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公开(公告)号：US07700571B2
公开(公告)日：2010-04-20
申请号：US10455470
申请日：2003-06-05
CPC分类号： A61K38/1866 , A61K48/00 , C12N2799/022
摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.
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公开(公告)号：US07709455B2
公开(公告)日：2010-05-04
申请号：US11535049
申请日：2006-09-25
CPC分类号： A61K38/1866 , A61K48/00 , C12N2799/022
摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.
摘要翻译： 本发明提供了用于肝脏增殖和保护的药物组合物和方法。 特别有用的是能够促进肝脏生长的VEGFR调节剂。 所公开的组合物和方法可用于促进增殖或治疗具有显着生物功能的其它器官中的病理状况。
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公开(公告)号：US20070122394A1
公开(公告)日：2007-05-31
申请号：US11535049
申请日：2006-09-25
CPC分类号： A61K38/1866 , A61K48/00 , C12N2799/022
摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.
摘要翻译： 本发明提供了用于肝脏增殖和保护的药物组合物和方法。 特别有用的是能够促进肝脏生长的VEGFR调节剂。 所公开的组合物和方法可用于促进增殖或治疗具有显着生物功能的其它器官中的病理状况。
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公开(公告)号：US20070244063A1
公开(公告)日：2007-10-18
申请号：US11536880
申请日：2006-09-29
IPC分类号： A61K31/711 , A61K31/00 , A61P15/00 , C12N5/08 , C12Q1/18 , C12N5/06 , A61K31/7105
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
摘要翻译： 本发明提供使用Bv8多肽诱导内皮细胞增殖并增强内皮细胞存活的方法。 本文还提供筛选Bv8活性调节剂的方法。 此外，提供了使用Bv8多肽的治疗方法。
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公开(公告)号：US07811984B2
公开(公告)日：2010-10-12
申请号：US11536880
申请日：2006-09-29
IPC分类号： A61K38/00
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
摘要翻译： 本发明提供使用Bv8多肽诱导内皮细胞增殖并增强内皮细胞存活的方法。 本文还提供筛选Bv8活性调节剂的方法。 此外，提供了使用Bv8多肽的治疗方法。
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公开(公告)号：US07060278B2
公开(公告)日：2006-06-13
申请号：US10231411
申请日：2002-08-27
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
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公开(公告)号：US20060204510A1
公开(公告)日：2006-09-14
申请号：US11384222
申请日：2006-03-17
IPC分类号： A61K39/00
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
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公开(公告)号：US20110151468A1
公开(公告)日：2011-06-23
申请号：US12950824
申请日：2010-11-19
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.
摘要翻译： 本文公开了可用于鉴定可能为癌症患者赋予最佳临床益处的疗法的方法和组合物。
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公开(公告)号：US20090123930A1
公开(公告)日：2009-05-14
申请号：US12265143
申请日：2008-11-05
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.
摘要翻译： 本文公开了可用于鉴定可能为癌症患者赋予最佳临床益处的疗法的方法和组合物。
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