公开(公告)号：US11819570B2

公开(公告)日：2023-11-21

申请号：US17055032

申请日：2019-05-31

申请人： National University Corporation Tokai National Higher Education and Research System ,  National University Corporation Tokyo Medical and Dental University

发明人： Takayoshi Suganami ,  Miyako Tanaka ,  Akira Matsumoto ,  Hiroko Matsumoto ,  Yuki Morooka ,  Yuji Miyahara

IPC分类号： A61K9/06 ,  A61K38/28 ,  A61K47/32 ,  A61M37/00

CPC分类号： A61K9/06 ,  A61K38/28 ,  A61K47/32 ,  A61M37/0015 ,  A61M2037/0023

摘要： A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.

公开(公告)号：US11141486B2

公开(公告)日：2021-10-12

申请号：US15770125

申请日：2016-10-24

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Akira Matsumoto ,  Hiroko Matsumoto ,  Takayoshi Suganami ,  Miyako Tanaka ,  Yuji Miyahara

IPC分类号： A61K47/32 ,  A61K38/28 ,  A61M5/32 ,  A61M5/142 ,  A61K9/00 ,  A61K9/70 ,  A61M25/00 ,  A61M37/00 ,  C08F220/56 ,  A61K47/16

摘要： An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

公开(公告)号：US20200166506A1

公开(公告)日：2020-05-28

申请号：US16608609

申请日：2018-04-25

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Yuji Miyahara ,  Akira Matsumoto ,  Tatsuro Goda ,  Yukichi Horiguchi

IPC分类号： G01N33/543 ,  G01N27/12 ,  G01N1/38 ,  G01N33/569 ,  G01N33/553

摘要： A modified nanoparticle includes a nanoparticle, a dispersibility improving group bound to a surface of the nanoparticle, and an oligosaccharide that is bound to the surface of the nanoparticle, and that selectively captures a specific virus or bacterium. A reagent for detection of a specific virus or bacterium by resistive pulse sensing is also provided, the reagent including the modified nanoparticle.