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1.发明申请公开(公告)号：US20110124869A1
公开(公告)日：2011-05-26
申请号：US12909750
申请日：2010-10-21
申请人： Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
发明人： Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
IPC分类号： C07D487/08 , C07D215/56
CPC分类号： C07D487/08 , C07D215/56
摘要： The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及制备固体形式的N-（4-（7-氮杂双环[2.2.1]庚-7-基）-2-（三氟甲基）苯基）-4-氧代-5-（三氟甲基） -1,4-二氢喹啉-3-甲酰胺，包括化合物1形式A，化合物1形式A-HCl，化合物1形式B和化合物1形式B-HCl，这些形式的任何组合，其药物组合物和方法 治疗。
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2.发明授权公开(公告)号：US08344147B2
公开(公告)日：2013-01-01
申请号：US12909750
申请日：2010-10-21
申请人： Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
发明人： Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
IPC分类号： C07D487/08 , C07D215/56
CPC分类号： C07D487/08 , C07D215/56
摘要： The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及制备固体形式的N-（4-（7-氮杂双环[2.2.1]庚-7-基）-2-（三氟甲基）苯基）-4-氧代-5-（三氟甲基） -1,4-二氢喹啉-3-甲酰胺，包括化合物1形式A，化合物1形式A-HCl，化合物1形式B和化合物1形式B-HCl，这些形式的任何组合，其药物组合物，和 治疗。
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![SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE](/abs-image/US/2012/06/28/US20120165372A1/abs.jpg.150x150.jpg)
3.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式公开(公告)号：US20120165372A1
公开(公告)日：2012-06-28
申请号：US13413327
申请日：2012-03-06
申请人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号： A61K31/47 , A61P11/00 , A61P7/04 , A61P3/06 , A61P7/00 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/14 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/14 , A61P27/04 , A61P17/00 , C07D215/56
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译： 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。
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4.发明申请公开(公告)号：US20100234606A1
公开(公告)日：2010-09-16
申请号：US12704903
申请日：2010-02-12
申请人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号： C07D213/36 , C07D213/78
CPC分类号： C07D213/80 , C07D213/803
摘要： The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译： 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。
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5.发明授权公开(公告)号：US08461345B2
公开(公告)日：2013-06-11
申请号：US13591380
申请日：2012-08-22
申请人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号： C07D213/82 , C07D213/803
CPC分类号： C07D213/80 , C07D213/803
摘要： The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译： 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。
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6.发明申请公开(公告)号：US20120316345A1
公开(公告)日：2012-12-13
申请号：US13591380
申请日：2012-08-22
申请人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
发明人： Stefanie Roeper , Adam R. Looker , Theodore A. Martinot , Bobbianna Neubert-Langille , Michael P. Ryan , John R. Snoonian
IPC分类号： C07D213/82 , C07D213/803
CPC分类号： C07D213/80 , C07D213/803
摘要： The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
摘要翻译： 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。
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![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2012/04/24/US08163772B2/abs.jpg.150x150.jpg)
7.发明授权Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号：US08163772B2
公开(公告)日：2012-04-24
申请号：US12283702
申请日：2008-09-15
申请人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译： 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。
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8.发明申请PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR制造调制器的工艺公开(公告)号：US20100267768A1
公开(公告)日：2010-10-21
申请号：US12728173
申请日：2010-03-19
申请人： John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
发明人： John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D.J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
IPC分类号： A61K31/47 , C07D215/233 , C07C69/96 , C07D307/77 , A61P11/06 , A61P1/18 , A61P15/10 , A61P37/08 , A61P1/16 , A61P3/00 , A61P25/28 , A61P3/10 , A61P37/00 , A61P7/12 , C12N5/07 , C12Q1/02
CPC分类号： C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
摘要： The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
摘要翻译： 本发明提供了制备式1化合物的方法，包括在偶联剂存在下将式2的羧酸与式3的苯胺偶联。
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![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2009/04/16/US20090099230A1/abs.jpg.150x150.jpg)
9.发明申请Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号：US20090099230A1
公开(公告)日：2009-04-16
申请号：US12283702
申请日：2008-09-15
申请人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人： John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译： 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。
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![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2013/01/29/US08362253B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US08362253B2
公开(公告)日：2013-01-29
申请号：US13413327
申请日：2012-03-06
申请人： John DeMattei , Yushi Feng , Cristian L. Harrison , Adam R. Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人： John DeMattei , Yushi Feng , Cristian L. Harrison , Adam R. Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
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