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公开(公告)号：US20100316652A1
公开(公告)日：2010-12-16
申请号：US12861741
申请日：2010-08-23
申请人： Napoleone Ferrara , Kyung Jin Kim
发明人： Napoleone Ferrara , Kyung Jin Kim
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： C07K16/22 , A61K38/179 , A61K38/1866 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, and other diseases and disorders characterized by undesirable or excessive neovascularization.
摘要翻译： 本发明提供了人类血管内皮细胞生长因子（hVEGF）拮抗剂，包括可用于治疗年龄相关性黄斑变性的单克隆抗体，hVEGF受体和hVEGF变体以及以不良或过度新生血管形成为特征的其它疾病和病症。
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公开(公告)号：US07727536B2
公开(公告)日：2010-06-01
申请号：US11537382
申请日：2006-09-29
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US07700571B2
公开(公告)日：2010-04-20
申请号：US10455470
申请日：2003-06-05
CPC分类号： A61K38/1866 , A61K48/00 , C12N2799/022
摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.
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公开(公告)号：US20100092492A1
公开(公告)日：2010-04-15
申请号：US12636593
申请日：2009-12-11
申请人： Napoleone Ferrara , Kyung Jin Kim
发明人： Napoleone Ferrara , Kyung Jin Kim
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/22 , A61K38/00 , A61K47/6425 , A61K47/6811 , A61K47/6843 , A61K2039/505 , C07K14/52 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that inhibit the mitogenic, angiogenic, or other biological activity of hVEGF. The antagonists thus are useful for the treatment of diseases and disorders characterized by undesirable or excessive endothelial cell proliferation or neovascularization. The monoclonal antibodies and receptors of the invention also are useful in diagnostic and analytical methods for determining the presence of hVEGF in a test sample.
摘要翻译： 本发明提供血管内皮细胞生长因子（hVEGF）拮抗剂，包括抑制hVEGF的促有丝分裂，血管生成或其他生物学活性的单克隆抗体，hVEGF受体和hVEGF变体。 因此，拮抗剂可用于治疗以不良或过量的内皮细胞增殖或新生血管形成为特征的疾病和病症。 本发明的单克隆抗体和受体也可用于确定测试样品中hVEGF的存在的诊断和分析方法。
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5.发明授权公开(公告)号：US07470771B2
公开(公告)日：2008-12-30
申请号：US10677471
申请日：2003-10-02
申请人： Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kijavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
发明人： Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kijavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
IPC分类号： C07K14/435 , C07K14/52
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07355002B2
公开(公告)日：2008-04-08
申请号：US10771187
申请日：2004-02-02
CPC分类号： C07K14/47 , C07K14/705 , C07K16/18
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07307152B2
公开(公告)日：2007-12-11
申请号：US10970823
申请日：2004-10-20
申请人： Luc Desnoyers , Napoleone Ferrara , Ellen Filvaroff , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , William I. Wood
发明人： Luc Desnoyers , Napoleone Ferrara , Ellen Filvaroff , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , William I. Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070253959A1
公开(公告)日：2007-11-01
申请号：US11766051
申请日：2007-06-20
申请人： Napoleone Ferrara , Kyung Kim
发明人： Napoleone Ferrara , Kyung Kim
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K38/179 , A61K38/1866 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, and other diseases and disorders characterized by undesirable or excessive neovascularization.
摘要翻译： 本发明提供了人类血管内皮细胞生长因子（hVEGF）拮抗剂，包括可用于治疗年龄相关性黄斑变性的单克隆抗体，hVEGF受体和hVEGF变体以及以不良或过度新生血管形成为特征的其它疾病和病症。
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公开(公告)号：US20070250941A1
公开(公告)日：2007-10-25
申请号：US11691469
申请日：2007-03-26
IPC分类号： A01K67/027 , C12N5/06 , C07K14/71
CPC分类号： C07K14/71 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509 , C12N2800/30 , C12N2830/008
摘要： Transgenic non-human animals and methods of producing non-human transgenic animals comprising within their genome a conditional targeted mutation in a VEGFR, e.g., VEGFR1 or VEGFR2, gene are provided along with methods and vectors used to produce such animals or cells.
摘要翻译： 提供转基因非人动物以及在其基因组中包含VEGFR1（VEGFR1或VEGFR2）基因中的条件靶向突变的非人转基因动物的生产方法以及用于产生这种动物或细胞的方法和载体。
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公开(公告)号：US20070244063A1
公开(公告)日：2007-10-18
申请号：US11536880
申请日：2006-09-29
IPC分类号： A61K31/711 , A61K31/00 , A61P15/00 , C12N5/08 , C12Q1/18 , C12N5/06 , A61K31/7105
CPC分类号： G01N33/5064 , A61K38/00 , C07K14/475 , G01N2500/00
摘要： The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.
摘要翻译： 本发明提供使用Bv8多肽诱导内皮细胞增殖并增强内皮细胞存活的方法。 本文还提供筛选Bv8活性调节剂的方法。 此外，提供了使用Bv8多肽的治疗方法。
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