公开(公告)号：US20110251679A1

公开(公告)日：2011-10-13

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US08491650B2

公开(公告)日：2013-07-23

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US08876892B2

公开(公告)日：2014-11-04

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US20110264200A1

公开(公告)日：2011-10-27

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US08771344B2

公开(公告)日：2014-07-08

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20140005769A1

公开(公告)日：2014-01-02

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US08512400B2

公开(公告)日：2013-08-20

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20110251680A1

公开(公告)日：2011-10-13

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US08740976B2

公开(公告)日：2014-06-03

申请号：US13091938

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer

发明人： Don Tran ,  Nathan Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached includes a shaft assembly including a distal portion and an intermediate portion, and an inner lumen extending through the shaft assembly. The delivery system includes a sheath assembly defining an outer lumen sized to slidably receive the shaft assembly. At least one flush port is formed in the intermediate portion. The at least one flush port is in fluid communication with the inner lumen and the outer lumen. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve.

摘要翻译： 用于具有附接有阀结构的支架框架的假体心脏瓣膜的输送系统包括：轴组件，其包括远端部分和中间部分;以及内腔，其延伸穿过所述轴组件。 输送系统包括护套组件，其限定尺寸适于可滑动地容纳轴组件的外腔。 在中间部分形成至少一个冲洗口。 至少一个冲洗口与内腔和外腔流体连通。 输送系统被配置成从其中护套组件包围假体心脏瓣膜的负载状态转变到其中护套组件从假体心脏瓣膜抽出的展开状态。

公开(公告)号：US20110264199A1

公开(公告)日：2011-10-27

申请号：US13091938

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer

发明人： Don Tran ,  Nathan Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached includes a shaft assembly including a distal portion and an intermediate portion, and an inner lumen extending through the shaft assembly. The delivery system includes a sheath assembly defining an outer lumen sized to slidably receive the shaft assembly. At least one flush port is formed in the intermediate portion. The at least one flush port is in fluid communication with the inner lumen and the outer lumen. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve.

摘要翻译： 用于具有附接有阀结构的支架框架的假体心脏瓣膜的输送系统包括：轴组件，其包括远端部分和中间部分;以及内腔，其延伸穿过所述轴组件。 输送系统包括护套组件，其限定尺寸适于可滑动地容纳轴组件的外腔。 在中间部分形成至少一个冲洗口。 至少一个冲洗口与内腔和外腔流体连通。 输送系统被配置成从其中护套组件包围假体心脏瓣膜的负载状态转变到其中护套组件从假体心脏瓣膜抽出的展开状态。