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Ippei Yamaoka

IPC分类号： C07H23/00

CPC分类号： A61K31/717 ,  C08B5/00 ,  C08B11/12 ,  C08B15/005

摘要： The invention provides a metal salt of a crosslinked cellulose derivative represented by the following formula (I), wherein the degree of substitution of the hydroxyl group of glucose unit of the crosslinked cellulose derivative by a functional group a is 1 or more. R—O-A  (I) {In the formula (I), R represents a crosslinked cellulose residue and A represents a functional group a having cation-exchange ability.}

摘要翻译： 本发明提供由下式（I）表示的交联纤维素衍生物的金属盐，其中交联的纤维素衍生物的官能团a的葡萄糖单元的羟基的取代度为1以上。 R-O-A（I）{式（I）中，R表示交联纤维素残基，A表示具有阳离子交换能力的官能团。

公开(公告)号：US20050171056A1

公开(公告)日：2005-08-04

申请号：US11097205

申请日：2005-04-04

申请人： Ippei Yamaoka ,  Kyota Sakai ,  Kozo Asagi ,  Takuzi Uesako ,  Kinzi Hashimoto ,  Masaru Kobayashi ,  Tsutomu Uehara

发明人： Ippei Yamaoka ,  Kyota Sakai ,  Kozo Asagi ,  Takuzi Uesako ,  Kinzi Hashimoto ,  Masaru Kobayashi ,  Tsutomu Uehara

IPC分类号： A61K31/717 ,  C08B5/00 ,  C08B5/14 ,  C08B11/00 ,  C08B11/04 ,  C08B11/10 ,  C08B11/12 ,  A61K31/716

CPC分类号： C08B5/00 ,  A61K31/717 ,  C08B5/14 ,  C08B11/00 ,  C08B11/04 ,  C08B11/10 ,  C08B11/12

摘要： The present invention provides a sodium ion absorption inhibitor comprising a metal salt, other than a sodium salt, of a cellulose derivatives represented by the following formula (I) as an active ingredient, whereby absorption of salt excessively present into a living body is effectively inhibited and salt excessively present is excreted outside the body positively and safely. Furthermore, the present invention provides an agent for preventing and treating diseases caused by excessive salt ingestion or diseases in which restriction on salt ingestion is required, comprising the same as an active ingredient, and foods comprising the same. R—O—A   (I) (wherein R represents a cellulose residue and A represents a functional group having cation-exchange ability)

摘要翻译： 本发明提供一种钠离子吸收抑制剂，其包含由下式（I）表示的纤维素衍生物作为活性成分的钠盐以外的金属盐，由此有效抑制过量存在于生物体中的盐的吸收 过量的盐会积极安全地排出体外。 此外，本发明提供了用于预防和治疗由摄取过量引起的疾病或需要对其进行盐摄入限制的疾病的药剂，其包含与活性成分相同的食品以及包含该盐的食品。 <？in-line-formula description =“In-line Formulas”end =“lead”？> ROA（I）<？in-line-formula description =“In-line formula”end =“tail”？> R表示纤维素残基，A表示具有阳离子交换能力的官能团）

公开(公告)号：US06369043B1

公开(公告)日：2002-04-09

申请号：US09582435

申请日：2000-06-26

申请人： Takaya Sato ,  Tutomu Uehara ,  Ippei Yamaoka ,  Kozo Asagi ,  Masaru Kobayashi ,  Hideaki Kohri

发明人： Takaya Sato ,  Tutomu Uehara ,  Ippei Yamaoka ,  Kozo Asagi ,  Masaru Kobayashi ,  Hideaki Kohri

IPC分类号： A01N4304

CPC分类号： C08B37/0042 ,  A61K31/731

摘要： An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal salt (excluding sodium salt) of lambda-carrageenan as an active ingredient, can excrete excessively ingested common salt outside the body positively and safely, and particularly have excellent action in excreting the sodium ions into feces.

摘要翻译： 钠离子吸收抑制剂，钠离子促进剂和用于预防和治疗由过量的常用盐摄入引起的疾病的药剂，其中每一种包含作为活性成分的λ-角叉菜胶的金属盐（不包括钠盐）可以排泄 积极安全地摄取身体以外的普通盐，特别是将钠离子排出到粪便中具有优异的作用。

公开(公告)号：US20100197787A1

公开(公告)日：2010-08-05

申请号：US11992489

申请日：2006-09-29

申请人： Masako Doi ,  Ippei Yamaoka

发明人： Masako Doi ,  Ippei Yamaoka

IPC分类号： A61K31/198 ,  C07C229/08 ,  A61P3/02 ,  A61P3/08 ,  A23L1/29 ,  A23L1/06

CPC分类号： A61K31/198 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/7004 ,  A61K2300/00 ,  A23V2200/328 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2200/322

摘要： Disclosed is a composition for use in the prevention of a hypoglycemic condition, which comprises at least one compound selected from a branched amino acid, a pharmaceutically acceptable salt thereof and a derivative of the amino acid or salt as an active ingredient. The composition can promote the uptake of a saccharide into a brain cell to thereby prevent a hypoglycemic condition.

摘要翻译： 公开了用于预防降血糖病症的组合物，其包含至少一种选自支链氨基酸，其药学上可接受的盐和氨基酸或盐的衍生物作为活性成分的化合物。 该组合物可促进糖摄入脑细胞从而防止低血糖状况。

公开(公告)号：US08273717B2

公开(公告)日：2012-09-25

申请号：US10542660

申请日：2004-02-05

申请人： Ippei Yamaoka ,  Yasuhiro Mitsumoto ,  Masako Doi ,  Tetsuya Fukunaga ,  Mitsuo Nakayama

发明人： Ippei Yamaoka ,  Yasuhiro Mitsumoto ,  Masako Doi ,  Tetsuya Fukunaga ,  Mitsuo Nakayama

IPC分类号： A61K31/7004 ,  A61K31/70 ,  A61K31/195

CPC分类号： A61K31/198

摘要： An inhibitor for perioperative blood sugar elevation characterized by containing a branched amino acid, a compound which can be converted into a branched amino acid in vivo or a compound to which an amino group has been transferred from a branched amino acid. This inhibitor for perioperative blood sugar elevation is useful as a drug which is safe to the living body including human, inhibits abnormal elevation in the blood glucose level caused by anesthesia, surgery, etc., and enables proper blood sugar control, when administered to a perioperative patient.

摘要翻译： 用于围手术期血糖升高的抑制剂，其特征在于含有支链氨基酸，可以在体内转化成支链氨基酸的化合物或从支链氨基酸转移氨基的化合物。 这种围手术期血糖升高抑制剂作为对人体生物有安全的药物有用，抑制由麻醉，手术等引起的血糖水平的异常升高，能够适当地控制血糖 围手术期患者。

公开(公告)号：US20060116426A1

公开(公告)日：2006-06-01

申请号：US10542660

申请日：2004-02-05

申请人： Ippei Yamaoka ,  Yasuhiro Mitsumoto ,  Masako Doi ,  Tetsuya Fukunaga ,  Mitsuo Nakayama

发明人： Ippei Yamaoka ,  Yasuhiro Mitsumoto ,  Masako Doi ,  Tetsuya Fukunaga ,  Mitsuo Nakayama

IPC分类号： A61K31/198

CPC分类号： A61K31/198

摘要： An inhibitor for perioperative blood sugar elevation characterized by containing a branched amino acid, a compound which can be converted into a branched amino acid in vivo or a compound to which an amino group has been transferred from a branched amino acid. This inhibitor for perioperative blood sugar elevation is useful as a drug which is safe to the living body including human, inhibits abnormal elevation in the blood glucose level caused by anesthesia, surgery, etc., and enables proper blood sugar control, when administered to a perioperative patient.

摘要翻译： 用于围手术期血糖升高的抑制剂，其特征在于含有支链氨基酸，可以在体内转化成支链氨基酸的化合物或从支链氨基酸转移氨基的化合物。 这种围手术期血糖升高抑制剂作为对人体生物有安全的药物有用，抑制由麻醉，手术等引起的血糖水平的异常升高，能够适当地控制血糖 围手术期患者。